Liraglutide from Grey

[Calm Logic]

One of them I just found isn't even a medication but ultrasound therapy for "stimulating nerve pathways to produce effects such as increased glucose metabolism":

Beyond GLP-1: the next wave of weight-loss medication innovation

“There is a real sense now of a rapid expansion in the area of novel medications in the area of obesity,” says Hannah Beba, pharmacist and clinical lead for obesity at West Yorkshire Integrated Care System. Amira Guirguis, pharmacy professor and chair of the Science and Research Committee of...

pharmaceutical-journal.com

Perhaps Novo Nordisk’s most novel offering is a once-monthly ultrasound treatment for obesity, currently in early stages of exploration as part of a collaboration with GE Healthcare.

Announcing the collaboration in 2023, GE HealthCare said peripheral focused ultrasound therapy — which uses ultrasound to activate the nervous system, stimulating nerve pathways to produce effects such as increased glucose metabolism — has potential as a non-invasive, non-pharmacological alternative for chronic disease management.

 

[Labcat]

One of them I just found isn't even a medication but ultrasound therapy for "stimulating nerve pathways to produce effects such as increased glucose metabolism":

I hope that will be supersonically slapping my arm around rather than my liver!

 

[MsGizmo]

Is it possible to get liraglutide from grey vendors. I know its not nearly as effective from a results standpoint, but just curious.

I've seen it in the past but you won't see it often as its not very popular. While it was an ok drug for its time, semaglutide is so much more effective and its a weekly shot instead of a daily one.

My husband took the name brand for his diabetes for a few years before switching to name brand ozempic. Just yesterday he made the jump to grey market tirzepitide. Each switch has resulted in better blood sugar control for him, but I worry about him losing weight since he is already thin (BMI 18.9) If he loses more weight he will cross over into the underweight category.

 

[Calm Logic]

The only hesitation I might have about orforglipron is that although it accomplishes the same thing as GLP-1RA peptides, it is fundamentally different in that it's a drug designed to accomplish the same effect. Novo's pill is just a novel delivery mechanism to get a peptide from the stomach to the gut, so theoretically should have a similar risk profile to semaglutide. You can't really say the same thing about orforglipron. Although, I guess one could level the same critique about the newest peptides that add glucagon agonism too.

I thought orfo would be "the answer" for some grey newbies to get started. But lower-dose tablets like 3 mg are not available at all. The Chinese usually know what the market wants, so I guess they knew orfo would be more for traveling GLP veterans or for end-stage maintainers.

On the positive side with lira pens, it is hard to overdose that way since you need two shots (1.2 mg and 1.8 mg) to get the max dose for obesity (3 mg).

 

[indolent]

@druell235, this reply is a couple of weeks late, but: the handy compound-finder feature on Data Mining Site Official identifies two grey vendors currently offering liraglutide. The first has been used recently by a reputable group buy. I've never heard of the second.

I would make no recommendation for or against either, though.