I am a food scientist specializing in gut health and fibers. AMA.

[lessthanhalf]

what are you exactly trying to achieve? Alluloe is not considered fiber.

Allulose is actually fairly interesting. Another sugar substitute, definitely not fibre. Ever since seeing several papers showing erythritol was associated with increased risks of stroke and bbb damage ) not proven but suggestive, I needed to find an alternative and nearly everything in the shops has erythritol in it.

Allulose does not raise blood sugar and has been shown in more than one rodent study to reduce weight even at fairly small intakes , sadly no human studies on weight, but the animal studies are definitely good enough to justify them. And I cannot find any studies showing negative effects.

The way food additives are regulated is weird, once they get approved as " generally regarded as safe" it takes a lot of evidence for them to get taken off the market. So by far the most commonly used artificial sweetener ( or at least bulk agent in them ) is at best of doubtful safety, and there is some evidence erythritol, which is also naturally produced by the body is associated with increased cardiovascular risk.

 

[collioureviews]

Insoluble fibers such as green bananas and viscous fibers like oat beta glucans can improve your stools by bulking and increasing stool moisture. They are also good for gut bacteria in general.

I could've sworn you just wanted to see the world burn by recommending green bananas.

Then I read the whole thread...

 

[YoYoFat]

I believe that there is a lot more to the gut on overall health, including mental health.

Not the OP, but anyone who’s ever walked into Barnes & Noble knows that a lot of our gut motility is in our head.

 

[ghreid]

what are you exactly trying to achieve? Alluloe is not considered fiber.

sorry for the confusion. actually wanted your opinion on FOS fiber and gut health, not the sugar substitue. Is it worth the $. was going to use psyllium but interfers with the absorption of too many of my meds. thanks

 

[lastresort]

We (me and other colleagues) did a brief internal review of FOS, and we found that FOS (not to be confused with naturally derived inulin, which is much longer than FOS) improved stool quality but doesnt noticeably improve metabolic markers, if at all. It does promote bifidobacteria, which is crucial for general gut health and immune system, though.

You can diversify your fiber choices with fleshy fruit like apples.

 

[lastresort]

Have you touched the topic of Akkermansia in your work?

My colleague did. It is one of gut bacteria that has been receiving quite a spotlight because of its strong inverse correlational relationship with obesity.

 

[Enyola]

Some people in a brand-glp1-forum experimented with it a while ago, in the hope of increaseing natural glp1 levels before/while/after weaning off from mounjaro. They even imported living Akk. from the US (maybe unnecessarily ), because here you could (/can?) only get pasteurized ones.

AI pointed me to this recent short term study: Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial

Are you or you colleague aware of longer trials in the making or already published, including a washout phase to see what happens afterwards?

 

[lastresort]

Some people in a brand-glp1-forum experimented with it a while ago, in the hope of increaseing natural glp1 levels before/while/after weaning off from mounjaro. They even imported living Akk. from the US (maybe unnecessarily ), because here you could (/can?) only get pasteurized ones.

AI pointed me to this recent short term study: Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial

Are you or you colleague aware of longer trials in the making or already published, including a washout phase to see what happens afterwards?

Anaerobic bacteria including Akkermansia municipilia are difficult to cultivate and much more difficult to commercialize as probiotics because they will die as soon as they are exposed to oxygen. That's probably why it had to be imported.

There are a few clinical studies out there that found apple pectin and green banana promote Akkermanisa muciniphilia, but not necessarily related to weight management or including washout phases.

Apple pectin enriched smoothie and gut bacteria

Green banana flour promote diverse gut bacteria

 

[Shittersfull]

Leaky gut syndrome is a real thing, but much more so in a research context than as a reliable useful clinical diagnosis, with effective treatments. Doctors are generally not going to diagnose it often, as there really are no consistent reliable tests for it or treatments for it that have been proven to work.

