I'm 55 should I take Tesamorelin or just go for hgh and trt?

[UpDownLeftRightAS*]

This has unleashed a fantastic topical thread discussion! These insights are great and as most point out, IGF-1 increases differently for everyone. Certainly low HGH and Tesa are going to raise IGF, probably best to just cycle the Tesa. Personally, if I go to high on HGH I notice the water retention very quickly, I never go over 1.5iu daily (and when I cycled Tesa concurrently I took the hgh down to .5iu in the evenings with a wake up 1mg tesa fasted/mornings). TRT is something else entirely...but if your testosterone is low why not consider a low dose enclomine (6-12mg) first?

 

[bogardbilla]

Just an FYI , prescription tesa (brand name Egrifta) has a prescribed run time of 6 months, 2 mg 5&2. Target demographic HIV patients with diagnosed excessive visceral fat.

Do you have a source link for this? I can't find anything on Google.

 

[Zydeceltico]

Do you have a source link for this? I can't find anything on Google.

Really? Did you actually Google "Egrifta?" I suggest doing it again. LOL

https://www.ncbi.nlm.nih.gov/books/NBK539136/

 

[bogardbilla]

Really? Did you actually Google "Egrifta?" I suggest doing it again. LOL

https://www.ncbi.nlm.nih.gov/books/NBK539136/

That's a report referencing FDA study results, just because the FDA study lasted 26 weeks it doesn't mean that 6 months is the maximum recommended length of time to take Tesamorelin.

It doesn't seem to mention 5 days on 2 days off either (which other drug do you know of that is supposed to be taken only on workdays?)

I was hoping you had a link to dosage and prescription recommendations on Egrifta SV (which is the Tesamorelin we're all getting from China).

 

[Zydeceltico]

That's a report referencing FDA study results, just because the FDA study lasted 26 weeks it doesn't mean that 6 months is the maximum recommended length of time to take Tesamorelin.

It doesn't seem to mention 5 days on 2 days off either (which other drug do you know of that is supposed to be taken only on workdays?)

I was hoping you had a link to dosage and prescription recommendations on Egrifta SV (which is the Tesamorelin we're all getting from China).

Ahhhh....... I misinterpreted your post. As you likely well know - Google will return a multitude of articles regarding Tesamorelin and Egrifta and now I understand that you're looking for specifics.

Here you go: https://www.ncbi.nlm.nih.gov/books/NBK539127/

26 weeks; 2mg/day every day, NOT 5/2. And no - no max or min recommended either. And this is typical of the other clinical trials (with variance of course)

Give it a go. ymmv from mine.



(aside to myself mostly: I sometimes wonder what the percentage of folks is on this forum who do realize that we are all very literally just making up most of this as we go - LOL......one wonders)

 

[Calm Logic]

Certainly low HGH and Tesa are going to raise IGF, probably best to just cycle the Tesa.

Unless you are paranoid about antibodies, which is the easiest way I can justify HGH to my inner bro.

 

[wulf00777]

Definitely a lot to digest here. Unfortunately my hematocrit is sky high (59 before I gave blood) and I've had to take a break from test and reta. My numerous shipments are still chugging their way across the seas. Funny how a week turns into a month and 2 weeks equals 6 weeks. I'm in Colombia so it's very slow to ship here. And I finally hit retas sweet spot after 8 weeks!

 

[thorvald]

Tested my blood work igf1 (somatomedin c) from AOD 375mg in the morning and lv was over 300 after 3 weeks off usage daily

 

[Jone5y87!]

Definitely a lot to digest here. Unfortunately my hematocrit is sky high (59 before I gave blood) and I've had to take a break from test and reta. My numerous shipments are still chugging their way across the seas. Funny how a week turns into a month and 2 weeks equals 6 weeks. I'm in Colombia so it's very slow to ship here. And I finally hit retas sweet spot after 8 weeks!

Whats your sweet spot Dosage buddy ?

 

[Jone5y87!]

Thank you for the information. I am doing 2mg of Tesa daily on a 5x2 schedule. It is working great. I take it before bed after 3hrs of no food. I started with CJC/IPA but right away side effect, I switched to tesa after a month. No side effects, great sleep, muscle tone, energy, and fat burn have been great. I may try your schedule and see if there is any difference but probably won’t do CJC/IPA anytime soon though.

Why before bed please ?

My Tesa is on the boat so looking to get my protocols set ready in place for its arrival.

One of the peps im really looking forward to adding to my stack

 

[foffspam111]

For the GH secretagogues like tesa, age seems less important than biological sex, with males having greater response thanks to less estrogen but more "hepatic sensitivity." Same with HGH:

Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement - PubMed

GH production in healthy women is about thrice that in men. Yet insulin-like growth factor I (IGF-I) levels are similar, suggesting a lower responsivity to GH in women. In untreated GH-deficient adults, basal IGF-I levels are reportedly lower in females than in males, and the therapeutic...

pubmed.ncbi.nlm.nih.gov

So women may need 2 mg of tesa to get to the same IGF-1 (and visceral fat loss) of men on 1 mg of tesa (or 2 IU of HGH instead of 1 IU). And even with younger guys, response may be quite variable, since they have less to gain. (And women generally live longer, so they have the last laugh.)

My point on age is the more north of 40 you are the less efficient your body is, the better results you get from any peptide.

Why before bed please ?

