I'm 55 should I take Tesamorelin or just go for hgh and trt?

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wulf00777 said:
I've read a lot of people stating Tesa didn't do anything for them. That's why with the price tag I'm looking for other ways to gain muscle and lose the last fat after I lose my majority of weight, just planning ahead.
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Well I'll chime in with an opposite statement then 🙂

Tesa 2mg + Ipa 300mcg every day for about 3 months did wonders for my mid section. I've lost almost all fat in the love handles area and the sides of the mid section, an area which used to be extremely stubborn during my previous attempts at weight loss.
 
foffspam111 said:
Thank you for the information. I am doing 2mg of Tesa daily on a 5x2 schedule. It is working great. I take it before bed after 3hrs of no food. I started with CJC/IPA but right away side effect, I switched to tesa after a month. No side effects, great sleep, muscle tone, energy, and fat burn have been great. I may try your schedule and see if there is any difference but probably won’t do CJC/IPA anytime soon though.
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Great feedback. I’m going to give Tesa a try here soon. I’m thinking of dropping my weekly Reta to 2mg or even 1mg a week and add the 2mg Tesa. Any side effects with the Tesa ? What’s the cycle for Tesa? 6-8 weeks? And I also will be following the 5x2 schedule.
 
Quatroskin said:
Great feedback. I’m going to give Tesa a try here soon. I’m thinking of dropping my weekly Reta to 2mg or even 1mg a week and add the 2mg Tesa. Any side effects with the Tesa ? What’s the cycle for Tesa? 6-8 weeks? And I also will be following the 5x2 schedule.
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I have been running a 5x2 weekly schedule and will for 90 days (I am in the last 2 weeks now) then take 2-4 weeks off. From there I may try Cjc/ipa again but it’s tough to not just run tesa again with the results I’ve gotten. Only side effects were some water retention the first 2 weeks but after that no. All positive so far.
 
Just in case others are interested, I thought I was being quite conservative with my HGH dose of 1.5iu/day. Finally got around to getting IGF-1 tested and result was 50 micromol/l mean 20 standard deviation 5 to 7 . ( at age 58 ), which is quite high , ( US units may be different ) more than 3 standard deviations above the mean. Unfortunately never got tested beforehand. Aim was any help I can get with keeping 54% weight off. Given I have some assymptomatic evidence of early cardiac failure on echo, overdoing it on HGH is probably not a good idea. Will be dropping the dose and getting retested. I did lose extra cm off my waist circumference from it.
 
lessthanhalf said:
Just in case others are interested, I thought I was being quite conservative with my HGH dose of 1.5iu/day. Finally got around to getting IGF-1 tested and result was 50 micromol/l mean 20 standard deviation 5 to 7 . ( at age 58 ), which is quite high , ( US units may be different ) more than 3 standard deviations above the mean. Unfortunately never got tested beforehand. Aim was any help I can get with keeping 54% weight off. Given I have some assymptomatic evidence of early cardiac failure on echo, overdoing it on HGH is probably not a good idea. Will be dropping the dose and getting retested. I did lose extra cm off my waist circumference from it.
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Be careful with test too if you are taking it.
 
lessthanhalf said:
Just in case others are interested, I thought I was being quite conservative with my HGH dose of 1.5iu/day. Finally got around to getting IGF-1 tested and result was 50 micromol/l mean 20 standard deviation 5 to 7 . ( at age 58 ), which is quite high , ( US units may be different ) more than 3 standard deviations above the mean. Unfortunately never got tested beforehand. Aim was any help I can get with keeping 54% weight off. Given I have some assymptomatic evidence of early cardiac failure on echo, overdoing it on HGH is probably not a good idea. Will be dropping the dose and getting retested. I did lose extra cm off my waist circumference from it.
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So an IGF-1 getting close to 400:

382.5 ng/mL
 
On medically prescribed testosterone gel at low doses, was 8 pretreatment now 13-16 nmol/l ref range 10-30 - total, so not high at all, at those doses there is no evidence of negative cardiovascular outcomes. Again units used in the states tend to be different. After checking with chatgpt the igf-1 level is more like 5 standard deviations above normal.
 
bogardbilla said:
Well I'll chime in with an opposite statement then 🙂

Tesa 2mg + Ipa 300mcg every day for about 3 months did wonders for my mid section. I've lost almost all fat in the love handles area and the sides of the mid section, an area which used to be extremely stubborn during my previous attempts at weight loss.
Click to expand...
Awesome, thanks for the feedback. That reinforces my plans to use Tesa and ipa for fine tuning.
 
lessthanhalf said:
On medically prescribed testosterone gel at low doses, was 8 pretreatment now 13-16 nmol/l ref range 10-30 - total, so not high at all, at those doses there is no evidence of negative cardiovascular outcomes. Again units used in the states tend to be different. After checking with chatgpt the igf-1 level is more like 5 standard deviations above normal.
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I guess you will be checking the velocity of any expected PSA increase.
 
