Immediate reaction after 0.5mg injection

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exxn66

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Hi everyone I wanted to share an experience I just had with my injection of 0.5mg to see if anyone has encountered something similar.

Immediately after the injection, I experienced a sudden onset of body warmth and a noticeable increase in heart rate. I also noticed a brief swelling at the injection site right after pulling the needle out.

The needle felt a bit blunt during entry, i used the same the needle when getting out the reta from the vial. When I withdrew it, a small drop of blood appeared at the site.

The swelling at the injection site subsided relatively quickly and has calmed down since.

Has anyone else experienced an immediate systemic reaction like warmth or increased heart rate? I know Reta usually takes longer to peak.
 
How long is this insulin needle? Did you inject at 90 degrees (straight in) or at an angle?

You injected where exactly?

Have you used this vial/kit before?

exxn66 said:
When I withdrew it, a small drop of blood appeared at the site
That's normal.
 
exxn66 said:
Hi everyone I wanted to share an experience I just had with my injection of 0.5mg to see if anyone has encountered something similar.

Immediately after the injection, I experienced a sudden onset of body warmth and a noticeable increase in heart rate. I also noticed a brief swelling at the injection site right after pulling the needle out.

The needle felt a bit blunt during entry, i used the same the needle when getting out the reta from the vial. When I withdrew it, a small drop of blood appeared at the site.

The swelling at the injection site subsided relatively quickly and has calmed down since.

Has anyone else experienced an immediate systemic reaction like warmth or increased heart rate? I know Reta usually takes longer to peak.
Sounds like a vasovagal response to the injection, not anything to do with Reta.
 
Calm Logic said:
How long is this insulin needle? Did you inject at 90 degrees (straight in) or at an angle?

You injected where exactly?

Have you used this vial/kit before?

That's normal.
31g 6mm. straight in i think, maybe slight angle.

7-8 cm besides my belly button.

no first time i used it. i did filter it before with a pes 0.22µm filter and put it in a new vial.
 
yrrdead said:
Sounds like a vasovagal response to the injection, not anything to do with Reta.
never had a problem before. i was injecting tirzepatid before with no problem with the pen and also with an insulin syringe (golden dose). maybe it was the dull syringe? i had some resistance which i normally dont have when injecting.
 
exxn66 said:
maybe it was the dull syringe? i had some resistance which i normally dont have when injecting.

Google Gemini:

quoted said:
The intense pain or the anxiety of struggling with the needle causes the adrenal glands to release epinephrine (adrenaline).

quoted said:
Heart Rate: Adrenaline directly signals the heart to beat faster and more forcefully to prepare the body for "danger."

quoted said:
Body Warmth: This surge causes vasodilation in certain areas and a sudden increase in metabolic activity, which you feel as a "flush" or sudden heat.
 
Wasn’t there an alleged bad batch of Reta?
 
I have always wondered, if you inject Reta and hit a blood vessel in the fat, whether that would make you feel some immediate results.
 
Calm Logic said:
Google Gemini:
so just swicht the needle after taking it out of the vial and it should be good?

deleted.user.16 said:
I have always wondered, if you inject Reta and hit a blood vessel in the fat, whether that would make you feel some immediate results.
Yeah I think I hit a blood vessel. I started feeling the hunger suppression just a few hours later, and I also noticed a higher heart rate, which I believe is normal with Reta.
 
CallieKat said:
Wasn’t there an alleged bad batch of Reta?
Not that I'm aware of.

exxn66 said:
so just swicht the needle after taking it out of the vial and it should be good?
I've never done that, and you'll need a luer lock syringe with extra needles. What brand of syringes are you using?
 
exxn66 said:
Hi everyone I wanted to share an experience I just had with my injection of 0.5mg to see if anyone has encountered something similar.

Immediately after the injection, I experienced a sudden onset of body warmth and a noticeable increase in heart rate. I also noticed a brief swelling at the injection site right after pulling the needle out.

The needle felt a bit blunt during entry, i used the same the needle when getting out the reta from the vial. When I withdrew it, a small drop of blood appeared at the site.

The swelling at the injection site subsided relatively quickly and has calmed down since.

Has anyone else experienced an immediate systemic reaction like warmth or increased heart rate? I know Reta usually takes longer to peak.
Did you recently reconstitute? Very strange symptoms so suddenly
 
exxn66 said:
I also noticed a higher heart rate, which I believe is normal with Reta.
Higher heart rate is something you can objectively measure and quantify. Otherwise, the "feeling of" may be attributed to anxiety, which can itself increase heart rate.

When you inject, hesitation can be a factor for an unpleasant experience. I did a better job injecting when I started than when I got lax with my technique. So maybe that is a factor, but I am reluctant to conclude anything since it is a new kit? Or just a new vial from an existing kit? Or did you buy single vials?
 
Calm Logic said:
Higher heart rate is something you can objectively measure and quantify. Otherwise, the "feeling of" may be attributed to anxiety.
Minimal in my case. Normally about 72-76 I guess, been running around 76 lately. Cardiologist tomorrow. We'll see if he catches anything. They'll for sure be comments on my weight. I was 207 last years appointment and probably 182-183 tomorrow. I peaked at 215 in Dec-Jan when I started this stuff. I bet he figures it out, he's a tad younger.
 
exxn66 said:
Immediately after the injection, I experienced a sudden onset of body warmth and a noticeable increase in heart rate. I also noticed a brief swelling at the injection site right after pulling the needle out.

The needle felt a bit blunt during entry, i used the same the needle when getting out the reta from the vial. When I withdrew it, a small drop of blood appeared at the site.
It may be helpful for you to read this recent thread by Tbagger.

Different peptide but alarming experience nonetheless. It is good we have community support here!

[archived internal link]

Tbagger said:
That was the craziest reaction I've ever had to any peptide/medication/drug. I guess I accidentally IV'd my pin. It really shook me up and I sat there involuntarily shaking for a solid 5min afterward.
​[archived internal link]
 
Vriende said:
It may be helpful for you to read this recent thread by Tbagger.

Different peptide but alarming experience nonetheless. It is good we have community support here!

[archived internal link]

NAD+ is definitely the issue there. The worst seems to be MOTS-c by IM. Anyone using MOTS-s by IM seems crazy to me. CJC w/ ipa is also known for bad, systemic reactions.

exxn66 said:
31g 6mm. straight in i think, maybe slight angle.

7-8 cm besides my belly button.
For me using 6-mm syringe needles, laying the skin flat helps the most for comfort (with fatty abdominal areas). Occasionally injecting into my upper arm also works well, do nothing special. I always inject straight in with 6 mm, and I usually use a 45-degree angle for the 12.7 mm needles.
 
It is not impossible you managed to hit a vein, I'm pretty sure that has happened to me once, but logically the most likely thing is a reaction to the injection, just from the pain, or visible blood , or a bit of anxiety increasing sympathetic nervous system activity or a minor vasovagal response. Vasovagal responses can happen out of the blue to very minor triggers.
 
yrrdead said:
Sounds like a vasovagal response to the injection, not anything to do with Reta.
Vasovagal is the opposite symptoms, drop in BP and HR resulting in fainting episode. So it’s definitely not that
 
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