How soon did you start feeling effects after first dose?

[lil ghost]

idk if it's a placebo effect or if I'm just a quick responder, but I'm already feeling a complete lack of appetite less than 24 hours after my first pin of tirz. I even started on a low dose (2mg) since I'm on the lower end of the "healthy" BMI range. I could be deluding myself into thinking that I'm not hungry, but it legitimately feels like I'm full despite not eating much today.

This is the very first time I've tried any kind of peptide, so I don't have any personal reference points to compare with my current experience. I'm just curious if anyone else has felt effects kick in right away or if I'm delusional and/or an anomaly.

 

[woundcarping]

That’s fairly normal timing. I model Tmax as 24 hours.

I remember looking for the same info when I first started, curious if it was placebo or if I was actually already on the ride maybe 12 hours in.

 

[Beardboost]

I reacted rather quick to Reta, considering I was in a bad mindset before my first injection thinking nothing would work, next day I was locked in, eating healthy, keeping to the same diet I am currently with no temptations for sugar, my dad on the other hand took 2-3 weeks for the food noise to disappear, strange how we all act so different even from the same vial

 

[J Arbey]

My being able to tell starts approximately 24 hrs after a dose and peaks by 48 hrs after a dose.

 

[cloratheshadow]

I feel it very fast. Within an hour or two. It will be more intense if you do it in your stomach. You should really feel it the next day but once it starts building you’ll feel it all the time even when you need to dose usually

 

[TinyPCOSgirl]

My entire body was sore the following day. After my first dose, I never felt side effects

 

[leeann82]

Within 3-4 hours.

 

[bbbilly]

With tirz, I can set a clock to the explosive diarrhea and projectile vomiting at the 36 hour mark after a first dose after a break, or upping my dose. but i do start feeling the suppression by the time i wake up (i take my shot right before bed)

 

[lessthanhalf]

I keep seeing posts from people starting GLP's on low doses who are not very overweight, who seem to get quick or significant responses on low doses. It make me wonder if it is more likely to do this in those who are less overweight, than those who have more weight to lose and presumably more severe metabolic and hormonal abnormalities - more insulin and leptin resistance etc. After losing 70kg and having side effects from low dose ozempic , I managed to crank the dose of tirzepatide to 15mg over a month and was still a bit hungry. ( using small frequent doses to reduce risks of catastrophic side effects )

 

[anhydrous]

For me onset around the 3 hour mark.

 

[Ruckus4519]

I keep seeing posts from people starting GLP's on low doses who are not very overweight, who seem to get quick or significant responses on low doses. It make me wonder if it is more likely to do this in those who are less overweight, than those who have more weight to lose and presumably more severe metabolic and hormonal abnormalities - more insulin and leptin resistance etc. After losing 70kg and having side effects from low dose ozempic , I managed to crank the dose of tirzepatide to 15mg over a month and was still a bit hungry. ( using small frequent doses to reduce risks of catastrophic side effects )

Thanks for sharing LTH. I’ve been disappointed I wasn’t getting the same wondrous Miracle Drug Experience ™. I’m early in the schedule, but I haven’t felt shit. Same appetite and everything

 

[thenbhds]

day after, i felt like every piece of food was descending in a huge lump LMFAO. i felt fuller quicker. i didn’t care about food as much. it was great!!! i have crazy food noise normally

 

[oldjarhead]

I felt it the next day. I was on lunch break at work. I could only eat half of my lunch because I was full. I do remember being a little weirdly disappointed, somewhat confused, too. I have been over eating all these years and figured that maybe this how normal people eat. I'm used to small meals now after 3.5 months. Sometimes I have to force some meals to get my protein in for that day. Don't be in a rush to increase dosage...my opinion.

 

[lessthanhalf]

When I started Ozempic about a year after losing about 70kg, that was the first thing I noticed, feeling too full to finish eating a fairly small amount of food, not sure I had ever actually experienced that before then.

 

[Danger1212]

idk if it's a placebo effect or if I'm just a quick responder, but I'm already feeling a complete lack of appetite less than 24 hours after my first pin of tirz. I even started on a low dose (2mg) since I'm on the lower end of the "healthy" BMI range. I could be deluding myself into thinking that I'm not hungry, but it legitimately feels like I'm full despite not eating much today.

This is the very first time I've tried any kind of peptide, so I don't have any personal reference points to compare with my current experience. I'm just curious if anyone else has felt effects kick in right away or if I'm delusional and/or an anomaly.

Pinned my first 2mg dose of R. At first…nothing. Thought it might be bunk.

By days 2–3 though, I started noticing a shift. Not really hungry, not really full, just… neutral. Eating felt controlled, like I could stop when I actually needed to.

Then the next two mornings I woke up around 4am with headaches (never happens to me), even though I was hydrated and on top of electrolytes.

So yeah, seems like it is working… just not how I expected

Appreciate posts like this; helpful to hear what others experience early on.

Good luck!

Danger1212

 

[clemochi]

I started on a low dose for the very first time last week and literally almost immediately, like within a half hour, I felt the effects. It was like a fog (of constant food noise!!) suddenly cleared. The rest of the day I found sticking to my calorie deficit stupidly easy.. I later grabbed a pre-planned snack and forgot to finish it halfway through. That NEVER happens. Then had a take it or leave it attitude about dinner later. Is this how effortlessly thin people go through life!? Amazing stuff.

Alas with the low starting dose, the food noise and genuine actual hunger started ramping back up after a few days. I'm really looking forward to eventually titrating up to whatever dose will work throughout the whole week.

 

[FlowerFairy]

I feel it very fast. Within an hour or two. It will be more intense if you do it in your stomach. You should really feel it the next day but once it starts building you’ll feel it all the time even when you need to dose usually

I don’t pin in my stomach. It hurts more and I prefer less pain. I pin in my outer thighs and feel it just as quickly as when I pinned in my stomach. And I’m more comfortable.

 

[hoobz]

After the first shot I could swear it was instant for me, I was 1.5 hr before usual breakfast time when I had the shot and I ate breaffast only after 3 hrs just because it was already 11 AM, I wasn't hungry.

After the second shot it was not until the 2nd day that I felt full effect.

3rd shot coming this Wednesday, we'll see.

 

[msyntakz]

I have only been on the 2.5mg dose for the past month. I pin midday and feel it by late afternoon early evening, enough to reduce hunger signaling. But by the next day/morning, that's when it's always the most noticeable. So yeah, from the first few hours through the first 24 hours is when I have always most noticed it. And as others have mentioned, it only increases as it compounds with subsequent doses.

 

[Sasquatch]

I started over a year ago with 2.5mg. I could feel it within minutes. Yes, it's a weird feeling, if you've thought about food for 60 years. At the current 19.5mg, it comes on a little slower. One of the first @ 15mg, I caught a little buzz. I still don't know what happened?