Hey over 50 ladies! Get in here, Let's talk

[amynurse]

Me! Me! I'm in the club, too!

51 and 18 months into GLP-1 usage. SW was 279, I'm 5'8" for reference. I'm now sitting at 158, with probably 10 pounds of extra skin....so I'm as close to goal as I'm probably going to get. I started on just tirz, then supplemented some maz, then switched to supplementing survo. I'm now just on tirz, at 10mg every 4 days (17-ish mg per week). I'm now focusing on building muscle and stamina. I will eventually have a tummy tuck, arm lift and leg lift. Not sure about "the girls" yet. They are almost non-existent

My best advice is to stay the course, get your protein and water in, expect hair loss and exhaustion....ride the wave...it's amazing on the other side!!

Oh! I forgot to mention the KLOW! Been taking each individual pep to equal KLOW (substitute GHK Basic for CU) for a year, along with selank, and epitalon twice a year. My skin has never looked better!

 

[FarmgirlRebel]

Hi All!

Love reading everyone's "pilgrimage" into better health.

61 yrs at the moment.

SW: 320

CW: 170

Not all was lost on Tirz/GLP. I had bariatric surgery in 2021, called a biliopancreatic duodenal switch. Which basically cuts out most of your stomach and re-routes your intestines to give you a life long malabsorption component...yes, it is extreme and if GLPs had been a thing back in 2021, I would have opted for that before this surgery.

Anyway, post surgery I got down to 180lbs, then ended up with a gangrenous gallbladder, that turned into sepsis and septic shock, and by the end of that run, I was very thin.

Drugs, steriods and everything else they gave me to keep me going, popped my weight back up to 230lbs, with a ton of inflammation.

Desperate and sick, I started to look into GLPs and the greater peptide world for some answers. Happy to say, Tirz got me down to 170 as of now...I also do NAD+ routinely. I have also ran a cycle of Epithalon. KLOW (individual vials/not blend), TA-1. Currently I am doing another cycle of KLOW to try and help with an old, chronic muscle injury.

My staple however is Tirz/NAD+ and GHKcu .

I have lots of lose saggy skin ...but I don't care. I love being able to swing a leg over my horses and be able to ride for hours and hours. Spanx is my friend, lol

 

[Good-Heart6425]

I’m 53 and on the pilgrimage with you. HW 365, CW 288, GW 199. Had bariatric surgery in 1999 and eventually gained all the weight back due to poor diet, the pandemic, and then menopause Tried Sema for 2 mos through local weight loss doc in 2023 lost about 10 lbs and experienced nausea often. Switched to Triz through Telehealth In January of 2025 and lost nothing the first 3 months and about 10 lbs total during April and May. Found this website in April and researched for about 3 weeks then placed my first grey order. Officially switched to grey in June 2025 and the scale started moving. I did experience extreme fatigue with Triz so started microdosing and added NAD which I pin 3x weekly. The energy and metabolism boost is very clean for me and I haven’t stalled. I also cycle KLOW every other month, my skin is flawless, and all those aches and pains gone! I still have saggy boobs, belly, and thighs but hell I gave birth to multiples and now over 50 so I’m giving myself grace. Y’all I feel so much better but can do better with exercising and expanding my diet. Eating mostly chicken and rice with mixed vegetables everyday. Looking forward to learning and sharing with everyone

I put pearl barley with a smidgen of lentils in my pressure pot for 15 minutes! The complex carbohydrate with legume protein is delicious, low glycemic index, and filling. Rice takes 20 minutes and is high glycemic index so I substitute with the barley.

 

[Good-Heart6425]

Welcome! I lived in Orange Park for a few years in the 90's!

My first 6 weeks on Tirz were tough. I was so tired. 8 weeks in those symptoms are resolving. I have much more energy now!

Yes, after 6 weeks compounded Tirz, sleepiness mode prevailed. Probably due to fasting hypoglycemia, but my logic circuits were shorting out too. Now at 10 months, at goal weight with multiple comorbidities quantitatively declined: brain fog, knee pain, pre-diabetes, pre-hypertension, reflux, irritable bowel, obstructive sleep apnea, keratoses and skin tags! Improved mood and energy.

 

[CandyCap]

I put pearl barley with a smidgen of lentils in my pressure pot for 15 minutes! The complex carbohydrate with legume protein is delicious, low glycemic index, and filling. Rice takes 20 minutes and is high glycemic index so I substitute with the barley.

