scout5
GLP-1 Novice 🚫No Source Discussion🚫
GLP-1s Show Promise for Knee Arthritis, Improving Cartilage Even Without Weight Loss, Study Finds
- Thread starter scout5
- Start date
- Status
Beast-of-Burnley
GLP-1 Novice 🚫No Source Discussion🚫
Interesting, i have osteoarthritis and I have seen a significant improvement in my own knee pain / general knee health (took branded Mounjaro for about 4-5 months with the golden dose then grey Reta for the last 2 months ish) since losing just over 6 stone in around 10 months.
i had contributed the massive improvement to the weight loss but perhaps there was some other help from the glp's!
i had contributed the massive improvement to the weight loss but perhaps there was some other help from the glp's!
It’s always interest when these “news” outlets report something regarding glp-1 usage like it’s a new finding. The clinical study on the effects of OA knee pain and sema was published 18 months ago…
https://www.nejm.org/doi/abs/10.1056/NEJMoa2403664
https://www.nejm.org/doi/abs/10.1056/NEJMoa2403664
oldrunnerguy
GLP-1 Apprentice
One more reason now added to the list of why I'm taking a GLP1. So far here's my list, not ranked in any particular order:scout5 said:
1. Reduction in A1C.
2. Improved lipid profile.
3. Reduction in arthritis-related pain.
4. Significant reduction in the urge to binge on chocolate.
5. Reduced visceral fat percentage, according to my scale.
6. Reduced risk of Alzheimer's disease.
7. Reduced risk of adverse cardiovascular events (myocardial infarction, etc.)
8. Lowered blood pressure.
9. Reduced risk of colorectal cancer.
10. Definitely least important for me, is reduced body weight. I do not need to lose weight, but being a vain person, I look pretty good in the mirror.
Feel free to add more reasons.
Grogu said:
I think there is a big difference between those two. The study you cited (funded by Novo) aligns weight loss to OA improvement. That is not a big shocker as the common statement is “The load on your knee joint decreases by approximately 4 pounds for every pound lost.”. So any loss in weight would lead to some pain reduction.
The newer study is making yet another linkage to GLP doing things we don’t quite understand. I sit at the center of the Venn diagram for several and I am following closely. Last year was impact to heart issues above and beyond what can be counted on based on weight loss alone. This one suggests OA improvement beyond weight loss alone and the added benefit of cartilage remodeling which hasn’t been seen in prior studies.
Zydeceltico
GLP-1爱好者
- Member Since
- Oct 10, 2025
- Posts
- 6
- Likes Received
- 0
Same....and I am also following closely with vested interest.jw717us said:
From personal experience I am now around 9 months and 49 pounds down. BMi just dipped under 26. Fat% from 26 and change to 18.5 with a corresponding gain in muscle.Zydeceltico said:
The practical results:
Apnea - Off CPAP
Afib - Off meds
OA - No pain, no weakness and just some residual crepitis crackle in one knee climbing stairs.
Binge drinking - Gone
I’m actively watching the studies to help me understand what the heck all the GLP receptors are tied into. Weight loss alone isn’t it.
jw717us said:
Thanks! I looked at this study again and it wasn't the one I was thinking about. I'm going to have to go back and see if I can find the research article I was thinking about. It's possible I was thinking of OSA and not OA, but I could have sworn it was both.
I remember thinking that it's not surprising that with a reduction of weight that there would be improvements in OSA and OA and how the researchers would be able to tease out what portion of the effect was related to weight-loss and what portion wasn't.
Grogu said:
Agreed 100% When I read the earlier one, and saw it was from Novo, my first take was a solid "well duh!" They might as well have funded a study showing that GLP1s had a direct correlation to pants size?!?!?
Jerrey
GLP-1 Apprentice
Yup, tirz has been show to have very effective anti inflammatory effects for quite some time also. I think most of us just assume pain reduction is all because of the seemingly magical weight loss, but the GLPs have other benefits for us old arthritic folks as well.Grogu said:
buffoon24
GLP-1 Novice 🚫No Source Discussion🚫
The hypothesized mechanism shown in this Cell paper is wild! GLP-1 receptors are present across lots of different cells and not just the pancreas and gut. The study shows that chondrocytes express GLP-1 receptors, meaning your Tirz/Sema/Reta etc. can act locally on cartilage cells. The mechanism of action is more anti-inflammatory than metabolic.
Crumplestiltskin
GLP-1 Apprentice
I'm very interested in this list, especially the arthritis related pain! I don't need to lose weight either, so I'm wary about dropping too much or something, but these benefits are incredible. I have had bad knees since i was a teenager, and it's only worsened. Which did you take for those benefits?oldrunnerguy said:
oldrunnerguy
GLP-1 Apprentice
currently on Reta, about to switch to TirzCrumplestiltskin said:
Dogmandu
GLP-1 Apprentice
May I ask why? Many go the other direction, from Tirz to Reta. Phase 3 data on Reta and osteoarthritis was very positive.oldrunnerguy said:
This is a great study with real implications. The important question that this raises is whether stopping glp1s leads to a loss of the benefits that are independent of weight loss.
A follow up study that looks at this would raise an argument that glp1 should not be stopped for treatment of osteoarthritis regardless if weight goal is achieved.
A follow up study that looks at this would raise an argument that glp1 should not be stopped for treatment of osteoarthritis regardless if weight goal is achieved.
SoCalGirl
GLP-1 Novice 🚫No Source Discussion🚫
Do you think this is semiglutide-specific, or will RETA and TIRZ also work?
This study used a mouse model for OA and proposes glp1 protection through activation of a pathway in chondrocytes. The presence of glp1 receptors in chondrocytes would suggest that any drug that activates glp1 would activate the same pathway and offer the same benefits.SoCalGirl said:
Crumplestiltskin
GLP-1 Apprentice
I'm really interested in that aspect, too. Would this act like more of an anti-inflammatory, or does it actually repair?Ragnar said:
- Status
