Igf1 lr3

[205070]

Hi, looking for honest feedback on IGF-1 LR3.

• What were your results and how did you feel on it?

• What did you stack it with?

• Any issues with hypoglycemia?

I'm currently on Ostarine, Cardarine, and Retatrutide.

Thanks!

 

[joseblo]

I'm interested as well. Looking for tested (or otherwise trusted) sources.

I assume there's always Uther or AA?

 

[Waclive]

Ryan Humiston said he tried it a few times and the only time he seen a benefit from it was when it come from a compounding pharmacy already reconstituted sent in a cooler, like you would get from Ways2well.

 

[joseblo]

Ryan Humiston said he tried it a few times and the only time he seen a benefit from it was when it come from a compounding pharmacy already reconstituted sent in a cooler, like you would get from Ways2well.

There definitely seems to be some disagreement on whether AA (0.6% or 0.06%) is needed for recon or if BAC is fine. Presumably, the question is about degradation, but if vials are basically single use at 0.1mg or even 1mg that doesn't seem like a huge loss.

I'm more interested in the potential effects on Lp(a) cholesterol than getting swol. Certainly, if the the half-life is as long as claimed 24hrs, subq seems perfectly adequate. I have to wonder if vendors just ship junk or the more controlled stuff instead, but I know nothing of it, other than the rarity of any testing.

 

[Calm Logic]

It can be quite an inconvenience regarding administrstion. Some "bros" insist on bilateral injections into muscle on a daily basis or whatever:

https://thinksteroids.com/steroid-profiles/igf-1/

 

[Waclive]

The IGF-1 LR3 half life is like 10-30 minutes though.

 

[205070]

I'm interested as well. Looking for tested (or otherwise trusted) sources.

I assume there's always Uther or AA?

I ordered a kit from a source on the forum. I will provide an update when I receive it.

 

[swimmer]

I started using it 4 weeks ago. 40 mg per day alternating bilateral IM and subq. For bilateral I read you should administer less than 10 min after working the target muscle group. At the gym I disappear into the restroom for 5 min and then return to finish my workout. Once I hit a small blood vessel and it left a weird looking half dollar sized bruise in the center of my bicep. It didn't go away for 10 days. I have not felt any hypoglycemia but I do carry sugar cookies in my gym bag now. Target muscles seem bigger but it might be imagined.

I reconstitute with .6% AA and right before injection I add 20 units of sterile water. I have never felt a burn from injection.

 

[205070]

I started using it 4 weeks ago. 40 mg per day alternating bilateral IM and subq. For bilateral I read you should administer less than 10 min after working the target muscle group. At the gym I disappear into the restroom for 5 min and then return to finish my workout. Once I hit a small blood vessel and it left a weird looking half dollar sized bruise in the center of my bicep. It didn't go away for 10 days. I have not felt any hypoglycemia but I do carry sugar cookies in my gym bag now. Target muscles seem bigger but it might be imagined.

I reconstitute with .6% AA and right before injection I add 20 units of sterile water. I have never felt a burn from injection.

Did you only give intramuscular injections in your arms? And did you bring a pre-filled syringe with your dose to the gym? I have heard that subcutaneous injections are best for maintaining a good balance in muscle development.

 

[Calm Logic]

I started using it 4 weeks ago. 40 mg per day alternating bilateral IM and subq. For bilateral I read you should administer less than 10 min after working the target muscle group. At the gym I disappear into the restroom for 5 min and then return to finish my workout. Once I hit a small blood vessel and it left a weird looking half dollar sized bruise in the center of my bicep. It didn't go away for 10 days. I have not felt any hypoglycemia but I do carry sugar cookies in my gym bag now. Target muscles seem bigger but it might be imagined.

I reconstitute with .6% AA and right before injection I add 20 units of sterile water. I have never felt a burn from injection.

First the 5 grams of enclo and now this. A bro among bros, haha.

 

[swimmer]

Did you only give intramuscular injections in your arms? And did you bring a pre-filled syringe with your dose to the gym? I have heard that subcutaneous injections are best for maintaining a good balance in muscle development.

I have a little portable peptide cooler I use for traveling I put in the gym bag. I bring the reconstituted vial of lr3, a syringe and a vial of sterile H20. I draw 40mg lr3 then 20 units H20. I inject 20 mg into each side. I have only done biceps and delts so far. On days I don't go to the gym I do subq. How do you like Ostarine and Carderine? I have both but have not tried them yet. I'm excited about carderine helping my swim times.

 

[joseblo]

I ordered a kit from a source on the forum. I will provide an update when I receive it.

Feelz can be valid, but I'll say again, people seem to have really different experiences. Did the vendor provide a COA? Any 3P COAs?

Thanks!

 

[joseblo]

The IGF-1 LR3 half life is like 10-30 minutes though.

I think that's the unmodified IGF-1. Everything I"ve read indicates it's got about a day of half-life, which makes subq (though I'd still localize it) more reasonable.

https://pep-pedia.org/peptides/igf-1-lr3

If you're seeing something different out there, please post the link!

