Manufacturing methods research

[brentm]

I think the only person who would have the best chance to most accurately track the source of a peptide is Jano due to the sheer volume of testing they do.

They don't test for TFA or HCI. Only for the peptide itself. I'm not certain they can, or have the ability, to test for TFA.

I was under the impression that nearly all peptides start out with TFA as it is required to cleave the peptides off the solid-phase resin. But maybe they can use HCI for the same process.

I've heard the acetate form is the most desirable, but results in lower purity than other forms. So if you're seeing 99 percent purity, likely not acetate form.

The question I want to know and get a better handle on, is how much TFA is actually present in each dose and does it pose any short or long-term health risks? USP limit is 0.05 percent TFA presence.

Very little data exists on this. You can find studies based on inhaled anesthetics that convert to TFA in the body and cause liver damage. But I'd swagger that TFA amounts in this case are significantly greater than what we might be exposed to.

Best I can do is "anecdotal" evidence that the TFAs present don't cause any short-term health risks. And Janoshik is quoted as saying TFAs presence in these meds is "absolutely inconsequential" when speaking to in vitro use of these peps.

 

[Bacchus]

Just to add some info that might have been missed.

Initially I heard the "handful of labs" argument. Along with the "compounding pharmacies purchase from the same channels as gray market"

I believe both of those statements are false. Or more likely false in most cases.

I've heard from someone that I consider to be an expert that there are hundreds of labs.

The "everything is from the same source" argument is definitely a bit silly.

It doesn't make sense - And even if it was true, there is a significant difference in how a registered compounding pharmacy handles the raws they buy, compared to a licensed lab making some dough on the side, compared to a proper ug lab, compared to a Walter white RV.

As for "a handful" that is a very loosely defined term, "a handful out of the amount of labs and "labs" offering these products, actually manufacture the raws themselves", would be more accurate I suppose.

As for the salts, my personal take is that it's a nothing burger - But it sure seems scary since it's difficult to have a full understanding of the significance. It's rather similar to the discussion about sterility - the more tests are done, the more failed tests we'll see.

I wouldn't really be surprised if compounding pharmacies failed sterility tests too if people started doing 3rd party tests (This is not something I know, just an assumption - re-sterilizing raws can be quite expensive)

 

[mostlydamp]

I'm assuming that production of these compounds could be linked pretty heavily to organized crime in China, right? I mean I could be wrong, but I understand that even above the board businesses may deal with corruption in China. These are businesses that have to either truly stay hidden or "stay hidden" with CCP bribes. When I bought from QSC I took a look at just the crypto wallet that I transferred to and it had I think 5-6 million dollars worth of crypto that had been transferred to it. I had an "...oh" moment when I realized that this is organized crime on a relatively large scale. That would come with a lot of protection for the organization and a lot of fear when it comes to revealing details of any kind.

 

[Bacchus]

I'm assuming that production of these compounds could be linked pretty heavily to organized crime in China, right? I mean I could be wrong, but I understand that even above the board businesses may deal with corruption in China. These are businesses that have to either truly stay hidden or "stay hidden" with CCP bribes. When I bought from QSC I took a look at just the crypto wallet that I transferred to and it had I think 5-6 million dollars worth of crypto that had been transferred to it. I had an "...oh" moment when I realized that this is organized crime on a relatively large scale. That would come with a lot of protection for the organization and a lot of fear when it comes to revealing details of any kind.

You are not wrong