Hey over 50 ladies! Get in here, Let's talk

[Foggy-Hollow]

In October 2025 I also started Klow. I noticed a difference in my complexion almost immediately (by the third day) my skin looked brighter, more clear, vibrant. After two months I noticed my eyebrows were coming back (I won’t need microbladding anymore) and my eyelashes are thicker/fuller! My hair is filling in and growing out faster (it slowed down, and thinned a bit, since menopause)

So great to hear I've heard much good about klow.

I also ended up with intense itching, mostly in sweating bits, arm pits, back of knees, arm crease area, between boobs, just bacon grease splatter itching pain constantly, driving me crazy day and night. I haven’t heard that being a menopause symptom,

Have you tried estrogen cream? My ears will itch and I'll put a small tiny bit on a qtip. But it helps so much, especially with the lady-bits.

 

[Good-Heart6425]

52, I was gaining 10 pounds every year after menopause started, or after I started noticing symptoms, then one day I’m at work, and look in the mirror and said “who is that fat bitch!?”

It was a surprise thought, not a put down to myself, but once I saw it, I couldn’t not notice how big I was. I deep dove into things that help women in meno, found glp1s early on, but wanted to rebalance my hormones more than lose weight only. That was the logic anyway. I lost about 15 pounds changing my diet and taking Hrt, added extra progestron, and started taking sublingual sema, though a compounding pharmacy, the food noise was just gone, it was crazy.

Then I found online mainstream grey peptides and went crazy with it.(tirz, Reta, ipa, sermorelin, bpc 157 on and on) Then found grey china peptides. My sleep is good again, energy is back, down 50 pounds, skins skinning, not so many hot flashes, not much sweating, no b.o., really it’s been great. Still no sex drive, but there is something for that too.

The not sleeping was the worst for me, waking up, fully awake 30 minutes after going to bed, and having anxiety about it, waiting for the other unnamed shoe to drop, imaginary shoe. I also ended up with intense itching, mostly in sweating bits, arm pits, back of knees, arm crease area, between boobs, just bacon grease splatter itching pain constantly, driving me crazy day and night. I haven’t heard that being a menopause symptom, but when I hit puberty I got ulcerative colitis, so it tracks, another hormone shift/event could cause body inflammation that intense.

On Dupixant now, klow and added kpv and bpc from time to time. I thought it was blood cancer maybe, and was quuuuuoiiiittte upset (perhaps not the right word here) to have it be diagnosed as eczema.

Just losing weight helped joints, glp1s are honestly amazing, and anyone who wants to try them, should. It sucks how society tries to tell us it’s cheating or going to mush up our bones or whatever weird shit they come up with.

I hear you about itching. After 2.5 months of Tirz my torso was covered with scratched itch welts wherever my clothing compressed my skin. Dermatologist didn’t diagnose the cause, but prescribed prednisone which worked miracles…temporarily! Urticaria was due to the ketosis from mobilizing / excreting free fatty acids thru my skin. Have reached GW and reduced my Tirz dose. Now using oral anti-histamine daily.

 

[redhead]

I am 52, and have been overweight since my early 20s. 6 years ago I lost close to 100lbs through low carb and walking. I was still overweight and just could not get below 230 no matter what. I managed to keep it off for 4 years. 2 years ago it started creeping back on. I tried Tirz at Thanksgiving...life changing. So, here I am. SW264, CW250

I am also having trouble getting motivated to exercise. Tirz makes me so tired. I also much prefer to walk around in the woods than on concrete. I am not a gym person...just the thought of working out with people able to watch me freaks me out (yeah, I have other anxiety issues...LOL, Selank arrives tomorrow)

Omg. Almost identical story. Esp second paragraph. Love walking in the woods. Selank and semax arrived tues.

One Exception I’ almost To G155. (SW 207 CW 158.). I am now trying to figure out a 10 min at home work out I can do. Still in meditating on it.

 

[JuneBug1956]

I'm finishing the weg I got a prescription for ($199 a month coupon). I haven't had a lot of side effects except food noise creeping back in but I'm still at a low dose. I couldn't afford it going forward either. I looked at the monthly compound services but that's pretty expensive too. I saw gray mentioned and did a little digging and ended up here. What does your tirz microdosing schedule look like? I'm interested in that since day 6 and 7 for me I find myself really wanting to snack.

