Have you stopped taking your GLP, and if so what happened?

[GLP1Pharmacist]

Yeh, hopefully. It was a minimum of 10 days but I jab on Sundays so it'll actually be a full 15 by the end of surgery day!

It's a lifelong battle, so don't worry too much about a speed bump, good luck

 

[Dillydally7]

If still losing 0.5-2lbs per week ride it out. After 2-3 weeks of no loss, I would up tirzepatide since you tolerate it and know what to expect. Just my 2 cents.

Yeah I think I’ll do that thanks - currently losing about 3-4lb a month so about right.

 

[littledragon25]

It's a lifelong battle, so don't worry too much about a speed bump, good luck

Oh yeh, I know that. I've been losing weight for going on 2 years now in one way or another and am 136lb down. But I am just not looking forward to the hunger that will likely hit me mid week!

 

[keangkong]

This is what worries me about stopping - I still have a stone or so to go yet. I’m currently on 10mg tirz but don’t know whether to increase it or add in reta. At least I have the option which I’m lucky to have I guess.

I’d recommend slowly increasing your tirz so long as you continue to tolerate it.

 

[Bunny]

I was on tirz 7.5mg (at maintenance). Suddenly developed severe anxiety for no reason whatsoever. Bedridden. Immediately came off. Put on 12.8lbs in the month I was off. Bloated tummy. I looked pregnant (I'm 75!) Tried reta but elevated heart rate so started back on tirz. Lost weight gain in three weeks very easily. Now very happily maintaining on 5mg tirz with a "top up" of 1mg sema. No side effects. No anxiety. Bodies are weird No need to worry, just a minor blip. You'll be fine. Wishing you a speedy recovery.

 

[Wolfman]

Been off for two months with little weight gain. Been taking Tesofensine 250mgs-500mgs. Has helped with appetite suppression and energy. Holding at 170 if I get above 175 I take a shot of triz maybe just once a month and it knocks me back down.

 

[psycho_driver]

I took Sema from Nov 24 to Apr 25 and lost 21lbs. I stopped for about two months and gained 15lbs back. This is a pretty crazy amount of weight gain for me in that short of a time span. I normally put on 3-4lbs per year when going through gaining phases of my life. That was a bit concerning.

The good news is that I lost 13lbs my first week on tirz after starting back up. I'm down 32lbs on the year currently and have 2+ years stock of reta now (more hopefully depending on what my maintenance dose ends up being).

 

[Longstory]

I couldn’t afford to buy my next pen or tirz for 7 days. The hunger was bad but I stuck to my usual calories and exercise… I put on 10lbs.

How the hell did that happen? Tirz works on bodies in many different ways- not just appetite suppression. The lipedema seemed to swell back up before my eyes. I’m not sure I will ever be able to be off this if I want to be a healthy weight.

 

[kroert99]

I stopped for a short time switching from sema to Reta, apetite increasesed, I followed a strict program so I don’t gain any weight but damn bro, my cravings for sugary things came in hard! Only thing I could think about was the candy drawer in my home.

I was so hungry on reta and when I got to the higher therapeutic dose, I had diarrhea that was unbearable, so I am back on sema/tirz and stack it and helping maintain my weight and helps with food somewhat.

 

[karib574]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

Since coming off in June he has gained back 20 pounds. He says he is eating the same as when he was on sema. I'm a little skeptical of that, but I don't see him much so I don't know. So now he's feeling crappy and depressed. He's going to start working out more to see if that combats the gain.

 

[Longstory]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

Since coming off in June he has gained back 20 pounds. He says he is eating the same as when he was on sema. I'm a little skeptical of that, but I don't see him much so I don't know. So now he's feeling crappy and depressed. He's going to start working out more to see if that combats the gain.

Skeptics my entire life have told me calories in calories out… it’s as simple as that. If that was true then I wouldn’t have needed this medication at all. There’s a lot of research out there to prove that it works to combat insulin resistance amongst other things. It can also change the composition of fibrotic fat seen in lipedema patients.

There is much more research needed to understand all the mechanisms of Glp1’s and the effects on the body.

I’m living proof that calorie intake and calorie expenditure and a calorie deficit- doesn’t always equal weight loss.

 

[cookieguggleman]

I’m in overeaters anonymous which has been a life changer for my BED and bulimia. I want the sanity and the vanity. Tirz is just one of many tools I use, I can’t rely on it 100%

 

[keangkong]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

Since coming off in June he has gained back 20 pounds. He says he is eating the same as when he was on sema. I'm a little skeptical of that, but I don't see him much so I don't know. So now he's feeling crappy and depressed. He's going to start working out more to see if that combats the gain.

Calories in, calories out. That has turned out to be basically accurate, according to numerous nutritional studies, although nutritionists can tell you a million ways that you may be influencing calories out that were not aware of.

