Higher dose for higher weight

[woundcarping]

You may not be getting the glucagon agonism intensity at that low of a dose of reta. I am at 8 mgs but am considering some added triz or sema for hunger. Reta doesnt seem to curb my hunger that well but im still slowly losing fat. Maybe look into flip flopping your triz and reta stack.

GCGR is dose dependent, as best I can tell. My theory is/was/has been to titrate Reta as quickly as sides allow, otherwise it might as well be taking Tirz if not for the GCGR... this is assuming the goal is losing the big'n status.

 

[rettta]

GCGR is dose dependent, as best I can tell. My theory is/was/has been to titrate Reta as quickly as sides allow, otherwise it might as well be taking Tirz if not for the GCGR... this is assuming the goal is losing the big'n status.

100% agree, thats my thought process as well. I am obviously no dr, just some random internet poster but I feel like the poster is probably just wasting/getting no effect from the reta.

 

[BNLFL]

Big un is hilarious I can’t help it I’m like a dog — food motivated

Married with Children Al Bundy deal, only he was referring to big TaTa's.

 

[FarmgirlRebel]

Im definitely very dialed in with nutrition. Lowish carb, Whole Foods, no liquid calories, around 1700 cals a day (2300 is maintainance) tons of lean protein. I am still losing a tiny amount but it’s been really hard to maintain a calorie deficit. I feel like the Tirz wears off completely after a couple days and I’m back to tons of food noise and hunger.

I don't know enough about you to really advise.

But I will say, 1700 cals a day would definitely be too high for me to lose any significant amount per week, regardless of quality of food. I've been shooting for 1200 cals a day and high protein content and haven't hit a stall yet. I'll freely admit though, the food noise is almost none existent for me on 5mg Tirz. so there are some days I don't hit my target of 1200 calories.

I recently added 1mg of Reta mid week as my goal is to up Reta for maintenance, and drop Tirz to a microdose.

65lbs lost, 61 yr old female, Tirz since Dec 1st.

 

[cloratheshadow]

I don't know enough about you to really advise.

But I will say, 1700 cals a day would definitely be too high for me to lose any significant amount per week, regardless of quality of food. I've been shooting for 1200 cals a day and high protein content and haven't hit a stall yet. I'll freely admit though, the food noise is almost none existent for me on 5mg Tirz. so there are some days I don't hit my target of 1200 calories.

I recently added 1mg of Reta mid week as my goal is to up Reta for maintenance, and drop Tirz to a microdose.

65lbs lost, 61 yr old female, Tirz since Dec 1st.

I weigh 260 so 1200 is extremely low for me. I do not want to lose muscle if I can help it. If I ate 1200 a day that would be over 1000 calorie deficit for me but congrats on that weight loss dude!!

 

[Neptide]

Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.

Week 7 is still early in the journey. I had to remember that Glp-1s aren’t magic pills but more like aids to support lifestyle changes. After going to 7.5 at week 9 I experienced more weight loss.

 

[lessthanhalf]

Given you are trying to lose 60+75 lbs , you are almost certainly going to need to eventually up the doses to standard maximum doses of 15mg tirz or what ever the equivalent is if mixing it with reta, or even possibly higher if that does not get you to your goal, it does not mean you need to rush to get there. The main reason to not increase doses is side effects, I have not seen you say you are getting any. And the fact that you are hungry is a strong indicator that the dose you are on is not causing a lot of gastrointestinal side effects and you can increase doses with low risks of side effects. Trying to achieve massive weight loss on low doses is not realistic in most cases.

The only other thing you need to consider is that you have already lost 60 lbs, this does make a lot of difference to how you might respond to the medication , and to energy expenditure . That degree of weight loss will be enough to reduce energy expenditure a fair bit, and increase hunger ,so you current doses may just be enough to keep you at a new lower weight but not enough to keep losing weight. Would really need to know age , height , activity levels and how long you have been losing weight for to make any guesses as to how much of an effect this might have. But if the calculations on your current calorie deficit were based on your start weight , you might find they are no longer accurate. I know my energy expenditure dropped by half from 145kg to 75kg, and weight loss dropped from 6kg per month to 0 kg per month on exactly the same calorie input.

 

[hoobz]

Seems like every piece of information that comes from a podcast, content creator, or blog is false. Everybody is cashing in on the GLP craze trying to get clicks. Everybody has an affiliate link. I'd bet money that doctor on that podcast is selling peptides and wellness supplements.

I know, I know. The only thing I trust is hard scientific evidence Need to do more research on this. I do realize that horse-sense is often far from reality, but I thought it was interesting and wanted to compare it to the actual experiences of ppl here.

 

[birdwhacker]

I know, I know. The only thing I trust is hard scientific evidence

I trust that least of all. Hard scientific evidence sent me to the hospital for a week after I got that second pfizer shot. No sir I will stick to circumstantial anecdote based evidence from overconfident forum goers.

 

[HereKittyKitty]

I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.

Sleep too. Sufficient sleep matters.

 

[BNLFL]

Sleep too. Sufficient sleep matters.

100% right on anything.

 

[hoobz]

I trust that least of all. Hard scientific evidence sent me to the hospital for a week after I got that second pfizer shot. No sir I will stick to circumstantial anecdote based evidence from overconfident forum goers.

I'm sorry to hear you ended up in hospital! Hope everything is ok for you now. For me the shot you mentioned worked really well. I like science because it separates emotions from facts and anecdotes from statistics. I realize it's not a perfect measure, but it's the best we seem to have. And one thing is teaches me is to never be overconfident.

 

[TeresaHip]

Also i still have decent slow stomach emptying but i am definitely HUNGRY. Also got a single vial of Cagri coming so I can try that also.

You don't hear much about cag here.

 

[derekd419]

Keep it simple, increase your Tirz.

Tirz primarily works by reducing consumption with less hunger and food noise. You’ve got plenty of runway left.

I'm a newb, but may I ask what food noise exactly means? I've seen it mentioned a few times while interacting on here

 

[deleted.user.16]

I'm a newb, but may I ask what food noise exactly means? I've seen it mentioned a few times while interacting on here

I think it means background hunger/cravings you get during non-meal-times when you don't want to be thinking about food?

 

[5byfive]

To me, its a constant drumbeat in the background of 'what can I eat' or 'when can I eat again'. Its thinking about what I'm going to eat for dinner while I'm eating lunch. It has nothing to do with hunger; its wanting to eat just to eat. Its not so much loud as it is persistent, just the thought of food always being there.

 

[CathyGoesFar]

I was splitting it but noticed better suppression every 5/6 days instead of 3! But adding a touch of Reta hopefully will help more

I noticed the same thing. Every 5 days is the sweet spot for me. Reta has a slightly longer half life though so be aware that it will reach a slightly higher steady state. It's not a big deal though. The trials start people at 2 mg. I just take it every 5 along with my tirz and expect I will move to 6 days once it starts taking over from the tirz more.

 

[usmccruchy]

Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.

from my experience.... when i hit a stall and i hear the hunger noise i give an extra 15 min of cardio and up the tirz. also i switch my diet when i stall. i already eat a pretty good diet. but i switch to salmon brown rice and broccoli for lunch and dinner all week. gets kinda nasty but for me it works.

 

[randompersonrandom]

Don't trust anything that doesn't come from some random guy on this forum speaking with absolute confidence.

That would make an EXCELLENT signature.

 

[derekd419]

I think it means background hunger/cravings you get during non-meal-times when you don't want to be thinking about food?

ahh okay okay, makes sense. I had this a lot in the first 3-4 months on tirz, but it's pretty much faded now