tex182 said:
Do you have one that you prefer or that you think is helping the most? I know if you're stacking it's probably difficult to discern side effects and benefits of each individual peptide. My RS is using only Tirz at 7.5mg with minimal side effects save for occasional nausea and abdominal pain but has been curious about adding reta so I'm very interested to hear people's personal experiences with it! I have not looked into cagri though.
The story arc in my Grand Tour has been from “easy, long-term weight-loss with full appetite supression and no calorie-counting on Sema TO a stalling-out fall-from-bliss TO six months of effortful-three-different-peptides-uphill-both directions struggle to regain weight-loss Heaven”.
Soon to be made into a major motion picture!
I have pretty well kept the peptide transitions distinct and can accurately distinguish their contributions.
I was hoping to delay publishing about this until I had more experience to report on.
BRIEFLY stated with the minimum of detail :
After 10-11 months successful Semaglutide weight loss I stalled out.
How can you keep on movin' unless you migrate too.
For me the difference in appetite suppression between Semaglutide and Tirzepatide was considerable and stimulated me to titrate rapidly to 7.5mg weekly. It wasn’t enough. Migrating to Tirzepatide reduced side effects but 10mg weekly dosage was required to approach the appetite suppression of Sema. More than 10mg weekly would have been needed to actually equal 2.5mg of Sema weekly.
Stack, stack, stack... they call him The Stacker.
Began stacking 2.5mg of Reta mid-week atop 10mg of TIrzepatide to assist with suppression.
It assisted well! Reta does have somewhat better appetite suppression than Tirzepatide. It soon became clear that the mid-week Reta was doing the heavy lifting and I quick-migrated to 7.5mg of Retatrutide dosage in about three weeks
Rinse and repeat.
Retatrutide is better in every way than Tirzepatide is - for me . Explaining the subtle whys becomes difficult. Certainly there are fewer side effects with Retatrutide than with Tirzepatide; my persistent side is constipation which I treat with Magnesium Citrate gelcaps. Fairly soon the 7.5mg dosage was not sufficient to quell my appetite and I needed to upgrade the dose. Reta unfortunately has the same difficulty for me that Tirzepatide does but not to the same degree - not quite adequate appetite suppression at 10mg weekly.
Enter the Dragon.
At risk of appearing a weak and needy addict, I admit to now stacking Cagrilintide mid-week atop 10mg of Retatrutide. This is strictly to stop the onset of significant hunger which was stalling me out AGAIN.
I decided on the addition of Cagrilintide mid-week
My intention was to start with 0.300mg but I fumbled the dose calculation or draw. Thankfully I experienced no strong side effects.
The main effect however was substantial - Appetite Suppression At Last!
Cagrilintide ELIMINATED my hunger for 7 days :
I lost 5lbs from Wednesday through end-of-day Sunday!
Based on my recent experience some things seem to be true:
a) Stacking Reta atop Tirz is not efficient or particularly effective.
This seems evident in hindsight as 2/3 of Retatrutide's agonists
duplicate Tirzepatid's agonists;
b) Both peptides have the same "weakness" - they don't suppress appetite nearly so well as Semaglutide.
c) Initial response to Cagrilintide is that its appetite suppression is equal to that of Semaglutide if not greater.
d) If your appetite breaks through while taking high dosages of Tirzepatide adding Cagrilintide is a far better solution than adding Retatrutide.
This data is of course only true for me. Your Mileage May WILL Vary!
