Is Pro Advice Worth It?

[Calm Logic]

KPV is extremely popular in my circle as well as at this forum, including stacked with TA-1.

Also:

KPV has demonstrated antimicrobial properties, specifically against Staphylococcus aureus and Candida albicans, which adds a layer of utility that BPC-157 lacks.

Anyone on MOTS-c and SS-31 may want to be on CoQ10 as well, which many are already, but there's always more supplements contending for cabinet space:

The Mighty Mitochondria - SSRP Institute

ssrpinstitute.org

If you are looking for ways to support mitochondrial biogenesis (a fancy way of saying ‘help your body make more mitochondria’) there are several well researched supplements that may help.

Here are some of the top contenders:

Resveratrol – This polyphenol found in red wine activates the AMPK-SIRT1-PGC-1α pathway that initiates mitochondrial biogenesis.

Coenzyme Q10 (CoQ10) – A component of the electron transport chain, CoQ10 supports mitochondrial energy production.

Alpha-Lipoic Acid (ALA) – A potent antioxidant that enhances mitochondrial function and may be useful for various conditions associated with mitochondrial dysfunction.

L-Carnitine – Facilitates the transport of fatty acids into the mitochondria to produce energy.

Creatine – Well known for its benefits in high intensity exercise, creatine improves mitochondrial efficiency.

B-Vitamins – B3, B6, B12, and folic acid, which serve as essential cofactors in mitochondrial function.

Magnesium – Important in ATP production and over 300 biochemical reactions in the body including those occurring in the mitochondria.

Berberine – A natural product that stimulates mitochondrial biogenesis through the AMPK-SIRT1-PGC-1α pathway.

Epigallocatechin-3-gallate (EGCG) – An antioxidant from green tea that stimulates mitochondrial biogenesis.

These supplements vary in their effect from individual to individual, but most of them activate PGC-1α, which is the master regulator of mitochondrial biogenesis. When you are educating your patients on how they can help support mitochondria health and redox balance through supplements, check out my second book, The Redox Promise, where I discuss numerous other supplements that can benefit cellular health. Look for it!

References:

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https://www.mdpi.com/2076-3921/13/5/613

Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE - Molecular Psychiatry

Mitochondrial DNA variants have previously associated with disease, but the underlying mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 associated with Alzheimer’s disease (AD), neuroimaging, and transcriptomics. We mapped rs2853499 to a novel mitochondrial...

www.nature.com

https://pmc.ncbi.nlm.nih.gov/articles/PMC10027624/

NAD+ is often stacked these peptides. But the only thing that I know Dr. Seeds to be critical of is NAD+:

Why NAD Supplementation Isn't Beneficial - Redox Medical Group

By now, you may have come across numerous claims regarding the potential benefits of supplementing with nicotinamide adenine dinucleotide (NAD+). While it is

redoxmedicalgroup.com

Even testing NAD+ levels in the blood doesn't tell you how much actually gets into the cells:

Because red blood cells lack mitochondria, their NAD+ levels don't reflect the metabolic activity or "fuel status" of your heart, liver, or skeletal muscle—the areas where you’re likely looking for performance or anti-aging benefits.

Even within a single cell, NAD+ is compartmentalized into different "pools" (cytoplasm, nucleus, and mitochondria). A blood test cannot distinguish between these. You might have "adequate" total levels, but if your mitochondrial NAD+ pool is depleted, your cellular energy production (ATP synthesis) will still lag.