My Tesa is on the boat so looking to get my protocols set ready in place for its arrival.

One of the peps im really looking forward to adding to my stack

its supposed to align with the pituitary glands natural pulse at night. The goal is to have tesa stimulate the gland during the natural cycle for more output of GH. People that have trouble sleeping while taking it usually switch to mornings fasted.

I have had some of the best sleep while on it. My results on it have been fantastic as well. Almost like a fountain of youth of sorts for me.

I hope you have the same if not better results than I have gotten!

 

[Jone5y87!]

My point on age is the more north of 40 you are the less efficient your body is, the better results you get from any peptide.

its supposed to align with the pituitary glands natural pulse at night. The goal is to have tesa stimulate the gland during the natural cycle for more output of GH. People that have trouble sleeping while taking it usually switch to mornings fasted.

I have had some of the best sleep while on it. My results on it have been fantastic as well. Almost like a fountain of youth of sorts for me.

I hope you have the same if not better results than I have gotten!

Thanks pal really appreciate this nighttime it is then

 

[SVT810E]

You can reset receptors using the Mon-Fri tesa 2 mg protocol, take the weekends off. Do that for 26 weeks. Added bonus, easy math. 10 mg vial lasts one week, 20 mg vial - two weeks.

Why would you want to though?

The pharmacokinetics trial for tesa found that continued use appeared to increase receptor sensitivity leading to a stronger growth hormone pulse at a given dose (although negative feedback mechanisms still worked to prevent excessive production).

So a 5-2 cycle might “reset receptors” but is the goal really to lower sensitivity back to baseline?

 

[latviantower]

Why would you want to though?

The pharmacokinetics trial for tesa found that continued use appeared to increase receptor sensitivity leading to a stronger growth hormone pulse at a given dose (although negative feedback mechanisms still worked to prevent excessive production).

So a 5-2 cycle might “reset receptors” but is the goal really to lower sensitivity back to baseline?

So maybe this is a case of trying to apply a “one size fits all” approach to tesamorelin that isn’t warranted? So many other protocols in our world recommend cycling to prevent receptor desensitization.

Pretty soon every pep will be a special use case.

 

[SVT810E]

So maybe this is a case of trying to apply a “one size fits all” approach to tesamorelin that isn’t warranted? So many other protocols in our world recommend cycling to prevent receptor desensitization.

Pretty soon every pep will be a special use case.

So many protocols in our world are based on thin scientific evidence (and too often not even that).

 

[MTSpace]

Why would you want to though?

The pharmacokinetics trial for tesa found that continued use appeared to increase receptor sensitivity leading to a stronger growth hormone pulse at a given dose (although negative feedback mechanisms still worked to prevent excessive production).

So a 5-2 cycle might “reset receptors” but is the goal really to lower sensitivity back to baseline?

What about a Tesa and HGH stack? 4/5 days Tesa and 2/3 days on HGH? Chat GPT gave me a HGH in th morning suggestion with Tesa at night?? Where did that come from?

 

[jason370]

I keep going back and forth. I already have hgh on order, I'm taking trt now, should I even bother with Tesa or ipa? Anyone have experience with both separate or together?

56 on Reta, KLOW, TRT, Tesa and Ipa and its working just fine.

 

[latviantower]

What about a Tesa and HGH stack? 4/5 days Tesa and 2/3 days on HGH? Chat GPT gave me a HGH in th morning suggestion with Tesa at night?? Where did that come from?

AI getting more creative all the time apparently.

Not sure how alternating an hgh secretagogue with actual hgh would work. I assume it would be highly dependent on what kind of hgh pulse the tesa is stimulating. It would be revealing to have the ability to continuously monitor serum IGF-1 (and autogenerate your individual Z score). The studies with HIV patients showed max IGF-1 increase (avg 81%) after 26 weeks of treatment - daily administration of 2 mg tesa, no weekly breaks.

I was always schooled that low dose hgh (1 iu for women, 2 iu for men) for anti-aging and body recomposition benefits was a long slow process. Don’t expect to see any results for six months. But if done in conjunction with TRT and combined with resistance training, that’s not exactly true - you will see improvement in the gym much sooner.

My personal experience has been that tesa and a GLP, exercise, calorie deficit, good protein intake and hydration led to significant weight loss. When I approached GW I transitioned to maintenance, cut out tesa, added daily doses of 2 iu hgh and 25 mg testosterone and increased strength training to 4x per week. BF decreased from 22 to 18%, goal being sub 15%. Glucose and IGF-1 staying in the green so far. (That’s another recommendation I’ve seen frequently- if adding exogenous hgh, use low dose reta to keep glucose in check and prevent insulin resistance.)

As always, YMMV.

 

[MTSpace]

What is your goal range for IGF and z-score? I should have my baseline for both back sometime within next week as I had bloodwork drawn yesterday. There is so much conflicting info on HGH but I like the conservative approach you have implemented as I am 58 and not looking to be 28 again. Seeking healthy longevity and higher quality of life in the present tense.

And when do you take your HGH and has your sleep improved?

 

[SVT810E]

What about a Tesa and HGH stack? 4/5 days Tesa and 2/3 days on HGH? Chat GPT gave me a HGH in th morning suggestion with Tesa at night?? Where did that come from?

It’s hard to imagine how that stack isn’t considerably inferior to either drug individually, the HGH is gonna step on the tesa pretty hard at the transitions. Don’t overcomplicate things.