Have you tried toasted buckwheat? Soooo good and quick in the pressure cooker! I fluff it up and add a dash of olive oil, a sprinkle of dill and salt and pepper. If I feel fancy, I add a fried egg on top.

 

[Good-Heart6425]

Have you tried toasted buckwheat? Soooo good and quick in the pressure cooker! I fluff it up and add a dash of olive oil, a sprinkle of dill and salt and pepper. If I feel fancy, I add a fried egg on top.

Wow, I’m gonna get some buckwheat to try! Thank you

 

[miche52]

As the title says I’m looking for input for other ladies over 50 who are on this pilgrimage (not a journey to me, that sounds too easy). I’m 59 and have been overweight since I hit puberty. Total hysterectomy at 44. No major health problems.

SW 322

CW 308

GW 200ish

I started December 15th on sema. I’m making decent progress. I’m up to .5 on dose but thinking about switching to tirz. I ordered a 30mg kit a while back. Going back and forth on changing and maybe doing a small sema kicker on my 3rd or 4th day each week if I need it. I have been having more cravings on day 6 and 7 each week.

I’m having trouble getting motivated to exercise. This happens to me every winter. I know that’s what it is. If I get my butt up and go to the gym I always feel better but depression is a killer to motivation. I’m on this mission alone. Nobody around me with time is interested in going with me so I’m gonna have to find that motivation alone. I did get a recumbent bike and some free weights and I’m trying to do that every day.

I've got my nutrition under control I think. Trying to hit the protein goal everyday but sometimes I miss. Making sure to get fiber every day and so far that has kept me and the toliet in good standing. I try to drink enough everyday but some days I feel like I'm gonna float off. I'm not counting calories because all the fatty foods I usually love is kinda gross to me right now. Plus after doing the calculation to see how many calories I would need to eat to maintain my weight I know I'm probably at half that amount. If you haven't done that yet, look it up.

I’m worried about the sagging skin! I’ve had so many surgeries in the last decade (mostly ortho stuff - back, hands, arm). I just got out of debt from having my gallbladder out but I consider that win with the GLP-1s. I know I’m not going to be a young hottie but I hate the idea of having to tuck and compress loose skin for the rest of my life or get it cut off.

Just looking for feedback from other mature ladies. Suggestions? Experiences you’re having?

52 year old. Started using compound GLP in Jan 2023. Started at 195. Currently at 163. My lowest has been 155. I been a yoyo dieter since my 20s. Would always drop weight fast but put it back on. Glps really have helped break the diet mentality. I haven't hit menopause officially yet but my instinct says this is the year (no cycle since September). I've been using HRT for almost a year which has helped with my symptoms. I get bloating from HRT but I'll take it over the mood swings, anxiety, no sleep and hot flashes.

I started on sema and lost very slow. Switched to tirz last year and I have less food noise. The highest dose I've used is 6 mg (grey). I've been a slow responder. Initially I was bummed but Im now grateful. I lifted weights a lot more the first year or so but not as much now. I walk 5-6 days a week which makes a difference in I feel overall.

I can't imagine what I would look like but more importantly how I would feel mentally and emotionally today had I not started using a glp. It's truly been a life saver.

 

[MsGizmo]

Well, I have only had 1 dose of NAD+ so far and it starts out with a low dose that I need to titrate up. I'll post results when I see any.

Now coming to the end of the SS-31 stage. The only thing I see is improved sleep. That probably due to the NAD+. But to be fair, if something is working in the background and healing something at the cellular level .. would I actually be able to tell the difference? After this protocol is over I intend to take a round of epitalon ... something that is supposed to improve the lifespan of my cells. For that I just have to trust the science.

 

[MsGizmo]

I put pearl barley with a smidgen of lentils in my pressure pot for 15 minutes! The complex carbohydrate with legume protein is delicious, low glycemic index, and filling. Rice takes 20 minutes and is high glycemic index so I substitute with the barley.

I love adding barley to my stew. My family loves it.

 

[Sidney]

I am 50 yo. 5’4” and about 188 lbs at highest and had high cholesterol/LDL that was impetus to start my health journey in 2021. I started with diet changes and added running and weight lifting over time. Lost 60lbs (to 124 lbs) in 18 months and cholesterol dropped to normal levels. Since then I hit perimenopause and my menstrual cycle became irregular and I started gaining weight (increased 15 lbs) and cholesterol started to creep up again.

