Knocked me out!

[TeresaHip]

I've been taking cag .50 mg. It wasn't to bad at that dose so I decided to up to 1 mg. HUGE mistake! It knocked me for a loop. I basically slept for 2 days and barely ate. It knocked my appetite completely. Cag is a wonderful add on if you keep the dose low. I take tirz on Sunday and cag on Wednesday. At the smaller dose I was doing fine so I'm going back down and keep it there.

 

[Calm Logic]

How long were you on 0.5 mg before titrating up?

 

[TeresaHip]

How long were you on 0.5 mg before titrating up?

About 3 months. I started at .25

 

[Smiter]

Ok, it's official..Henceforth, Cagri will be Iron Mike.

 

[Calm Logic]

At the smaller dose I was doing fine so I'm going back down and keep it there.

Ditto. When I go back to cagri, a long cruise at 300 mcg for me.

I basically slept for 2 days and barely ate. It knocked my appetite completely.

Related post yesterday about cagri:

I’ve gotten to 5mg/wk and can confirm, still breaks stalls and fatigue continues. It is usually pretty bad the two days following the injection and then chills out for the remainder of the week. A quick nap does wonders for it though.

 

[CMA Pooky]

Ok, it's official..Henceforth, Cagri will be Iron Mike.

Mama said knock you out!

View: https://youtu.be/vimZj8HW0Kg?si=UhxM5CFx41Eq5O9h

 

[chipsandsalsayall]

I recently upped from 125mcg to 250 mcg and felt some fatigue for a day or so...can't attribute it to anything else...going to push on through because I do respond to it with tirz...

 

[Grogu]

I've been taking cag .50 mg. It wasn't to bad at that dose so I decided to up to 1 mg. HUGE mistake! It knocked me for a loop. I basically slept for 2 days and barely ate. It knocked my appetite completely. Cag is a wonderful add on if you keep the dose low. I take tirz on Sunday and cag on Wednesday. At the smaller dose I was doing fine so I'm going back down and keep it there.

Thanks for this information! Sorry that Cagri knocked you out.

I’ve had some extreme tiredness at night on .5mg this past week so I’m definitely going to take my time titrating up. So, very useful info!

 

[gunmetal1991]

I must be the exception. Been on cag maybe 8 weeks and am on 1.2mg and not having any tiredness. Appetite suppression is there but not too strong (eat between 1400-2000 cals a day, 10-20k steps a day) also on 12.5mg tirz and get full quicker.

However because I use tirz its hard to see if thats more Cag or tirz. I wassnt getting much on tirz alone so I think its more Cag at the moment.

Im feeling fine on my dose (tirz friday, cag monday) so not thinking of going up anytime soon.

 

[Grogu]

I must be the exception. Been on cag maybe 8 weeks and am on 1.2mg and not having any tiredness. Appetite suppression is there but not too strong (eat between 1400-2000 cals a day, 10-20k steps a day) also on 12.5mg tirz and get full quicker.

However because I use tirz its hard to see if thats more Cag or tirz. I wassnt getting much on tirz alone so I think its more Cag at the moment.

Im feeling fine on my dose (tirz friday, cag monday) so not thinking of going up anytime soon.

That's great that you haven't experienced any of the fatigue. I tried cagri about 2 months ago for a couple of weeks and had no side effects and mild appetite supression. This time, .5mg is kicking my ass and I haven't thought about food since pinning.

Something in your post makes me wonder if my fatigue this time is because I pinned both on the same day. Last go around, I split the doses like you do. But this time, I figured that since they dose cagrisema on the same day, why not do the same. Tomorrow is shot day, so I think I'll just take my tirzepatide dose on it's own and hold off on the cagri until Monday.

 

[ThatNextGril]

Something in your post makes me wonder if my fatigue this time is because I pinned both on the same day. Last go around, I split the doses like you do. But this time, I figured that since they dose cagrisema on the same day, why not do the same. Tomorrow is shot day, so I think I'll just take my tirzepatide dose on it's own and hold off on the cagri until Monday.

You definitely need to keep us updated when you do. If ensuring you take the tirz and cagri on different days helps alleviate the exhaustion, that's a cheat code we all need to know about! I'm hoping you're right!

