Less is More. How do you manage impulsive urges to increase dose or more peps.

[Mr. Blonde]

Also...I just load up and start blasting!

 

[lessthanhalf]

Eating disorder or substance abuse disorder aside, if one were to look at the effect on the mind, it is clear that one of the toughest causes of the resilience of obesity is the lack of hunger control. This cannot exist without ghrelin being involved. Similarly, urges are tied to dopamine. Now, the most likely reason why ghrelin is so uncontrollable in obese people could be because of leptin resistance rather than a mere overproduction of ghrelin.

People are responsible for their choices and actions. That doesn't mean that hormones cannot control the mind. That is undeniable. Hence, awareness of an issue should be followed by deliberate agency and action designed to resolve it. If usage of GLPs is mandated for life because the person cannot control their hunger pangs, apart from a mere loss of willpower and self-control, it is also a definite sign of faulty brain functioning, which could have been caused by prolonged exposure to the offending hormone's unfettered activity.

If leptin resistance is the problem, testing one's satiety is a good bet to see if it is the case for an individual. Potatoes have the highest satiety on the satiety index. If people crave high-calorie foods after potato satiation, then there is leptin resistance involved.

I would look towards using GLp's until our body gets rid of the leptin resistance, and over time, healthy habits should rewire the brain away from unhealthy habits. There's a reason Atomic Habits is among the most read books in the world.

My experience is that the post weight loss metabolic state of increased hunger and reduced energy expenditure, just keeps on going. Without GLP's I lost 70 kg from 145 to 75kg, on a calorie intake of 1600-1900 kcal /day, and with no change in intake, weight loss slowed and stopped at 75kg at the same number of calories, and it has stayed there ever since, for a year without GLP's , a year on low dose ozempic and 10 months on reta/tirz, with a bit of extra weight loss on reta/tirz to 65kg, and all that required the same calorie intake with no sign of any recovery in energy expenditure or reduced appetite, except for the GLP drug effect on hunger, and probably 1-200 kcal/day lower intake on reta/tirz to lose the last 10kg. This is despite a diet with absolutely minimal blood glucose variation, very high protein , no high glycaemic index foods and a hb1ac of 5 to start with and on reta /tirz of 4.5, so there is good evidence of metabolic state improvements, but not in calories per day or hunger.

There is some evidence of long term improvement in energy expenditure over time post weight loss in some studies, but in general weight loss maintenance is very poorly researched, which is a pity as , as far as I am concerned, it is the real problem, and where nearly all weight loss fails, with the exception of staying on glps long term.

 

[birdwhacker]

I have a mental limit of doing a max of 3 things at a time. Currently, Reta, Klow and MOTS-C.

That's six things, Stacy.

Wait until you take too much shit and start feeling off. It sucks.

How did you manage to pull this off with peps? I'm curious.

I've done this MANY times with supplements, from destroying my methylation cycle by megadosing niacin or glycine, mobilizing heavy metals with ALA, causing DAO shutdown with NAC, making myself spaced out with insane doses of Vitamin C and Magnesium... Did it for years.

But, I learned a lot and I'm at a very good place with the supplements now, and the peptides are just falling into place. Currently running reta, BPC and KPV, bronchogen, epitalon daily, about to add in TB4 as well. A few other peps off and on. Trying not to add anything too fast and... It's working. I feel pretty great lol.

So tell me where you went south so I can avoid it!

I’m considering the Tirz - Reta split as well. Thanks

Me three. I don't really want to take 12mg of reta. I'm interested in adding both tirz and cagri down the roadz maybe around 8mg. I'm a firm believer in shotgun polypharmacology. The more receptors you hit, the less likely shit is to go south.

Maxing out the dose on one drug is the pharmacokinetic equivalent of cultivating a single crop – you're practically begging for a plague.

 

[birdwhacker]

I can't put enough sketchy chinese WhoKnowsWhat into my body all day every day. Surprisingly, I feel fantastic, with almost no sides.