I Have done Tirz every 5 days. 7.5 mg twice weekly. Went up to 10 mg twice weekly then found that adding Sema at day 5 was the trick for me. I now do Tirz 10 mg weekly, Sema 2 mg once a week and a 2 mg Cagri once a week. Love how I feel. Lots of energy. This is my maintenance. SW 250, CW 140. 70 years old. As far as skin. I am crepey but weight lifting and swimming helped my core and gave me a cute shape. I will never wear tank tops but elbow sleeve is good

 

[cldfront]

Ladies, hello. 51F here, and a year and 5 months along the Tirz path. Happy to have lost 90 pounds, now stacking 1.8mg Survo with my 15mg Tirz to try to keep the loss going for hopefully another 25 - finally in 'overweight' land at 5'7" 190ish from 'obese III' starting at 280. If this is as good as it gets I will be so grateful.

Wanted to speak to two things - saggy skin (and the girls!) is a reality for me but not a huge BFD. I look for longer sleeves on short sleeve shirts as my most problematic area seems to be the underarm area of my upper arms. I've got a little full body melted wax look going on but I look the best I've looked in 25 years with clothes on so I'm cool with the trade.

Second - when I started over a year ago and immediately could tell this was going to work (!!) I stopped working out. I have a physical job, but I really completely quit with the exercising that only ever seemed designed to punish myself for being so fat. Yesterday, I went to the gym for the first time. Joined about a month ago, and it took me about a month to work up to going. They have a dark cardio machine room, which I thought I might like. And so here I am at the gym without a goal to 'get my shit together' and lose weight - I'm only there for health and strength and wellness. Ladies, I could RUN. And I could run without huffing like I was going to have a heart attack any moment. It was SO WEIRD. I did two miles of walk/run sessions over 30 minutes. And today, I can feel I did something but I'm not wrecked - no sore legs. I could totally go again today without pain. So all that to say don't sweat the exercise at the beginning if you don't want to or have associated it (like I did) with fat punishment. It will be there waiting for you when you're ready.

Lastly, I would like a serving of menopause, please. I am done with periods but periods don't seem to be done with me. Just started a Winona sub for some peri symptoms but I haven't missed a single bleeding day and I've been iron deficient for the past 8ish years. Boo.

 

[cldfront]

Oh and I meant to say I tried Reta and it did not agree with me. I thought I had food poisoning even at a 0.5mg dose - total sleep disruption and sprints to the potty. This seems like a really uncommon reaction but there it is. The Tirz/Survo stack is my friend.

 

[cldfront]

I hear you about itching. After 2.5 months of Tirz my torso was covered with scratched itch welts wherever my clothing compressed my skin. Dermatologist didn’t diagnose the cause, but prescribed prednisone which worked miracles…temporarily! Urticaria was due to the ketosis from mobilizing / excreting free fatty acids thru my skin. Have reached GW and reduced my Tirz dose. Now using oral anti-histamine daily.

Itchy skin seems to be my most persistent Tirz symptom. I am living with it and making sure to get plenty of lotion on the bad spots every day. I just got a spray Aquaphor moisturizer for my back/shoulder blades, which has been a game changer.

 

[BH_LOVER]

I'm finishing the weg I got a prescription for ($199 a month coupon). I haven't had a lot of side effects except food noise creeping back in but I'm still at a low dose. I couldn't afford it going forward either. I looked at the monthly compound services but that's pretty expensive too. I saw gray mentioned and did a little digging and ended up here. What does your tirz microdosing schedule look like? I'm interested in that since day 6 and 7 for me I find myself really wanting to snack.

I'm dosing about 3mg a week. I do start to get hungry before my next dose, but so far I'm still hanging between 125-130 so I'm happy with that. I will keep doing that until I notice changes.

 

[chunkyTN]

I've gotta say I'm thrilled to see there are so many of us here!

I don't always identify with the things the younger ladies are doing as far as lifestyle and diet. I'm aware that it's important for me to get nutrition! I can't starve myself and not have cramps and bathroom problems. It may be a slower path but it's what I have to do so I can lose and still be healthy. I'm a cancer survivor and I think the chemo did a number on some of my bodily functions as far as needing the vitamins and minerals in food. No more starving diets to lose 20lbs quick. I would be hurting for sure.

