剂量最高可达 4 毫克或 3 毫克？

[Daisbuys]

目前我服用瑞达（Reta）已经8周了，也是第一周体重没有下降！

前4周每天服用

1毫克，接下来的4周每天服用2毫克

，每周减重1公斤，直到今天。

我原本打算接下来4周服用3毫克，但这周体重没有变化，所以我

现在在考虑是否直接增加到4毫克？我

的计划是先服用3毫克一周，然后在服用瑞达的第二周开始服用特沙莫瑞林（Tesamorelin），疗程为8周。

我应该坚持原计划，还是直接增加到4毫克（我原本打算再服用4周）？

 

[CMA Pooky]

我只是根据自己的亲身经历来说。我从2.5毫克增加到4毫克，减肥效果很明显。我的剂量依次是1毫克、2毫克、2.5毫克、4毫克、5毫克，现在是6毫克。

 

[woundcarping]

两种方式都无所谓。

 

[matt400]

对于我的RS，我会做3次，持续1周，看看结果（是否有效，耐受性如何），如果我不满意，下一周就增加到4次。

 

[latviantower]

目前我服用瑞达（Reta）已经8周了，也是第一周体重没有下降！

前4周每天服用

1毫克，接下来的4周每天服用2毫克

，每周减重1公斤，直到今天。

我原本打算接下来4周服用3毫克，但这周体重没有变化，所以我

现在在考虑是否直接增加到4毫克？我

的计划是先服用3毫克一周，然后在服用瑞达的第二周开始服用特沙莫瑞林（Tesamorelin），疗程为8周。

我应该坚持原计划，还是直接增加到4毫克（我原本打算再服用4周）？

你肯定可以更快地增加瑞他莫昔芬的剂量。你目前的用药方案相当保守。我

只是好奇你的特沙坦治疗方案。为什么是3毫克，持续8周？我不是在批评你，只是我没见过这样的推荐疗程。我一直以来看到的“标准”方案是2毫克，服用5天停药2天（让受体重置，这一点很重要），持续6个月。他们就是这样给Egrifta（商品名特沙坦）开药的。3毫克不会有什么坏处，但我记得临床试验中读到过，内脏脂肪减少的效果并没有超过2毫克。（这样就帮你省了33%的特沙坦费用。不用谢。）

 

[BNLFL]

For me, 2mg to 4mg titration was the same at 3lbs a week. Pinning the 4th 4mg today, and I'll decided Monday if I want to stay on 4, or go to 6 -8mg depending on the scale. One thing is the belly issues, mainly are basically gone after 8 weeks on Reta. I started a low carb diet when starting on 1/9/26. I don't track calories, protein, etc. Breakfast is a hard boiled or fried egg and a sausage patty my wife makes, lunch is a protein shake and dinner is some type of meat (fish, beef, pork, chicken) cottage cheese, sliced tomato or some steamed veggie. I do usually have 2-4 beers a day. My starting weight was 215lbs, last weigh in Monday was 195lbs. Target is 175.

 

[lessthanhalf]

Currently on my 8th week of Reta and first week of not dropping!

First 4 weeks were @1mg

Next 4 have been @2mg

And have lost 1kg every week until today.

I was going to go onto 3mg for the next 4 weeks, but after not budging the scales this week im

Now debating wether to just jump up to 4mg?

Plan was to do a week at 3mg and start an 8 week course of Tesamorelin on my 2nd week @3mg

Do I stick to plan or just jump up to 4mg which I wasn’t intending to do for another 4 weeks?

The answer depends on what side effects you have at your current dose. If you have any go up slowly to 3mg , if no side effects then 4mg. Neither guarantees you will not get more side effects after increasing the dose, but at least it makes sense to do it that way.

 

[yrrdead]

I'm with @woundcarping in that I don't think it will matter either way but..... I would say that it is relatively normal even with GLP1's to have an "off" week during any sort of calorie reduction. Now 2 or more weeks or if you are weighing more often and are really dialed with data we could delve into that.

In addition it really grinds my gears in every one of these threads there is zero mention of diet/calorie intake. Kind of a forest for the trees situation. I blame the cheap drugs.

 

[Jfrick11]

Currently on my 8th week of Reta and first week of not dropping!

First 4 weeks were @1mg

Next 4 have been @2mg

And have lost 1kg every week until today.

I was going to go onto 3mg for the next 4 weeks, but after not budging the scales this week im

Now debating wether to just jump up to 4mg?

Plan was to do a week at 3mg and start an 8 week course of Tesamorelin on my 2nd week @3mg

Do I stick to plan or just jump up to 4mg which I wasn’t intending to do for another 4 weeks?

If you are already losing 1 kg per week, that dose is doing exactly what it’s supposed to do. One week without movement isn’t a plateau, it’s just normal body fluctuation. Jumping doses too fast usually just increases side effects and shortens how long the medication stays effective. Slow and steady actually wins here.

 

[woundcarping]

In addition it really grinds my gears in every one of these threads there is zero mention of diet/calorie intake. Kind of a forest for the trees situation. I blame the cheap drugs.

How about starting weight, current weight, target weight, and goals being frequently being left out also.

 

[BNLFL]

In addition it really grinds my gears in every one of these threads there is zero mention of diet/calorie intake. Kind of a forest for the trees situation. I blame the cheap drugs.

How about starting weight, current weight, target weight, and goals being frequently being left out also.

Great points. I edited my post.

 

[ArgFdzPep]

Currently on my 8th week of Reta and first week of not dropping!

First 4 weeks were @1mg

Next 4 have been @2mg

And have lost 1kg every week until today.

I was going to go onto 3mg for the next 4 weeks, but after not budging the scales this week im

Now debating wether to just jump up to 4mg?

Plan was to do a week at 3mg and start an 8 week course of Tesamorelin on my 2nd week @3mg

Do I stick to plan or just jump up to 4mg which I wasn’t intending to do for another 4 weeks?

Probably better to titrate up slower, that’s not to say you can’t jump to 4, you may just experience the side effects a bit more acutely, also have you modified your diet after a while? Sometimes that’s a game changer as well as you titrate.

 

[Jerrey]

If you are already losing 1 kg per week, that dose is doing exactly what it’s supposed to do. One week without movement isn’t a plateau, it’s just normal body fluctuation. Jumping doses too fast usually just increases side effects and shortens how long the medication stays effective. Slow and steady actually wins here.

100% correct! Only being 8 weeks in and this being the first week to not see a drop its easy to let emotions drive a response. Don't be shaken by it you need to play the long game not make knee jerk reactions always error on the side of caution. Go slow and steady and you will have better long term performance.

 

[Daisbuys]

Thank you all for the replies, appreciate them all thank you.

It was quite a rushed post as was doing it in between working but should have put more information in regardless.

Tesamorelin will be at 2mg 5/2. Was just badly written.

Starting weight 105kg

Current 98kg

Target 90kg

800 calorie deficit

Weights x 3 per week

Cardio x 2 per week

Currently away for the weekend so diet will be out the window, which maybe the reset the body needs?

Think I will jump on 3mg as planned, slowly slowly catch a monkey

Thanks again all for your replies