两周过去了，没有看到任何进展。

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amosmylove

amosmylove

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大家好。我服用GLP-1受体激动剂的时间不长。我服用灰色包装的Tirz已经9周了。昨天刚服用了第二剂，剂量为7.5毫克。9周前我开始服用，剂量为2.5毫克。前7周我减掉了19磅（约8.6公斤），副作用也还可以忍受，主要是打嗝和腹泻，算是比较严重的副作用。然而，

大约两周以来，我的体重没有变化，甚至没有减轻。我原以为剂量增加到7.5毫克后，体重就会开始明显变化。我还注意到，过去两周我更容易感到饥饿，饱腹感也降低了。

最可能的原因是，当我增加剂量到7.5毫克时，我也开始服用一瓶新的60毫克装的Tirz。虽然两瓶药都是从同一个网站购买的，但我第一瓶是30毫克装的。我怀疑60毫克的药瓶效力是不是比较弱，或者第一瓶的内毒素含量更高，导致我肠胃不适？用了这瓶新的之后，我没有出现任何胃部不适、打嗝或腹泻的情况。

我想知道，如果你是我，你会怎么做？增加剂量，还是在周中服用一次试试看能不能见效？

我之前每周稳定减重2.5磅左右，但现在已经超过两周没有变化了。我的饮食绝对没有不健康或过量。我仍然保持热量摄入不足，而且大部分时间都在禁食。我最近有点懒散，感觉精力不足，这可能是之前几个月体重下降造成的。

初始体重207磅，目前189磅。

上周我刚结束了一个BPC/TB组合疗程，还有一个DSIP疗程。

这种情况没有变化正常吗？还是说我买到的这瓶药有问题？
 
服用Tirz后，通常需要4周，有时甚至5到6周才能完全感受到效果。在增加剂量或评估其疗效之前，至少应该等待这么长时间。您应该使用最低有效剂量，这样如果开始产生耐药性，您还有增加剂量的空间。等待4周后再增加剂量也有助于预防或减少副作用。

体重减轻相当一部分后，出现几周的平台期也是正常的。您的身体需要重新调整。我建议您 至少

再服用7.5毫克 两周。
 
Chances of a “bad vial” are pretty low. It is recommended to stay on each dose a minimum of four weeks, and it’s also not considered a stall or plateau unless you have not lost for 4 weeks. 19lbs in 7 weeks is very quick loss, and your body is likely just adjusting. Stay at 7.5 for at least the next two weeks, if you see no movement on the scale at that point, then I would think about titrating up
 
cheaperseeker said:
It takes 4 weeks, sometimes 5 or 6, to start feeling the full effects of tirz. You should wait at least that long before increasing to a higher dose or assessing whether it's working or not. You want to be on the lowest effective dose so that you have room to increase if you start building a tolerance. Waiting 4 weeks before increasing helps to prevent or decrease side effects as well.

It's also normal for your weight to plateau for a few weeks after losing a fair amount. Your body just has to recalibrate.

I'd continue at 7.5mg for at least 2 more weeks.
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I felt confident that I was responding really well to it almost immediately. It's just that since starting a different vial everything is different. Almost like I'm at half the old dose.

When you say it takes 4 weeks, or 5 or 6, to feel the ' full effects of tirz' are you meaning 4-6 weeks at a specific dosage? Why do clinical guidelines suggest titrating up every 4 weeks if it should take longer? Maybe I am just misunderstanding you though.

I just don't understand why I was responding so well to the 2.5/5mg dosages and now going to 7.5 it plateaus . Seems counterintuitive. Unless the vial is less potent/junk. That's when things changed.
 
One more thing. Fasting for most of the day is likely contributing to your lack of energy.

Are you a woman? I recently heard that all the studies that say fasting is so good for you were done on men, and it likely is not so great for women because our bodies are more sensitive to energy availability. So, if your body is sensing food scarcity, it could be holding onto the weight to have "back-up energy".

Even if you're a man, too much of a calorie deficit could signal scarcity.

Eat at least 3 times throughout the day and make sure you're getting enough calories. I'd actually recommend not tracking calories at all and just eating when you're hungry. You might be surprised by what the scale tells you when you relax and let the tirz do it's job.
 
wileyhorse said:
Chances of a “bad vial” are pretty low. It is recommended to stay on each dose a minimum of four weeks, and it’s also not considered a stall or plateau unless you have not lost for 4 weeks.
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I can hang out at 7.5. I guess the lack of any side effects while also increasing the dose is making me think it's not working. I don't enjoy diarrhea, but I knew the glp1 was doing it's thing when I had it! LOL

I need to be more patient. I have been expecting to keep loosing consistently so I was disconcerted at no change for 2 weeks and counting.
 
amosmylove said:
I felt confident that I was responding really well to it almost immediately. It's just that since starting a different vial everything is different. Almost like I'm at half the old dose.

When you say it takes 4 weeks, or 5 or 6, to feel the ' full effects of tirz' are you meaning 4-6 weeks at a specific dosage? Why do clinical guidelines suggest titrating up every 4 weeks if it should take longer? Maybe I am just misunderstanding you though.

I just don't understand why I was responding so well to the 2.5/5mg dosages and now going to 7.5 it plateaus . Seems counterintuitive. Unless the vial is less potent/junk. That's when things changed.
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Because plateaus are a thing. It’s not the medicine or the dose. It’s your body taking a reset.

Also, are you meeting your protein goals? That can affect loss rates.

Additionally- are you getting your kits tested/joining a group test? Vendor test results can’t be trusted. I doubt the kit is junk, but without testing there is no way to know.
 
cheaperseeker said:
One more thing. Fasting for most of the day is likely contributing to your lack of energy.