The other thing is exercise. I'm a self identified fat old lady with a bunch of ortho problems. My joints hurt and I can pull a muscle without even trying. I'm gonna just ease into the working out. I see some people saying it's not super important at first when you're still very over weight but who knows. This is a new frontier of weight loss and there are probably things we don't know yet.

 

[redhead]

I too am loving this thread and reading everyone's journey. Like a Crone Club - and I say that with all the love and respect as a witch and Meno lady that I am. I saw a clip that after giving our whole loves - giving to partners, kids, work, etc. We hit 50+ and it's finally our time to take care of ourselves.

That's what this whole journey feels like to me. Finally I am leaning in hard to self care and wellbeing. First it was the thyroid and adrenal fatigue in my early 40s. Then came PeriMen and it kicked my ass slowly and repeatedly for years until I nearly broke. Migraines, hot flashes, brain fog, exhaustion, blah blah blah. And the weight was a lifelong battle that I occasionally could win for a short bit then it would rebound and I'd be back at 180-190. Well Meno meant I just would continue to loose the battle and gain even more weight and up to 210 it went. Mind you I was doing Noom and 1200 calories a day when this happened.

So here I am...a true believer and super fan of the Semaglutides. When I cried enough to the OB about weight she quietly referred to me to the weight loss doctor - and SHE was the one who put me on Semaglutide. Life saver and game changer! Took me 2.5 years to loose 50#.

And when Kaiser stopped supporting The meds for overweight -- and I no longer qualified -- off to compound land went I. I am still there but now with my daughter off to college and the lifelong need -- I have HAPPILY arrived into this Grey World and am excited and researching my heart out. I'm currently on Tirz and love it. No interest in changing only titrating down slowly and maintaining. My to do list now includes Tirz and maybe Tirz + Low Reta? Not sure yet. And other peps: Klow, Semax, Selank, MotsC and SS-31. They are ordered and on their way. And exercise...I know I should be lifting weights but after work I just collapse and into a puddle. (high stress job + cozy couch and family). So am hoping for some help wit the SS31 + MotsC.

SW: 210 CW: 158 GW: 155 High School weight: 135-145. Love walks, hiking, hate gyms, want a work out at home routine that is 7-10 minutes. Love being here with y'all and sharing and learning!

 

[chunkyTN]

Sitting here tonight I thought about something else I wanted to ask. Anybody else have absolutely freezing feet? The rest of me is fine but my feet are so cold. Been sleeping with a heating pad for my frozen toes.

 

[Good-Heart6425]

Sitting here tonight I thought about something else I wanted to ask. Anybody else have absolutely freezing feet? The rest of me is fine but my feet are so cold. Been sleeping with a heating pad for my frozen toes.

Yes. I put my feet into the sleeves of a down jacket in bed, whilst I'm under a down comforter! Much of my fat is gone and my metabolism is somewhat lower with these GLP effects. I'm keping my circulation up with 90 minutes/day of road bicycle, but my finger/toe extremities are usually cold. Drinking hot water helps even just to hold the cup.

 

[FlowerFairy]

I’m almost 63. Semaglutide didn’t work for me, switched to Tirz, lost 80 lbs; still 40 lbs from goal but I swear my body is changing shape despite not losing right now. I’m on Reta and Tirz (4 mg of each), glutathione, NAD+, GH, KLOW and Melanotan. In menopause. My feet get cold easily so I sleep in knitted slipper socks. I’ve had an itching issue that was recently attributed to menopause.. I’ve not been a normal weight since age 3. I use a vibration plate and walk a lot. Had a duodenal switch w/biliopancreatic diversion in 2001; lost 120 lbs from that, then could not lose unless I was under extreme stress and those losses came back. Nothing worked until Tirz. I’ve lost more slowly, but it’s coming off so I’m happy.

 

[skeptick]

I've gotta say I'm thrilled to see there are so many of us here!

I don't always identify with the things the younger ladies are doing as far as lifestyle and diet. I'm aware that it's important for me to get nutrition! I can't starve myself and not have cramps and bathroom problems. It may be a slower path but it's what I have to do so I can lose and still be healthy. I'm a cancer survivor and I think the chemo did a number on some of my bodily functions as far as needing the vitamins and minerals in food. No more starving diets to lose 20lbs quick. I would be hurting for sure.