Tirzepatide has been tested to see if it increases metabolism. Tirzepatide has little effect on overall metabolism.

People are poor historians of their dietary habits. (I exempt serious body builders from that generality. They have to be precise in what they eat since they're constantly intentionally going up or down in weight.) I believe it feels like he's eating the same amount of food. He's being a normal human by thinking so.

I recently had to stop retatrutide due to possible liver problems. I'll likely start again soon. On the tirzepatide alone, I don't feel like I'm eating too much. However, my weight keeps increasing. The FEELZ test for how much we're eating is usually a poor indicator. Keeping dietary records, is strictly followed and accurately done, reveals valuable information but it's unusual for a person to consistently and strictly track all food and exercise.

Apparently, reta causes a slight increase in metabolism. Mazdutide also causes an increase in metabolism.

 

[Longstory]

Calories in, calories out. That has turned out to be basically accurate, according to numerous nutritional studies, although nutritionists can tell you a million ways that you may be influencing calories out that were not aware of.

Tirzepatide has been tested to see if it increases metabolism. Tirzepatide has little effect on overall metabolism.

People are poor historians of their dietary habits. (I exempt serious body builders from that generality. They have to be precise in what they eat since they're constantly intentionally going up or down in weight.) I believe it feels like he's eating the same amount of food. He's being a normal human by thinking so.

I recently had to stop retatrutide due to possible liver problems. I'll likely start again soon. On the tirzepatide alone, I don't feel like I'm eating too much. However, my weight keeps increasing. The FEELZ test for how much we're eating is usually a poor indicator. Keeping dietary records, is strictly followed and accurately done, reveals valuable information but it's unusual for a person to consistently and strictly track all food and exercise.

Apparently, reta causes a slight increase in metabolism. Mazdutide also causes an increase in metabolism.

I’ve been keeping strict diet diaries. Not just for myself, but for my daughter who’s part of an NHS programme that requires it. I’ve worked with the dieticians, nutritionists and a speciality endocrinologist nurse and consultant for the past 2 years. They are doing research into genetic obesity with genetic testing involved. My body composition at the moment says that I should be able to consume 1600cals and maintain. However, after many months we’ve found out that that’s not the case. It can be due to many factors but the likely cause is predisposition of fat accumulation and a mixture of lipedema and pcos.

Of course that doesn’t even take into account the amount of aerobic activity and core training that I do, in theory I should be able to eat more and not gain- however, again, the theory was wrong.

Working with the team we hope to shed more light on genetic obesity and isolate the genes involved. It’s eye opening for sure.

I do know that nearly all patients have a period of weight gain after stopping Glp1’s. Some were diet related- but not all.

 

[psycho_driver]

My brother is one of those who has permanent vision loss in one eye, apparently due to sema, so he has been off since June and won't ever take it again since he doesn't want to risk losing vision in both eyes.

If you don't mind my asking a few questions I'm really curious about these cases.

Is he diabetic, pre-diabetic or neither as far as you know?

Was he losing at a healthy 1-2lbs/wk or was it more?

Did he have any warning signs prior to the loss of vision?

Do you feel there were any other factors that could have contributed to the vision loss outside of GLP-1 use?

 

[keangkong]

I’m in overeaters anonymous which has been a life changer for my BED and bulimia. I want the sanity and the vanity. Tirz is just one of many tools I use, I can’t rely on it 100%

Fortunately, tirzepatide is around to help people. Often, however, more needs to be done.

 

[karib574]

If you don't mind my asking a few questions I'm really curious about these cases.

Is he diabetic, pre-diabetic or neither as far as you know?

Was he losing at a healthy 1-2lbs/wk or was it more?

Did he have any warning signs prior to the loss of vision?

Do you feel there were any other factors that could have contributed to the vision loss outside of GLP-1 use?

Sorry, the only thing I know for sure is that there were no warning signs. I think he said he woke up one morning and his vision was messed up. Sucks because it affects so much, messes with his balance, dizziness from not being used to using one eye, headaches. Ugh. He joined the class action lawsuit.

I'm fairly certain there were no other factors. I can't imagine what else it could have been. It happened in June, I think he'd been on it about a year. He lost I think maybe 60 pounds?

 

[keangkong]

Sorry, the only thing I know for sure is that there were no warning signs. I think he said he woke up one morning and his vision was messed up. Sucks because it affects so much, messes with his balance, dizziness from not being used to using one eye, headaches. Ugh. He joined the class action lawsuit.

I'm fairly certain there were no other factors. I can't imagine what else it could have been. It happened in June, I think he'd been on it about a year. He lost I think maybe 60 pounds?

Ozempic and vision loss: GLP-1 drugs may double risk of eye disease

New research links semaglutide and tirzepatide, which are GLP-1 agonists used to treat type 2 diabetes and aid weight loss, to a rare eye disease that may cause vision loss.

www.medicalnewstoday.com