Are you a woman? I recently heard that all the studies that say fasting is so good for you were done on men, and it likely is not so great for women because our bodies are more sensitive to energy availability. So, if your body is sensing food scarcity, it could be holding onto the weight to have "back-up energy".

Even if you're a man, too much of a calorie deficit could signal scarcity.

Eat at least 3 times throughout the day and make sure you're getting enough calories. I'd actually recommend not tracking calories at all and just eating when you're hungry. You might be surprised by what the scale tells you when you relax and let the tirz do it's job.
Click to expand...
I am a woman, yes. I don't track anything but I do know I am at a deficit simply from years past of monitoring my food intake and scale response. I maintain my weight at about 1800-2000k and lose if under 1500 cals. I am definitely under that 1500 mark these days.

I have not been earing 3x a day in general. Usually my first meal is at dinner and a snack before bed. Sometimes a snack in the late morning.

I've been eating mainly salmon or chicken everyday.

I'll have to been more deliberate about eating more often to not be overtired.
 
amosmylove said:
I am a woman, yes. I don't track anything but I do know I am at a deficit simply from years past of monitoring my food intake and scale response. I maintain my weight at about 1800-2000k and lose if under 1500 cals. I am definitely under that 1500 mark these days.

I have not been earing 3x a day in general. Usually my first meal is at dinner and a snack before bed. Sometimes a snack in the late morning.

I've been eating mainly salmon or chicken everyday.

I'll have to been more deliberate about eating more often to not be overtired.
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Ah. Are you eating enough? You really need to track your intake. There are free trackers like my fitness pal that can let you track your calories, protein, et cetera. Getting enough protein not only will help with fatigue , it will prevent the hair loss that many experience during weight loss
 
amosmylove said:
I felt confident that I was responding really well to it almost immediately. It's just that since starting a different vial everything is different. Almost like I'm at half the old dose.

When you say it takes 4 weeks, or 5 or 6, to feel the ' full effects of tirz' are you meaning 4-6 weeks at a specific dosage? Why do clinical guidelines suggest titrating up every 4 weeks if it should take longer? Maybe I am just misunderstanding you though.

I just don't understand why I was responding so well to the 2.5/5mg dosages and now going to 7.5 it plateaus . Seems counterintuitive. Unless the vial is less potent/junk. That's when things changed.
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Yes, 4-6 weeks at each dose.

It could just be coincidence that your stall happened when you started a new vial. Although, as wileyhorse said, it's not really considered a stall until you've been at the same weight for at least 4 weeks, because it's normal for weight loss to pause occasionally. You also lost that weight pretty fast. A "healthy" amount to lose is 0.5 - 2 pounds per week. Still, it wouldn't hurt to recheck your reconstitution and dosing math as well.

The guidelines probably say 4 weeks because most people's levels are close to the full amount by that time, and they wanted to have a standard protocol that they could give everyone so they don't have to do blood work on each patient every week. But everyone is a little different. I've noticed it takes me around 5 weeks to feel the effects fully and consistently.

It's good that you're getting in protein, but make sure you are getting some healthy carbs and fats, too.
 
Every time someone says they're not losing weight, a bunch of people show up to tell them they need to be eating more. More meals, more carbs, more everything. Makes absolutely no damn sense.

I don't mean to be abrasive but like, that's just not know anything works. Try eating more salad, more soup, more vegetables, more exercise, and fewer calories. It's ok to skip meals, it will not kill you. You don't have to if you don't want to, but for a healthy overweight adult it's not gonna cause any harm. Forcing yourself to eat three meals a day when you don't feel like it just defies all logic.
 
deleted.user.16 said:
Every time someone says they're not losing weight, a bunch of people show up to tell them they need to be eating more. More meals, more carbs, more everything. Makes absolutely no damn sense.

I don't mean to be abrasive but like, that's just not know anything works. Try eating more salad, soup, vegetables and fewer calories. It's ok to skip meals, it will not kill you. You don't have to if you don't want to, but for a healthy overweight adult it's not gonna cause any harm. Forcing yourself to eat three meals a day when you don't feel like it just defies all logic.
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You absolutely do need to eat a certain amount of calories to lose weight and to stay healthy.

Some key points from the article below (there are also many other articles and studies from credible sources that say the same things):

Extremely low-calorie diets trigger metabolic adaptation, forcing the body to slow its metabolism and conserve energy, which causes a weight-loss plateau. Additionally, this can lead to muscle loss, severe fatigue, increased cravings, and hormonal imbalances, making it harder to sustain long-term weight loss.~

Why Eating Too Little Can Stall Weight Loss

Eating too little doesn’t speed up fat loss but it slows it down. Your metabolism needs energy to function well, and nourishment is the key to sustainable progress. Check out more information in this article.

www.weightkidneycare.com
 
cheaperseeker said:
You absolutely do need to eat a certain amount of calories to lose weight and to stay healthy.

Extremely low-calorie diets trigger metabolic adaptation, forcing the body to slow its metabolism and conserve energy, which causes a weight-loss plateau. Additionally, this can lead to muscle loss, severe fatigue, increased cravings, and hormonal imbalances, making it harder to sustain long-term weight loss.
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I know all about unhealthy weight loss. A few years ago I got hit with some major depression. Lost 40lbs in 3 months. Not on purpose. It was just legit major depression. Then lost almost all of my hair! Which triggered worse depression. That sucked big time as a woman. It's all back now but I started wearing wigs because of it.
 
amosmylove said:
I know all about unhealthy weight loss. A few years ago I got hit with some major depression. Lost 40lbs in 3 months. Not on purpose. It was just legit major depression. Then lost almost all of my hair! Which triggered worse depression. That sucked big time as a woman. It's all back now but I started wearing wigs because of it.
Click to expand...
😟 All of that sucks big time. I hope you were able to work through it, and are feeling better lately.
 
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