Started Reta at 0.5 mg in September but was training for half marathon and it was interfering with long runs so I stopped for about 6 weeks until I completed the HM. I resumed Reta in November and lost 1-2 lbs per week since then. Today I hit my lowest weight of 124 lbs.

I am currently at 1.5 mg Reta / week. My goal weight is 120 lbs which I should hit in next 4 weeks, so I am already planning for what maintenance looks like (tapering down and maybe spacing dose). I do have some tolerable side effects and I am looking forward to reducing dose. I had to return to office about the same time I resumed Reta in November and really fell off running and weight training. I am really hoping to figure out time management and adding weight training back in when I am at maintenance and focus on body recomposition.

 

[vjorvj5150]

My bad.

Life has been in the way

Starting weight 225

Current weight 209

2/16/2026 current weight 200

 

[HZM808]

I’m on Reta and Tirz (4 mg of each), glutathione, NAD+, GH, KLOW and Melanotan.

Hi there, I was trying to search for info on if it makes sense to stack Glutathione and Melanotan 1 together and came across your post. Currently am pinning 1200mg of Glutathione once a week (this is my 5th week) and I think I'm seeing the skin lightening benefits, which I love. However, with summer coming quick to FL, I was thinking of trying the melanotan 1 as I'd love to see if the sun protection would help with my rosacea for which sun is the biggest trigger.

I'm a bit nervous as I do have melasma and some poikiloderma but I always start with the low n slow approach and have read it'll reverse. I've been on Klow for 16 wks and am cycling off that, so skin benefits could have been from that finally kicking as well as getting more consistent with melanin inhibitor skin care in prep for a peel I just did last week (mandelic bc I have rosacea).

I've done some searching but haven't really come up with anything. My concern is the Gluta and Melanotan will compete with each other in the skin dept. Did you find anything about that or did you notice anything that seemed that way?

 

[CNCCurrency]

Now coming to the end of the SS-31 stage. The only thing I see is improved sleep. That probably due to the NAD+. But to be fair, if something is working in the background and healing something at the cellular level .. would I actually be able to tell the difference? After this protocol is over I intend to take a round of epitalon ... something that is supposed to improve the lifespan of my cells. For that I just have to trust the science.

I follow a brit on youtube called the enhanced man. He runs cycles of epitalon and gets his blood work done thru epigenectics I believe and he show the improvements in telomere lengths and his biological age keeps going down with each cycle. You should check out his videos he is very informative.

 

[Wecandothis]

As the title says I’m looking for input for other ladies over 50 who are on this pilgrimage (not a journey to me, that sounds too easy). I’m 59 and have been overweight since I hit puberty. Total hysterectomy at 44. No major health problems.

SW 322

CW 308

GW 200ish

I started December 15th on sema. I’m making decent progress. I’m up to .5 on dose but thinking about switching to tirz. I ordered a 30mg kit a while back. Going back and forth on changing and maybe doing a small sema kicker on my 3rd or 4th day each week if I need it. I have been having more cravings on day 6 and 7 each week.

I’m having trouble getting motivated to exercise. This happens to me every winter. I know that’s what it is. If I get my butt up and go to the gym I always feel better but depression is a killer to motivation. I’m on this mission alone. Nobody around me with time is interested in going with me so I’m gonna have to find that motivation alone. I did get a recumbent bike and some free weights and I’m trying to do that every day.

I've got my nutrition under control I think. Trying to hit the protein goal everyday but sometimes I miss. Making sure to get fiber every day and so far that has kept me and the toliet in good standing. I try to drink enough everyday but some days I feel like I'm gonna float off. I'm not counting calories because all the fatty foods I usually love is kinda gross to me right now. Plus after doing the calculation to see how many calories I would need to eat to maintain my weight I know I'm probably at half that amount. If you haven't done that yet, look it up.

I’m worried about the sagging skin! I’ve had so many surgeries in the last decade (mostly ortho stuff - back, hands, arm). I just got out of debt from having my gallbladder out but I consider that win with the GLP-1s. I know I’m not going to be a young hottie but I hate the idea of having to tuck and compress loose skin for the rest of my life or get it cut off.

Just looking for feedback from other mature ladies. Suggestions? Experiences you’re having?

