Itching, nausea

[Strawberrykitten]

My Reta 48 kit I got from them was actually Reta 58! Thank god my first pin was only 1 mg before I got the COA.

I just checked and it was 65 so it was probably more than I could handle. I'm just going to stop for now and try to see how I feel.

 

[Not_Your_Dad]

I just checked and it was 65 so it was probably more than I could handle. I'm just going to stop for now and try to see how I feel.

That 65 almost had you skipping your 10 mg pin and going right to 12.5. It sounds like you might be sensitive to the higher doses of Tirz anyway and that was a large step.

Hope you get better soon!

 

[Good-Heart6425]

I followed the regular protocol of 2.5, 5, 7.5 (each dose I stayed on it for 4 weeks). I bought the 60 mg dose from Nexaph and used 3 ML of BAC water so I could have 6 (10 mg doses). I only used it 3 times (my husband uses it along with me and he hasn't had any issues. )

I had issues with itching all over before I started this but it was always associated with sugar consumption. Now that I have no cravings I''m not sure why the itching is coming back. It's worst when I first wake up in the morning. I've had all my lab work done. I see an endocrinologist and had my thyroid checked and it's all normal. The only issue I have is my CRP levels are high but so far no one has been able to figure out what's causing it.

I've had all kinds of issues since I started (when I first started at 2.5 mgs - my periods were lasting all month long, I was told it's normal and things are regulating. Weight loss wasn't the goal for me so at first I saw no weight loss but i was hoping things were regulating. I don't know what's going on. I've done all the testing that can be done and no one has any answers for me. Meanwhile, the fatigue is so intense, I'm sleeping for 20 hours in a day and not being able to function.

Side effects were very similar during my first 12 weeks of compounded T. Intense itching and welts on my torso esp where my skin was compressed by waistband and bra strap. Severe fatigue and sleepiness and hair loss. Constipation, no appetite, yet minimal weight loss. Dermatologist was unable to diagnose, but gave me 2 weeks of anti-histamine and prednisone, a miracle drug that seemed to solve everything. But, once my bowel function resumed, I had rapid weight loss!!! Retrospectively, I believe my adipose was transformed to a massive circulating volume of free fatty acids in my bloodstream that were being excreted through my lungs, kidneys, bowels and SKIN ! Hence the “ketosis rash!” What gave me relief: soaking/scrubbing in the bathtub’s hottest water, topical Vaseline, then aerobic bicycling 60 minutes, Vitamin C megadoses, NSAIDs, and anti-histamine pills. Since that time I’ve reached my goal weight and experienced reversal of co-morbidities and side-effects, so I’m at a lower dose of T to sustain my appetite suppression. I believe the ketone bodies irritated the pores of my skin most severely where it was compressed by my clothing.

Yet, I’m so glad I continued my GLP despite these side effects. A slower dose titration would have been better tolerated, for sure. It’s likely that my dosage titration was too fast for my body’s metabolic changes. If I had recognized the signals my body was giving, I could have reduced or avoided my discomforts.

 

[lessthanhalf]

Thanks for the medical info update. It sounds like you have enough doctors looking after you, it is really hard to guess at what is going on with a tiny percentage of the full story on a forum. Unfortunately not all medical issues have straightforward diagnoses and treatments that always work, and everyone just has to muddle along as best they can. But most problems do get better over time. I would still be inclined to stop the tirzepatide for a while at least to try to separate out if it is causing some of the tiredness etc. I certainly had nausea and a low grade generally unwell feeling for about a year on semaglutide, which thankfully I don't get on tirzepatide, but side effects seem very variable and individual. And if and when you want to restart it going extra low and slow with dosing would be a good idea.

 

[Strawberrykitten]

Side effects were very similar during my first 12 weeks of compounded T. Intense itching and welts on my torso esp where my skin was compressed by waistband and bra strap. Severe fatigue and sleepiness and hair loss. Constipation, no appetite, yet minimal weight loss. Dermatologist was unable to diagnose, but gave me 2 weeks of anti-histamine and prednisone, a miracle drug that seemed to solve everything. But, once my bowel function resumed, I had rapid weight loss!!! Retrospectively, I believe my adipose was transformed to a massive circulating volume of free fatty acids in my bloodstream that were being excreted through my lungs, kidneys, bowels and SKIN ! Hence the “ketosis rash!” What gave me relief: soaking/scrubbing in the bathtub’s hottest water, topical Vaseline, then aerobic bicycling 60 minutes, Vitamin C megadoses, NSAIDs, and anti-histamine pills. Since that time I’ve reached my goal weight and experienced reversal of co-morbidities and side-effects, so I’m at a lower dose of T to sustain my appetite suppression. I believe the ketone bodies irritated the pores of my skin most severely where it was compressed by my clothing.

Yet, I’m so glad I continued my GLP despite these side effects. A slower dose titration would have been better tolerated, for sure. It’s likely that my dosage titration was too fast for my body’s metabolic changes. If I had recognized the signals my body was giving, I could have reduced or avoided my discomforts.

Everything you are describing here is pretty much what I'm going through minus constipation. I think I'm not constipated because of the magnesium glycinate I take every night. The itching is intense when I undress so that makes sense. I'm going to take a break for a few weeks though because I just feel like junk right now, I'll have to try back at a lower dose and see how I do. Thanks again for sharing

 

[Good-Heart6425]

Everything you are describing here is pretty much what I'm going through minus constipation. I think I'm not constipated because of the magnesium glycinate I take every night. The itching is intense when I undress so that makes sense. I'm going to take a break for a few weeks though because I just feel like junk right now, I'll have to try back at a lower dose and see how I do. Thanks again for sharing

I think the uticaria [“ketosis rash”] is considered to be very rare. My skin type is very pale, never tans, no melanin, aka FitzPatrick one. Dermatologist did not recognize my symptoms, but I did not share my recent history of months of self injected T. That was >6 months ago. Still taking daily low dose of antihistamine . Now have titrated down to maintenance T dose for appetite suppression

 

[Good-Heart6425]

Everything you are describing here is pretty much what I'm going through minus constipation. I think I'm not constipated because of the magnesium glycinate I take every night. The itching is intense when I undress so that makes sense. I'm going to take a break for a few weeks though because I just feel like junk right now, I'll have to try back at a lower dose and see how I do. Thanks again for sharing

Additionally, my belief is that similar to my torso skin, my scalp pores were irritated by the exiting ketone bodies as well. A lot of hair fell out . Now it’s growing back ; hooray,farewell alopecia!

 

[Strawberrykitten]

I think the uticaria [“ketosis rash”] is considered to be very rare. My skin type is very pale, never tans, no melanin, aka FitzPatrick one. Dermatologist did not recognize my symptoms, but I did not share my recent history of months of self injected T. That was >6 months ago. Still taking daily low dose of antihistamine . Now have titrated down to maintenance T dose for appetite suppression

Well I'm Indiam so lots of melanin and I've brown skin so that's not similar