 

[joseblo]

You definitely need to keep us updated when you do. If ensuring you take the tirz and cagri on different days helps alleviate the exhaustion, that's a cheat code we all need to know about! I'm hoping you're right!

It's pretty common to offset days when stacking GLPs. Mostly, because it helps spread out the "food noise" suppression. So Tirz (wait 3 days) Cagri/Survo/Maz. It lets me keep dosage low. The only time I move them around is when I know I'm going out for a nice dinner and WANT to be able to eat EVERYTHING. Note, I'm on maintenance YMMV.

 

[Grogu]

You definitely need to keep us updated when you do. If ensuring you take the tirz and cagri on different days helps alleviate the exhaustion, that's a cheat code we all need to know about! I'm hoping you're right!

I'll definitely post how it goes next week with the fatigue. I'm hoping that I can survive this side effect. Strangely, now that I know it's a side, I've resisted closing my eyes and falling asleep and have been okay.

It's pretty common to offset days when stacking GLPs. Mostly, because it helps spread out the "food noise" suppression. So Tirz (wait 3 days) Cagri/Survo/Max. It lets me keep dosage low. The only time I move them around is when I know I'm going out for a nice dinner and WANT to be able to eat EVERYTHING. Note, I'm on maintenance YMMV.

Yes, normally I would have split my doses with days in between. When I stacked with sema last fall, I did that three days apart. I honestly don't know what gave me the brainstorm (or rather dumb idea ) to pin the cagri right after my tirz shot. I think I was looking at the cagrisema clinicals and figured why not , now I know why not.

 

[CJsMom]

I tried Cagri 2 weeks ago at .250. The first day was fine, but day 2 - no energy. Not sleepy, just overwhelmingly tired. It was so bad I skipped it the next week. Tried it again this week at .170. So far, so good. Cagri is strong stuff.

 

[Smiter]

I must be the exception. Been on cag maybe 8 weeks and am on 1.2mg and not having any tiredness.

Ok, you're Holyfield then...protect your ears, eh?

I tried Cagri 2 weeks ago at .250. The first day was fine, but day 2 - no energy. Not sleepy, just overwhelmingly tired. It was so bad I skipped it the next week. Tried it again this week at .170. So far, so good. Cagri is strong stuff.

So Elora will be killer then, eh?

pin the cagri right after my tirz shot.

are you familiar with living la vida loca?.

 

[ambot88]

I've been taking .5 about 3 days after 5mg reta and I do think it's causing some fatigue but nothing unmanageable. I like to take the cagri at night so I can sleep off the initial fatigue and then I pin MOTS-C the next morning and I feel like that helps too.

 

[Grogu]

I tried Cagri 2 weeks ago at .250. The first day was fine, but day 2 - no energy. Not sleepy, just overwhelmingly tired. It was so bad I skipped it the next week. Tried it again this week at .170. So far, so good. Cagri is strong stuff.

Maybe the .5mg was just too much to start for me. Are you pinning tirz or reta too? What days to you pin?

 

[CJsMom]

Maybe the .5mg was just too much to start for me. Are you pinning tirz or reta too? What days to you pin?

Tirz 10mg Monday and the Cagri on Thursday, so yesterday. Today I feel OK so next week I might try .250 again.

 

[CJsMom]

Ok, you're Holyfield then...protect your ears, eh?

So Elora will be killer then, eh?

are you familiar with living la vida loca?.

I am in no rush for the Elora. I like Tirz and have enough to last for a few years, so it is unlikely that I will changing unless I get to max dose, and it stops working. Hopefully by then they will have worked out all the Elora kinks in testing, etc.

 

[indolent]

I'd never consumed any peptide other than tirzepatide, but stalled for months now with 30 pounds to go. Monday of this week I had my usual 7.5 mg of tirz (concluding my 3.5-day split; going back to 15 mg 1/week on the upcoming Monday).

Wednesday first-ever cagrilintide, at 0.25mg. Thursday evening compelling nodding-off. Thursday night: 11 hours of solid and delightful sleep.

This would worry me greatly if I had to drive when that effect hit.

But no other discernible effects, so far: no appetite suppression; no GI issues