I am much older than you. Also had hysterectomy when I was 56. These work. I am at 127. I walk on the treadmill at least 30 minutes a day. I lift five pound weights at least two times a week. I do Reta with 2.5 tirz. Tirz helps with inflammation so I don’t want to stop it. I tried stopping it but felt like everything was hurting. I do have some skin sagging on arms and legs but that can’t be helped. Tirz with a little sema might be the winning ticket for you, I have done cagri, tirz and Reta all at once too. When I stalled I needed the extra boost. Just make sure you lift some weights, otherwise you are going to lose way too much muscle. And it’s very hard to get it back.

 

[chunkyTN]

I am much older than you. Also had hysterectomy when I was 56. These work. I am at 127. I walk on the treadmill at least 30 minutes a day. I lift five pound weights at least two times a week. I do Reta with 2.5 tirz. Tirz helps with inflammation so I don’t want to stop it. I tried stopping it but felt like everything was hurting. I do have some skin sagging on arms and legs but that can’t be helped. Tirz with a little sema might be the winning ticket for you, I have done cagri, tirz and Reta all at once too. When I stalled I needed the extra boost. Just make sure you lift some weights, otherwise you are going to lose way too much muscle. And it’s very hard to get it back.

Hi Wecandothis! I love your name. Yes, I added weight lifting 3 times a week along with riding my stationary bike every day (doing 2 miles a day now!). I had to start slow but it's getting better.

The GLP1s have helped with my inflammation too. I haven't progressed to Reta yet. I'm doing Sema and a tirz booster and that's working for now. It's also a budget option. I'm sure I'm gonna have saggy skin but it's just part of it.

My Mom was overweight and after she retired she just stopped doing anything. She got lymphodema and that led to a bunch of other things. Eventually she got a wound on her leg, didn't follow doctors orders, went septic and died. I AM NOT going to go that way. I'll take the saggy skin.

 

[FarmgirlRebel]

Question for you ladies.

Anyone stack Cagri with the GLP with success. I'm wondering if introducing a small amount of Cagri instead of titrating up on Tirz might be a better way to go.

I have no need to titrate up just yet, I'm losing well and staying satiated at 5mg...but thinking ahead.

 

[FlowerFairy]

Hi there, I was trying to search for info on if it makes sense to stack Glutathione and Melanotan 1 together and came across your post. Currently am pinning 1200mg of Glutathione once a week (this is my 5th week) and I think I'm seeing the skin lightening benefits, which I love. However, with summer coming quick to FL, I was thinking of trying the melanotan 1 as I'd love to see if the sun protection would help with my rosacea for which sun is the biggest trigger.

I'm a bit nervous as I do have melasma and some poikiloderma but I always start with the low n slow approach and have read it'll reverse. I've been on Klow for 16 wks and am cycling off that, so skin benefits could have been from that finally kicking as well as getting more consistent with melanin inhibitor skin care in prep for a peel I just did last week (mandelic bc I have rosacea).

I've done some searching but haven't really come up with anything. My concern is the Gluta and Melanotan will compete with each other in the skin dept. Did you find anything about that or did you notice anything that seemed that way?

You know I never thought about that! I’m ultra pale and Melanotan-1 did nothing. I switched to MT-2, and now instead of alabaster I’m lightly tanned. I never considered that my glutathione might be reversing my tanning effect.. I take 200 mg daily of the glutathione.. now I’m wondering if that’s why the MT didn’t work! I’ll have to stop the glutathione for a while to see if it works any better..

Thank you for pointing that out- I managed to miss it..

 

[CNCCurrency]

You know I never thought about that! I’m ultra pale and Melanotan-1 did nothing. I switched to MT-2, and now instead of alabaster I’m lightly tanned. I never considered that my glutathione might be reversing my tanning effect.. I take 200 mg daily of the glutathione.. now I’m wondering if that’s why the MT didn’t work! I’ll have to stop the glutathione for a while to see if it works any better..

Thank you for pointing that out- I managed to miss it..

i did mt 1 and tanned nicely and now using 200 glut 3 times a week with no loss of tan

 

[FlowerFairy]

i did mt 1 and tanned nicely and now using 200 glut 3 times a week with no loss of tan

I wonder if I took a break and used it to tan I’d have better results? I know maintaining is supposed to be easier than starting out..

(And Thank You!!)

 

[CNCCurrency]

I wonder if I took a break and used it to tan I’d have better results? I know maintaining is supposed to be easier than starting out..

(And Thank You!!)

I do a shot once a week to maintain. Have had a nice tan for 5 months straight