Say it louder for the people in the back. Injecting random bullshit has me in the best health of my life.

Trial data can absolutely be misinterpret, please take a look at some resources from Dr. Jones about lowest effective dose and titrating up.

I don't do influencer doctors.

As a therapist who specializes in eating disorders and addiction, I pretty strongly feel that BED is wrongly categorized as an eating disorder. It really belongs in the substance abuse disorder category.

As a long time substance abuser, I'll get 100% behind you. My relationship with food has been, and arguable still is, strictly pharmaceutical. I'm some brand of autistic and drugs became my special interest and trauma cope. I see everything through a chemical lens. When I ordered a milkshake, I would think "drinking all of this sugar is going to make me feel good, if i time it right I might even be able to take a nap." Or "this cheese burger is going to help me blow off some steam after work." Compulsive redosing. Stealing it from friends and family. Manipulating people to get more.

Now, the relationship has changed a little bit and I view food the same way a bodybuilder might view anabolic compounds. I eat the green shit and fruit because I need the fiber and micronutrients. I eat the chicken breasts because they maintain my muscles. I eat the cheese sticks before bed to sustain my insulin release by slowly digesting the casein throughout the night.

There is something deeply wrong with me, but now at least it's pointed away from my face.

 

[lessthanhalf]

How did you manage to pull this off with peps? I'm curious.

It is incredibly easy with GLP peptides, a bit of a dose increase and you feel like garbage, nauseous maybe with vomiting, not much fun.

I don't do influencer doctors.

I could not agree more, possibly the least credible medical source possible, they are almost certainly selling something or selling themselves, which does not tend to produce reliable scientifically credible information.

 

[cloratheshadow]

That's six things, Stacy.

How did you manage to pull this off with peps? I'm curious.

I've done this MANY times with supplements, from destroying my methylation cycle by megadosing niacin or glycine, mobilizing heavy metals with ALA, causing DAO shutdown with NAC, making myself spaced out with insane doses of Vitamin C and Magnesium... Did it for years.

But, I learned a lot and I'm at a very good place with the supplements now, and the peptides are just falling into place. Currently running reta, BPC and KPV, bronchogen, epitalon daily, about to add in TB4 as well. A few other peps off and on. Trying not to add anything too fast and... It's working. I feel pretty great lol.

So tell me where you went south so I can avoid it!

Me three. I don't really want to take 12mg of reta. I'm interested in adding both tirz and cagri down the roadz maybe around 8mg. I'm a firm believer in shotgun polypharmacology. The more receptors you hit, the less likely shit is to go south.

Maxing out the dose on one drug is the pharmacokinetic equivalent of cultivating a single crop – you're practically begging for a plague.

For me it was just stacking too many peps that make me feel altered. Like Cagri makes me tired Reta gives me aches CJC/Ipa gives me head rushes so if I overdo any of them I just feel like trash. But everyone has different tolerances! I seem to be hyper responder to almost everything I take. I also got too obsessed with supplements so I was taking like 12. Just noticed I introduced too many things all at once. It’s better to try to add things slowly so if you do feel weird you know what’s causing it! Now if I add something I only add that one thing until I know for sure it’s tolerated. Plus there are on and off cycles so I remind myself that I can always try the others on my off cycles. It’s hard not to want to try everything. It’s hard also if you really take a lot of supplements on top of it.

How has epithalon been for you? I’ve been wanting to try it myself!

 

[Smiter]

My experience is that the post weight loss metabolic state of increased hunger and reduced energy expenditure, just keeps on going

As mentioned by others earlier, I think that even if the adipose tissue loses all its cytoplasm, the shells remain metabolically active. What do you reckon? Would people who do liposuction AFTER the weight loss- removing what's left, fare better in this regard? I have been doing research on leptin resistance for a long time, albeit secondary. The logical state of this context hits my brain too harshly to ignore.

