Hypotension with tirzepatide or retatrutide

[olehandro]

hypotension with tirzepatide and retatrutide. 100/50

This has been going on for 6 months after starting GLP

Has anyone had this side effect?

 

[PatchyFog]

I get it a bit with just straight Tirz, but I figured that's because I lost a lot of weight and the doc hasn't titrated down my BP meds enough yet.

 

[Glenn]

I quit taking my high blood pressure medication about a year ago, but my BP continues to drop. My average is around 90/45. I do resistance and cardio training six days a week and currently staking tirz 10mg and reta 2mg weekly.

 

[latviantower]

I get it a bit with just straight Tirz, but I figured that's because I lost a lot of weight and the doc hasn't titrated down my BP meds enough yet.

I was on 4 different BP agents when I started tirz. I couldn’t wait for my doc to make decisions and you need to think about your options as well from what you describe. I weaned myself off everything, checking my BP 3-4 times a day and adjusting to keep it in the 110-120/60-70 range as my weight decreased. I only saw my doc once every six months and updated her each time. It’s been six months without any meds now and I’ve leveled off at 105/70, sometimes right after a workout it’s 100/55. I also added back salt, which I had been told to avoid for the last 30 years. (!)

As the saying goes - Physician, heal thyself.

 

[geoguy78]

hypotension with tirzepatide and retatrutide. 100/50

This has been going on for 6 months after starting GLP

Has anyone had this side effect?

I think it's a side effect of losing a lot of weight quickly. I was dizzy a lot for a year. It's settled down now.

 

[lessthanhalf]

I had hypertension when I started at 145 kg and was on one medication. As I lost weight it was obvious that my blood pressure was dropping as it would start to go black when I stood up. So I checked bp and stopped medication once it was below 120/80. After more weight loss mine has stayed around 105-110/60-65 for the past 2 years at 67-75 kg. The postural hypotension is still there, so I need to be slightly careful if my vision starts disappearing after standing up. The only real research I could find on blood pressure changes with weight loss was that postural hypotension and lowered blood pressure was very common after weight loss surgery and does not necessarily get better. Mostly due to all the blood vessels in your gut no longer having any back pressure on them from the fat / intra abdominal pressure.

Losing weight reduces blood pressure and GLP medications reduce it as well.

At that BP a medical checkup would be sensible , but it would only require doing anything about it if you were getting problems like dizzyness on standing or falling over from it. There are things that can be done if it is causing problems, otherwise it is not harmful.

 

[tendency]

hypotension with tirzepatide and retatrutide. 100/50

This has been going on for 6 months after starting GLP

Has anyone had this side effect?

damn i wish i had that side!

 

[cldfront]

First four months I had to be very careful standing up because I'd get swoony. That has resolved itself for me.

 

[Boscough]

hypotension with tirzepatide and retatrutide. 100/50

This has been going on for 6 months after starting GLP

Has anyone had this side effect?

Not sure if this aligns with what you’re asking about. I was microdosing a compounded Tirz for about 10 wks. Worked great. Food noise was silenced. Then I switched to grey Tirz and tried .5mg twice and wasn’t really feeling a difference. Upped dose to a full 1mg and 1 day later felt and saw my blood pressure jump to hypertensive range (also had headaches too but not sure it was 100% related). I’m now at 6 days out from the 1mg dose and things have calmed down considerably. I’ve read this is not that uncommon and is often part of the acclimation to Tirz. I also think I’m uber sensitive to Tirz as even the microdose seemed to work well for me.

 

[latviantower]

I had hypertension when I started at 145 kg and was on one medication. As I lost weight it was obvious that my blood pressure was dropping as it would start to go black when I stood up. So I checked bp and stopped medication once it was below 120/80. After more weight loss mine has stayed around 105-110/60-65 for the past 2 years at 67-75 kg. The postural hypotension is still there, so I need to be slightly careful if my vision starts disappearing after standing up. The only real research I could find on blood pressure changes with weight loss was that postural hypotension and lowered blood pressure was very common after weight loss surgery and does not necessarily get better. Mostly due to all the blood vessels in your gut no longer having any back pressure on them from the fat / intra abdominal pressure.

Losing weight reduces blood pressure and GLP medications reduce it as well.

At that BP a medical checkup would be sensible , but it would only require doing anything about it if you were getting problems like dizzyness on standing or falling over from it. There are things that can be done if it is causing problems, otherwise it is not harmful.

“Postural” hypotension. So much more descriptive than the American “orthostatic” hypotension. And so much more scientific than my old stand by - “I passes out when I stands up too quick.”

I shall use “postural” henceforth.