The other thing is exercise. I'm a self identified fat old lady with a bunch of ortho problems. My joints hurt and I can pull a muscle without even trying. I'm gonna just ease into the working out. I see some people saying it's not super important at first when you're still very over weight but who knows. This is a new frontier of weight loss and there are probably things we don't know yet.

Consider going to a swim pool and maybe just walking back and forth starting in the shallow end. Just swinging your arms in the water is a good no-impact exercise. You go girl...

 

[MsGizmo]

My to do list now includes Tirz and maybe Tirz + Low Reta? Not sure yet. And other peps: Klow, Semax, Selank, MotsC and SS-31. They are ordered and on their way. And exercise...I know I should be lifting weights but after work I just collapse and into a puddle. (high stress job + cozy couch and family). So am hoping for some help wit the SS31 + MotsC.

Read up on this (mitochondria protocol) since you've already ordered 2 of the 3 peptides involved. Many of us have already done it and I just started mine. The dosing schedule is on the first 2 pages and all the science that developed the protocol is included in the next 15 pages. I will fully admit that I didn't read all of if but I read enough to convince me that trying it has a good chance of helping me. Its a longish read so here is a Video of dude discussing the mitochondria protocol.

Another peptide suggestion for my fellow crones to research .. epitalon. I bought some of this and intend to take a round of it after I finish the mitochondria protocol.

 

[chunkyTN]

Consider going to a swim pool and maybe just walking back and forth starting in the shallow end. Just swinging your arms in the water is a good no-impact exercise. You go girl...

I wish I could find a place that didn't cost a fortune! In middle TN any place with a pool requires a membership that is out of my price range. Once it warms up I'll do that in my own pool tho.

 

[CandyCap]

Omg. Almost identical story. Esp second paragraph. Love walking in the woods. Selank and semax arrived tues.

My selank and semax arrive today! I am prepped with everything to make nasal sprays as soon as it arrives!

 

[PunkN]

Hello!!! I turned 53 in October. I have always worked out and was in pretty good shape. Lifting, spin classes, practicing and teaching yoga for years. Even with all that I was steadily gaining weight every year. When Covid hit it derailed my group fitness. I bought a spin bike and taught online yoga classes but the isolation got to me. I didn’t realize at the time I was in full menopause. Dark thoughts and all that fun.

In 2021 I ended up in the ER with high BP and began taking Lisinopril and a statin. In 2023 I had a semi breakdown one morning. Couldn’t remember my yoga pw at the studio that I had used for a decade. Was diagnosed with hypothyroidism and began levothyroxine. Had to quit teaching yoga at that time.

So really fun times. A guy who worked with my husband lost a lot of weight and told him about taking tirzepatide. I read everything I could and joined all the forums/reddits. We started in July 2024. I’ve lost over 90lbs which it seems crazy I had that much to lose tbh.

Been fully post menopausal since 2023. We just got our GHK-cu, Epithalon, and KPV today. I currently take 3.5mg tirz and just upped my Reta to 6mg. I could be at maintenance but kinda want to lose about 5 more lbs.

I am so thankful for these glps. My husband and I agree they saved our lives. I no longer take the lisinopril or the statin. My BP is great. I will probably have to be on my thyroid meds for life but I am ok with that. Taking HRT now and will never quit my glps.

 

[skeptick]

I wish I could find a place that didn't cost a fortune! In middle TN any place with a pool requires a membership that is out of my price range. Once it warms up I'll do that in my own pool tho.

Me never bin to TN. On West coast most all high schools have pools that are open for public swims. Just thinkin out loud...

 

[Foggy-Hollow]

Read up on this ( mitochondria protocol ) since you've already ordered 2 of the 3 peptides involved. Many of us have already done it and I just started mine. The dosing schedule is on the first 2 pages and all the science that developed the protocol is included in the next 15 pages. I will fully admit that I didn't read all of if but I read enough to convince me that trying it has a good chance of helping me. Its a longish read so here is a Video of dude discussing the mitochondria protocol .

Another peptide suggestion for my fellow crones to research .. epitalon. I bought some of this and intend to take a round of it after I finish the mitochondria protocol.

reads wiki

Extends telemeres! Sweet! There it is folks, anti-aging it a bottle.

Weight loss in a pill, anti-aging in a bottle... the future's here. I'm okay not having flying cars.