, and it has stayed there ever since, for a year without GLP's , a year on low dose ozempic and 10 months on reta/tirz, with a bit of extra weight loss on reta/tirz to 65kg, and all that required the same calorie intake with no sign of any recovery in energy expenditure or reduced appetite, except for the GLP drug effect on hunger, and probably 1-200 kcal/day lower intake on reta/tirz to lose the last 10kg. This is despite a diet with absolutely minimal blood glucose variation, very high protein , no high glycaemic index foods and a hb1ac of 5 to start with and on reta /tirz of 4.5, so there is good evidence of metabolic state improvements,

And this is where I posit the strategy of choosing the appropriate counter, instead of playing incessant defense. What I mean is, if GLP's mandate hunger suppression, but no cure, then maybe one could try doing the opposite of what fat cells do. Use metabolically active tissues to counter by building as much muscle as possible. Muscles consume energy, but raise our TDEE too, giving us more latitude in daily calorie consumption. Also, the myokines produced by muscles do include those that elevate metabolism, such as Irisin.

 

[birdwhacker]

How has epithalon been for you? I’ve been wanting to try it myself!

I think I like it, I'll have to get back to you though. This is only the third night for me.

If you like dreams, DSIP was a big winner for me! Not worth the money honestly but I got it for free. I'm excited to cycle it after I finish with the epitalon

 

[bonelifts]

I have quite a few experienced peptide adepts saying that less is more in order to maintain longer tolerance and effects. Interested to hear your perspective and experience.

I guess the less is more depends on the peptide itself. Those that have impact on receptors for sure could be impacted by increased and ongoing use, as over time that impact will diminish. There are others that don’t impact receptors as part of use and those probably can be used long term or in higher reasonable doses.

 

[Smiter]

Not worth the money honestly but I got it for free

Is your gang looking for new initiates?

 

[birdwhacker]

Is your gang looking for new initiates?

Depends, do you know how to work an iron?

Jk, I ordered KPV from HKMS and they accidentally sent me two kits of DSIP. They replaced the KPV and I am super satisfied LOL.

Peep today's order. I'm gonna dry scoop the SLU without a scale. I heard it has zero human studies, excited to try it. Taking SLU instead of cardarine is like eating fruity pebbles when what you're really craving is aquarium gravel.

 

[Smiter]

I ordered KPV from HKMS and they accidentally sent me two kits of DSIP. They replaced the KPV and I am super satisfied LOL.

Has your martial arts school managed to perfect the art of making the vendors accidentally deliver the wrong product? Very Sun Tzu-esque of you. And the vendors are Chinese, so it fits. With that luck of yours, you should head to Vegas; pole-dancers will find themselves falling from broken poles straight onto your lap

 

[Neptide]

I guess the less is more depends on the peptide itself. Those that have impact on receptors for sure could be impacted by increased and ongoing use, as over time that impact will diminish. There are others that don’t impact receptors as part of use and those probably can be used long term or in higher reasonable doses.

Absolutely . It really does depend on the peptide. The key, I suppose, is to find the right approach/protocol to cycling on and off.

 

[lessthanhalf]

As mentioned by others earlier, I think that even if the adipose tissue loses all its cytoplasm, the shells remain metabolically active. What do you reckon? Would people who do liposuction AFTER the weight loss- removing what's left, fare better in this regard? I have been doing research on leptin resistance for a long time, albeit secondary. The logical state of this context hits my brain too harshly to ignore.

I looked it up as I have not read much about liposuction and vaguely remembered people tend to regain the weight removed. It is not quite as clear cut as that but at least 50% do regain a lot of the removed weight, just somewhere else. And it can improve blood test biomarkers that originate from fat cells, but the effect is not long term, and there seem to be very few long term studies on it. So I don't think you can just suck out all the fat cells depleted or not and get rid of the unhelpful signalling.