It is a lot more likely in the context of chronic gut problems like inflammatory bowel disease or irritable bowel syndrome, especially the diarrhoea type. So if your gut functions well and does not hurt it is less likely. The are hundreds of studies of various pro, pre and post biotics that can help, but all the studies are in general small and not close to gold standard evidence, same goes for fiber supplements. What is generally regarded as a healthy diet, or a healthy diet for the gut is likely to help, so mediterranean diet, mostly plants and not too much food overall, enough but not extremes of fiber, some fibers or resistant starches might be better than others but none are really well proven , and depending on the individual some can cause adverse effects like pain bloating or diarrhoea, especially in the context of ibs.

Almost certainly a bunch of weird gut bug , endotoxin and food chemicals leaking into your bloodstream are going to increase inflammation, and there is evidence it can contribute to auto immune disorders, what is much less proven is can it be easily diagnosed or treated in a reliable consistent way.

Before I lost weight at 145 kg, I had ulcerative colitis supposedly in remission on treatment, but with chronic daily diarrhoea, and chronic daily gut pain for over a decade. Not sure what crp was then but ESR was 44 which is fairly high in the absence of a definite cause. I have zero doubt I had leaky gut then, and that may well have contributed to developing coronary artery disease and early heart failure as well as made me feel pretty crappy in general. But that is a fairly extreme example, it would be much harder to say for sure if someone really has it going on in less extreme circumstances. With massive weight loss and a much better diet inflammatory markers and gut symptoms are much better, so I assume it is gone now.

In general a healthy diet and adequate fiber is all you can really do, maybe probiotics?

Have you ever considered oral versions of kpv and/or bpc 157 for your gut issues?

 

[lastresort]

Have you ever considered oral versions of kpv and/or bpc 157 for your gut issues?

I do'nt have one I think so I have not taken it. BPC157 seems interesting since it directly affects zonulin and claudin, two important tight junction proteins in gut lining.

 

[Shittersfull]

I do'nt have one I think so I have not taken it. BPC157 seems interesting since it directly affects zonulin and claudin, two important tight junction proteins in gut lining.

I'm no expert on anything, but bpc 157 is great for healing and kpv is great for anti-inflamitory. There's a lot of people on this forum That swear by these peptides when injected. I have read that these peptides both survive the stomach acid and digestion process quit well. If I had the issues, you have. Would try them. Tomarrow I will be at work, I can look then for a article I found on this subject, and send it your way.

 

[Skidude]

Ehh...sorta. Its very unpleasant to eat raw banana. Cooking it makes it rather defeats the purpose. Trust me, just buy the green banana flour from amazon.

Try this :

I would recommend kefir since it has a lot more diverse lactic acid bacteria and yeast.

I am on week one of 8oz per day of Kefir, it is not bad tasting

Thanks for the suggestion

 

[lastresort]

Thanks for your reply. I’m curious, though — what does this have to do with the thyroid? Also, I can confirm she barely exercises in her daily life.

Thyroid hormones directly affect activity of sodium-potassium pumps, which are crucial parts of cell energy (adenosine triphosphate) generation

 

[lastresort]

Allulose is actually fairly interesting. Another sugar substitute, definitely not fibre. Ever since seeing several papers showing erythritol was associated with increased risks of stroke and bbb damage ) not proven but suggestive, I needed to find an alternative and nearly everything in the shops has erythritol in it.

Allulose does not raise blood sugar and has been shown in more than one rodent study to reduce weight even at fairly small intakes , sadly no human studies on weight, but the animal studies are definitely good enough to justify them. And I cannot find any studies showing negative effects.

The way food additives are regulated is weird, once they get approved as " generally regarded as safe" it takes a lot of evidence for them to get taken off the market. So by far the most commonly used artificial sweetener ( or at least bulk agent in them ) is at best of doubtful safety, and there is some evidence erythritol, which is also naturally produced by the body is associated with increased cardiovascular risk.

Did you know it was a Korean company (my homeland!) that lobbied it hard for it to be excluded from the added sugar label?