副作用：腹泻

[Der Erlkasper]

我目前还在服用2毫克的剂量，上周出现了严重的腹泻，后来慢慢缓解了。

我不确定这是不是某种不干净的蔬菜引起的，还是真的是Reta的副作用，因为感觉很像食物中毒。

有人遇到过这种情况吗？这种症状符合已知的副作用吗？我应该降低剂量，还是停药一周？

 

[miss-sanne]

这是常见的副作用。如果是在服药后出现，很可能是利尿剂引起的。我建议尝试将剂量减至 1 毫克。

 

[Der Erlkasper]

这是常见的副作用。如果是在服药后出现，很可能是反应。我建议尝试将剂量减至 1 毫克。

这种情况发生在第三周。目前为止，每周服用2毫克。

 

[miss-sanne]

这种情况发生在第三周。目前为止，每周服用2毫克。

我怀疑是丝虫病。它会在你的体内积聚。

 

[lessthanhalf]

该药物对肠道蠕动的影响并不完全合理，因为它可能导致便秘或腹泻。在持续服用该药物的情况下，血药浓度会在4周后达到峰值，因此每次服药后一两天内血药浓度应该达到峰值，并且每周略有升高。https ://glp1plotter.com/ 网站有助于可视化该药物的吸收过程，因为它与其他药物截然不同，吸收缓慢，半衰期长达一周。副作用与血药浓度峰值相关。

我同意先将剂量降至1毫克一段时间，然后再缓慢增加剂量，下次增加到1.5毫克。一般来说，胃肠道副作用通常在服药后的1到3个月内最为严重，之后大多数人的副作用会逐渐减轻，缓慢增加剂量是最大限度减少副作用的最佳方法。

 

[AxlBundy]

我服用瑞达（Reta）已经18周了，最近把剂量从每5天3毫克增加到每5天5毫克，之后就出现了爆炸性腹泻。增加剂量的时候我也换成了吉普瑞达（Jeep Reta）。我有一些猜测，但服用易蒙停（Imodium）似乎有效。希望这只是短期的适应性反应。

 

[Calm Logic]

一些适合在浴室阅读的书籍：

正常的副作用？

我之前每周注射5毫克，每次注射后都会腹泻几天。昨晚我注射了10毫克，醒来后副作用非常严重：除非待在空调很冷的房间里，否则会大量出汗；当然，还会腹泻；胃痛；还有点头疼。最主要的问题是胃痛……

glp1forum.com

还有其他人像我一样，在腹泻时大便里会排出大量未消化的食物吗？

Maybe its also due to diet change as I am eating more veg and salads and stuff, but its a bit wierd to be shitting out leaves and bits of carrot and crap. Especally 2 days out from a dose, for some reason. For some reason the triz sides hit @ 48 hours out from a dose.

glp1forum.com

Lower starting doses

So should people start on 1.0 mg of tirz? I don't think so. There's always exceptions, but almost no one does that. The 2.5 mg dose is considered the lowest, initiation dose for tirz, with a current maximum of 15 mg that is six times that. I think part of the confusion is because people lose...

glp1forum.com

Might retrutide work better for me

I have been taking tirzepatide for a little over three months and have ran into problems that are stopping me from getting to an effective dose. I worked my way up to a dose of 5 mg of tirz once weekly. About three days into the week, I got debilitating diarrhea and bothersome insomnia...

glp1forum.com

What I don't see enough of: People using

telehealth to manage GI symptoms. A person could even schedule weekly telehealth appointments with a board-certified internist. Or just use Amazon telehealth as needed. But the microdosers, to be consistent, may want to microdose GI meds too, haha.

 

[randompersonrandom]

Some bathroom reading material:

Normal side effects?

I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach...

glp1forum.com

Anyone else get a good bit of undigested food in stool as a triz side?

Maybe its also due to diet change as I am eating more veg and salads and stuff, but its a bit wierd to be shitting out leaves and bits of carrot and crap. Especally 2 days out from a dose, for some reason. For some reason the triz sides hit @ 48 hours out from a dose.

glp1forum.com

Lower starting doses

So should people start on 1.0 mg of tirz? I don't think so. There's always exceptions, but almost no one does that. The 2.5 mg dose is considered the lowest, initiation dose for tirz, with a current maximum of 15 mg that is six times that. I think part of the confusion is because people lose...

glp1forum.com

Might retrutide work better for me

I have been taking tirzepatide for a little over three months and have ran into problems that are stopping me from getting to an effective dose. I worked my way up to a dose of 5 mg of tirz once weekly. About three days into the week, I got debilitating diarrhea and bothersome insomnia...

glp1forum.com

What is up with the way humans just LOVE to tell poop stories. I feel like across all cultures and all timelines, there is always a gaggle of humans who's here to tell you all about their pooping.

 

[MFGamesta]

It happened to me my 2nd week of tirzapatide and again the 2nd week of retatrutide. Only happened once. I while try to stick it out for another week to see if it fades.

 

[Minkster]

I had it in the beginning for a few days and maybe a day after a dose increase but mostly constipation is my issue.

 

[Calm Logic]

Soluble fiber supplements may also help, though it may seem counterintuitive since they are also used for constipation.

In addition to probiotics like Florastor Advanced, the controversial supplement kratom is another long-term option (due to the mild opiod-like effects slowing down the lower GI system).

What is up with the way humans just LOVE to tell poop stories. I feel like across all cultures and all timelines, there is always a gaggle of humans who's here to tell you all about their pooping.

Diarrhea is the side effect my pharmacist warned me the most of, as far as why people stop taking tirz completely. For many on GLPs, this is the worst diarrhea they will have in their entire lives, especially if they had IBS-D before.

 

[Dogmandu]

It happened in week 3. Weekly 2mg doses so far.

This is not unusual, as week 4 after first shot as that's when the reta level begins to peak and plateau. So, expect some additional troubles this week and next.

You have options:

1) go back to 1 mg or 1.5 mg and stay there for a month. As your body gets used to that dose, go up slowly to 2 mg. Your escalation may have to be slower to allow your body time to adjust.

2) stay the course and deal with it (not my preference) and hope your digestive system adapts sooner than later.

3) pay attention to what type of foods triggered the issue. When I started, fatty or oily foods would cause problems. You may be able to stay at 2 mg as long as you avoid triggering foods.

Of course, it is also entirely possible that you got a case of food poisoning, but I doubt it.