Strawberrykitten said:
I followed the regular protocol of 2.5, 5, 7.5 (each dose I stayed on it for 4 weeks). I bought the 60 mg dose from Nexaph and used 3 ML of BAC water so I could have 6 (10 mg doses). I only used it 3 times (my husband uses it along with me and he hasn't had any issues. )
I had issues with itching all over before I started this but it was always associated with sugar consumption. Now that I have no cravings I''m not sure why the itching is coming back. It's worst when I first wake up in the morning. I've had all my lab work done. I see an endocrinologist and had my thyroid checked and it's all normal. The only issue I have is my CRP levels are high but so far no one has been able to figure out what's causing it.
I've had all kinds of issues since I started (when I first started at 2.5 mgs - my periods were lasting all month long, I was told it's normal and things are regulating. Weight loss wasn't the goal for me so at first I saw no weight loss but i was hoping things were regulating. I don't know what's going on. I've done all the testing that can be done and no one has any answers for me. Meanwhile, the fatigue is so intense, I'm sleeping for 20 hours in a day and not being able to function.
Thank you for explaining more, that helps a lot. Based on everything you’re describing, this really doesn’t sound like a simple or “normal” GLP-1 adjustment issue.
A few important things stand out:
You already had baseline itching and elevated CRP, which points to an underlying inflammatory or histamine-driven process.
Tirzepatide can amplify inflammation or histamine responses in some people, even when standard labs (thyroid, etc.) look normal.
The extreme fatigue (sleeping up to 20 hours/day), body aches, and worsening itching are not typical and not something to push through.
The prolonged bleeding early on suggests your system was under significant stress from the start.
One important thing I want to say clearly: it is not actually a requirement or “rule” to increase the dose every month. Increasing monthly often means forcing more medication when the body may not need it or tolerate it, especially when weight loss isn’t the only goal.
For PCOS and metabolic regulation, the right dose is the lowest dose that improves labs and symptoms , not the highest tolerated dose. Appetite suppression is not the goal, stability is.
Given how systemic and disabling these symptoms are, I would strongly consider stopping the medication entirely for now , not just lowering the dose, and allowing a full reset. If symptoms improve off it, that’s critical information. If they don’t, it suggests something else inflammatory is driving this that the medication is worsening or unmasking.
Even though your husband is doing fine, bodies can react very differently, especially with PCOS and baseline inflammation.
You’re not doing anything wrong, and you’re not imagining this. Your body is giving clear signals that something here isn’t right, and listening to that is the smart move.
