Mystery peptide with high endotoxin results

[Habibibi]

Looks like we may have a new endotoxin level winner, at over 1000 EU/vial. Estimate provided is probably low

[Imported image pending local asset: attachments-1773938269884-webp.17931]

This is all that was posted, testing group is choosing to keep vendor hidden, for now.

 

[Mr.Tired]

Yikes. Hope they opt to release the name, that's alarming.

 

[Calm Logic]

testing group is choosing to keep vendor hidden, for now.

Bastards.

 

[tendency]

Gemini is telling me that standard filtering will not remove endotoxins?

 

[Habibibi]

Gemini is telling me that standard filtering will not remove endotoxins?

Correct

 

[Calm Logic]

How many in the group are going to trash it?

 

[Chili777]

How many in the group are going to trash it?

I would. Vendors don't typically refund or reship based on endontoxins, AFAIK. I've seen a few NAD+ samples test >100 EU/vial lately, but nothing over 1000. I saw Peter M discussing this today, but it was a private test and the vendor and peptide wasn't mentioned.

 

[Habibibi]

If anyone has this batch, and wants to get rid of it, contact me, I'm willing to buy it for testing experiments.

 

[Calm Logic]

I've seen a few NAD+ samples test >100 EU/vial lately, but nothing over 1000.

Yeah, I see Uther's NAD 500 mg was 984 EU/vial in a 3P test.

 

[Chili777]

Gemini is telling me that standard filtering will not remove endotoxins?

You need special charged filters for endotoxin. They run about $20 each. Most endos are handled by your natural defenses, and there is a calculation to determine what your body can handle based on time (like how often it's exposed) and weight. It's not usually a problem unless you have an immune condition, or until we get up into some of the values we're starting to see recently. I never used to worry about it, but I'm glad people are testing for it more often.

 

[Calm Logic]

You need special charged filters for endotoxin. They run about $20 each.

Does someone sell them individually? Normally, you have to buy 10, it seems.

$288.30 for a pack of 10:

https://www.vwr.com/us/en/product/7605181/acrodisc-units-with-mustang-e-membrane-cytiva-formerly-pall-lab?r=1

But, ideally, you want 10 for a whole kit (though you could filter multiple vials at once, I suppose). So cheaper to just throw the trash away.

 

[tendency]

Yeah, I see Uther's NAD 500 mg was 984 EU/vial in a 3P test.

Shoot, I just ran a bunch of Uther NAD+ .. no issues.

You need special charged filters for endotoxin. They run about $20 each. Most endos are handled by your natural defenses, and there is a calculation to determine what your body can handle based on time (like of often it's exposed) and weight. It's not usually a problem unless you have an immune condition, or until we get up into some of the values we're starting to see recently. I never used to worry about it, but I'm glad people are testing for it more often.

Ok that's good to hear I was wondering how concerned I should be about all this. Thanks for the charged filter idea, I haven't heard of people doing that in practice?

 

[Calm Logic]

I haven't heard of people doing that in practice?

Probably due to cost. The charged endo filter can cost more than a vial of the peptide.

 

[Chili777]

Does someone sell them individually? Normally, you have to buy 10, it seems.

$288.30 for a pack of 10:

https://www.vwr.com/us/en/product/7605181/acrodisc-units-with-mustang-e-membrane-cytiva-formerly-pall-lab?r=1

But, ideally, you want 10 for a whole kit (though you could filter multiple vials at once, I suppose). So cheaper to just throw the trash away.

Yes, for a kit. I did see them individually last year, but at $20 each, I decided I'd take my chances. Not surprised they're more now.

 

[vewdew34]

Looks like we may have a new endotoxin level winner, at over 1000 EU/vial. Estimate provided is probably low

View attachment 17931

This is all that was posted, testing group is choosing to keep vendor hidden, for now.

Well that testing group should name the vendor so people don't buy that junk.

 

[Habibibi]

Probably due to cost. The charged endo filter can cost more than a vial of the peptide.

GLP1s are negatively charged. These are positively charged filters. They will filter out endotoxins along with the peptide with them.

 

[Calm Logic]

So the mystery peptide is a GLP! Haha.

 

[littledragon25]

Looks like we may have a new endotoxin level winner, at over 1000 EU/vial. Estimate provided is probably low

View attachment 17931

This is all that was posted, testing group is choosing to keep vendor hidden, for now.

Let's not spread lies.

We have not ‘decided to keep it private’.

It is one result of a few tests on the same pep and we haven’t had the other results yet. The people who paid for the test haven’t had the full picture and so it isn’t ready for release yet. This result has been with us for less than 48 hours and we are doing due diligence to check it before releasing. That is the responsible thing to do. We also issued a warning to put a hold on using this batch (including naming the vendor) until we could verify results.

The test lead himself posted it in STG to ask Peter M to clarify as it is an estimate, which is a change to Endotoxin testing as this appears to now need to be tested at different dilutions for accurate results not estimates. We do not know how accurate the result is as Peter himself has said it needs to be tested at the right dilution.

We have 2 other vials on the way to verify the result at different dilutions.

We aren’t in the business of releasing unverified results and causing mass panic.

 

[oldrunnerguy]

On a Telegram forum for one of the vendors who are on this forum, I was ridiculed for sending out my peptides for endotoxins testing. "What a waste of money" I was told. Well, it was worth it to me.

 

[Chili777]

On a Telegram forum for one of the vendors who are on this forum, I was ridiculed for sending out my peptides for endotoxins testing. "What a waste of money" I was told. Well, it was worth it to me.

It's good information, but the question is what do you do with that information. If you have a vial test for <100 EU, you can still use it. If it's >100 EU, that's higher, but your vendor won't reship or refund based on endotoxin testing. So, if then it becomes: how often will I be using this >100 EU peptide (exposure)? If it's daily, you'd probably be fine. Multiple time a day, you would need to do the calculation. Weekly use, you definitely would be OK. Now with the test above of >1000 EU in one vial, that's over the top and Peter M. says it's the highest EU he's ever recorded. I haven't seen if the test was verified, but that kit is a toss and the question becomes: how much else is out there for this vendor and what is it?