The problem with leptin and ghrelin, etc, is that research on appetite and weight regulation discovers more and more systems and neurotransmitters and hormones and micro rnas continuously , as well as ever more complex brain circuitry controlling them, and while parts of the system are understood, I don't really think it can be said to be known yet what goes on to control weight , appetite and eating. I saw a paper recently trying to compare 4 different fundamental principles the system might work on, weight set point theory etc, and they really cannot even answer that question yet. And current knowledge would be a very large page of different systems , chemicals, cells , interactions and feedback loops with hundreds of components.

 

[WLBLD]

I looked it up as I have not read much about liposuction and vaguely remembered people tend to regain the weight removed. It is not quite as clear cut as that but at least 50% do regain a lot of the removed weight, just somewhere else. And it can improve blood test biomarkers that originate from fat cells, but the effect is not long term, and there seem to be very few long term studies on it. So I don't think you can just suck out all the fat cells depleted or not and get rid of the unhelpful signalling.

The problem with leptin and ghrelin, etc, is that research on appetite and weight regulation discovers more and more systems and neurotransmitters and hormones and micro rnas continuously , as well as ever more complex brain circuitry controlling them, and while parts of the system are understood, I don't really think it can be said to be known yet what goes on to control weight , appetite and eating. I saw a paper recently trying to compare 4 different fundamental principles the system might work on, weight set point theory etc, and they really cannot even answer that question yet. And current knowledge would be a very large page of different systems , chemicals, cells , interactions and feedback loops with hundreds of components.

I've read a little about it. Supposedly the fat cells that are removed don't come back but the ones that are left can become larger. I was curious. I heard its very painful though, so prob not worth it!!

 

[Mz-Ace]

You mean I could potentially manage my urges?

Epic failure on my behalf then

 

[Smiter]

Supposedly the fat cells that are removed don't come back but the ones that are left can become larger.

thats why I am using Adipotide and AOD before I get on Tesa while on Reta.

 

[myopicmystic]

I am indecisive on adding too much. Still just on tirz for now.

I’m interested in doing a mitochondrial protocol at least once. I also want to try a cycle of KLOW. Semax and selank also have my eye.

But I’m not sure if that’s the hyper fixation talking or if it’s transferring over from whatever addictive habits I had with food. So I’ll sit on it until I sort out which one it is.

 

[LongevitybroTX]

I am indecisive on adding too much. Still just on tirz for now.

I’m interested in doing a mitochondrial protocol at least once. I also want to try a cycle of KLOW. Semax and selank also have my eye.

But I’m not sure if that’s the hyper fixation talking or if it’s transferring over from whatever addictive habits I had with food. So I’ll sit on it until I sort out which one it is.

That's been my problem too, I'm curious to try quite a few things, but am also the type that wants to know anything and everything about each one, and not stack too much at any given time as I want to be able to know what's not working well for me. Also, shit adds up fast $$! ha!

 

[Smiter]

It only started as one pin a week. Now it is 6 pins daily. Let's just say the stack has grown. It is like the movie Groundhog Day. Switch 80% of them to Glutes. Belly was getting tender and lumpy.

GHK-cu ( 6 months)

Tesamorelin ( Until I can see a shadow of my Kidney)

5-Amino-1mq ( 30 days) 2-week break

AOD-9604 ( 60 days) 2-week break

SS-31 ( 30 days) then MOTS-c ( every other day)

KPV (Everyday)

Tirz (Once a week)

To a regular person, I would look like a psycho, but to you guys and girls, just another day at the office.

Geez! With a shot-stack like that, it's a wonder you have a sack to chew on.

AOD? I want to try it

Forget it. It doesn't work.

Need to learn GB's. I feel left out.

I'm with you. Let's start our own group...The Leftouts.

AOD. I’m going to try it. Seems from what I hear, the best way is to take it fasted and then go to the gym

Na, the best way to take it is to forget about it.

I'm hoping someone will develop a peptide that curbs my appetite to order more kits. I'd buy 10 kits of a peptide like this.

There is.. CharitAx-500. You keep sending 500usd to me everytime your hunger to order more kits takes over. It's a guaranteed cure.