 

[205070]

I have a little portable peptide cooler I use for traveling I put in the gym bag. I bring the reconstituted vial of lr3, a syringe and a vial of sterile H20. I draw 40mg lr3 then 20 units H20. I inject 20 mg into each side. I have only done biceps and delts so far. On days I don't go to the gym I do subq. How do you like Ostarine and Carderine? I have both but have not tried them yet. I'm excited about carderine helping my swim times.

Cardarine really changes the game when it comes to cardio. You feel like you have unlimited stamina and you don't feel like time is passing. With ostarine, I haven't noticed much difference in my athletic performance, no significant increase in strength or muscle pump, but I think that's due to my large calorie deficit and low carbohydrate intake. To be honest, I mainly use it for its anti-catabolic properties. I take 20 mg of ostarine and 10 mg of cardarine before cardio.

 

[205070]

Feelz can be valid, but I'll say again, people seem to have really different experiences. Did the vendor provide a COA? Any 3P COAs?

Thanks!

I couldn't find a seller who supplied a Janoshik test. I bought a kit from the seller Cassie MKM on the forum because I saw that he had a pretty good reputation and, above all, the price was reasonable. I'll give feedback when I receive it.

 

[Waclive]

I think that's the unmodified IGF-1. Everything I"ve read indicates it's got about a day of half-life, which makes subq (though I'd still localize it) more reasonable.

https://pep-pedia.org/peptides/igf-1-lr3

If you're seeing something different out there, please post the link!

Bro science

View: https://youtu.be/Cu9PVWM2fJo?si=VNlNS6uJgDA8xZOD

 

[joseblo]

Bro science

View: https://youtu.be/Cu9PVWM2fJo?si=VNlNS6uJgDA8xZOD

Thanks! It's hilarious that even people in the comments can't agree, when they think they're agreeing with him. It's interesting that he complains about getting garbage, but doesn't just send his own vial to Janoshik from one of the more reputable sources for $300. The prices are as usual 10x for the vial vendors.

View: https://youtu.be/Cu9PVWM2fJo?t=192

All the medical commentary I've seen suggests it has the longer half-life rather than 10min Ryan claims because,

"...they added a 13 amino acid tail to the end terminus, hence long. And replaced the glutamic acid that was in the third position with arginine, giving you R3... What's fascinating about this is normally additions to the molecule extends its half-life...Those changes to the peptide reduce its affinity for binding proteins by roughly three orders of magnitude... LR3 rarely ever binds to binary proteins. So, it's definitely not going to make it to the ternary complex step. It's not going to last anywhere from 12 to 24 hours."

Journal of Pathology says,

"To determine the effect of continuous administration of Long R3 IGF-1 [an IGF-1 analog with an extended N-terminal tail and Arg for Glu substation at position 3, leading to a prolonged half-life (20 to 30 hours) due to decreased binding to IGF binding proteins] on early atherogenesis or advanced atherosclerotic lesions... During treatment, plasma Long R3 IGF-1 levels were measured by a human ELISA kit (Gropep). Plasma total cholesterol levels were measured spectrophotometrically using enzymatic procedures, and triglyceride levels were quantified using a commercially available kit (Roche Diagnostics)."

IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype - PMC

Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, we studied the effects of the ...

pmc.ncbi.nlm.nih.gov

Not sure it really matters since bilateral isn't that much more of a pain in any case. Now if bio-availability or degradation in BAC was <5min that would really push to AA reconstitution.

 

[Waclive]

Thanks! It's hilarious that even people in the comments can't agree, when they think they're agreeing with him. It's interesting that he complains about getting garbage, but doesn't just send his own vial to Janoshik from one of the more reputable sources for $300. The prices are as usual 10x for the vial vendors.

View: https://youtu.be/Cu9PVWM2fJo?t=192

All the medical commentary I've seen suggests it has the longer half-life rather than 10min Ryan claims because,

"...they added a 13 amino acid tail to the end terminus, hence long. And replaced the glutamic acid that was in the third position with arginine, giving you R3... What's fascinating about this is normally additions to the molecule extends its half-life...Those changes to the peptide reduce its affinity for binding proteins by roughly three orders of magnitude... LR3 rarely ever binds to binary proteins. So, it's definitely not going to make it to the ternary complex step. It's not going to last anywhere from 12 to 24 hours."

Journal of Pathology says,

"To determine the effect of continuous administration of Long R3 IGF-1 [an IGF-1 analog with an extended N-terminal tail and Arg for Glu substation at position 3, leading to a prolonged half-life (20 to 30 hours) due to decreased binding to IGF binding proteins] on early atherogenesis or advanced atherosclerotic lesions... During treatment, plasma Long R3 IGF-1 levels were measured by a human ELISA kit (Gropep). Plasma total cholesterol levels were measured spectrophotometrically using enzymatic procedures, and triglyceride levels were quantified using a commercially available kit (Roche Diagnostics)."

IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype - PMC

Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, we studied the effects of the ...

pmc.ncbi.nlm.nih.gov

Not sure it really matters since bilateral isn't that much more of a pain in any case. Now if bio-availability or degradation in BAC was