I had blood tests done last week and requested the PSA not be tested, but it was anyway and was a tiny bit high. From a quick look at the research I do not see a lot of advantage in screening for prostate cancer, given it does not improve long term outcomes much for a whole lot of investigations and treatment. I do not think I will be able to convince my GP or endocrinologist not to test it anyway, and still prescribe testosterone. Not really interested in the slippery slope of a few more tests and then a biopsy or MRI when most cancers found are not going to do anything much.
 
Researcher6076 said:
I am 71, gym rat, scientist, yoga teacher, lol. I alternate days of 2mg Tesa fasting in the mornings, with 200mcg Ipamorelin + 200mcg CJC-1295 NODAC fasted before bed. And one day a week off. It's more conservative than all Tesa, so no side effects. And cheaper. And mechanisticly Tesa 3 days at 2mg is more effective than 6 days are 1mg. The ipamorelin + CJC-1295 NODAC is giving me the flushing tingles, so it is probably doing a little
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How is your sleep on this protocol and how was your sleep before you commenced?
 
bogardbilla said:
No side effects for me, except maybe better sleep. There's no cycle for Tesamorelin, you're supposed to take 2mg every day until you reach your desired goal.
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Just an FYI , prescription tesa (brand name Egrifta) has a prescribed run time of 6 months, 2 mg 5&2. Target demographic HIV patients with diagnosed excessive visceral fat.
 
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Here is a great example of a panel to specifically request. This is in addition to a bunch of all the standard stuff ie... Hematocrit, hba1c, fasted glucose, glomerular filtration etc...
 
lessthanhalf said:
From a quick look at the research I do not see a lot of advantage in screening for prostate cancer, given it does not improve long term outcomes much for a whole lot of investigations and treatment.
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But PSA is commonly checked on TRT since it can elevate PSA. TRT with HGH can be like Miracle-Grow for the prostate:

https://academic.oup.com/jcem/article-abstract/88/1/88/2846008

quoted said:
The percentage increase in prostate volume was greater in hypoandrogenemic patients receiving both GH and testosterone replacement (51 ± 11%) than in those receiving GH replacement alone (15 ± 3%; P
[archived internal link]
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Aussiegreenmachine said:
How is your sleep on this protocol and how was your sleep before you commenced?
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My sleep is better, but I'm doing other thing so I cannot attribute sleep improvementsto this.
 
I am a huge fan of tesa/ipa. I'm currently on TRT, Reta, and Tesa/ipa and it has been a life changer! Lost 100 lbs of fat and gained 10lbs of lean muscle. My Igf-1 went from approx 150 up to 300. Not quite super-physiological level, but pretty high for a 42 year old. The reta is easily able to overcome the insulin resistance from the tesa/ipa. My fasted glucose is always in the low 80's and I have even tried to see if I can spike it with donuts but the highest I have been able to get it was 105. And my visceral fat levels went from a 19 on the index to a 6 over the last year while bringing my ALT and AST levels into the normal range. The only thing left on my blood work that is a problem is my HDL is a little low. I am taking 2mg tesa and 250mcg ipa fasted before bed 7 days a week. As an added bonus it gives me great sleep and recovery. I do 12week on, 4 week off and I hate doing my off cycle, but I worry about receptor downregulation so I suck it up and do it anyway.
 
Tbagger said:
I am a huge fan of tesa/ipa. I'm currently on TRT, Reta, and Tesa/ipa and it has been a life changer! Lost 100 lbs of fat and gained 10lbs of lean muscle. My Igf-1 went from approx 150 up to 300. Not quite super-physiological level, but pretty high for a 42 year old. The reta is easily able to overcome the insulin resistance from the tesa/ipa. My fasted glucose is always in the low 80's and I have even tried to see if I can spike it with donuts but the highest I have been able to get it was 105. And my visceral fat levels went from a 19 on the index to a 6 over the last year while bringing my ALT and AST levels into the normal range. The only thing left on my blood work that is a problem is my HDL is a little low. I am taking 2mg tesa and 250mcg ipa fasted before bed 7 days a week. As an added bonus it gives me great sleep and recovery. I do 12week on, 4 week off and I hate doing my off cycle, but I worry about receptor downregulation so I suck it up and do it anyway.
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You can reset receptors using the Mon-Fri tesa 2 mg protocol, take the weekends off. Do that for 26 weeks. Added bonus, easy math. 10 mg vial lasts one week, 20 mg vial - two weeks.
 
latviantower said:
You can reset receptors using the Mon-Fri tesa 2 mg protocol, take the weekends off. Do that for 26 weeks. Added bonus, easy math. 10 mg vial lasts one week, 20 mg vial - two weeks.
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That's what some people say, but there has been no studies done on it. The general consensus has been that it was either the wellness clinics that started the 5 on 2 off protocol because they are closed on weekends, or people started doing it to save some money. Either way, I don't think it's enough time to prevent downregulation so I give it 4 weeks off. My results are showing that it's working, so I'm gonna stick to it. But the trials and prescription protocol for Egrifta is daily injections for up to a year without any breaks. So I might just be overly cautious about it.
 
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