Enclomiphene Experience (12.5mg): Higher Test, Better Recovery, Leaner Build

[Diamondd817]

It actually doesnt matter when you take it, you'll still get larger pulses at night. When prescribed, there is nothing on the prescription that says you have to take it at night.

This is true.

 

[Airborne Daddy]

I’m on the enclomiphene 12.5 mg/ tandalafil 8.5 mg daily from H/H for 90 month which includes quarterly testing. My T started at 200 and after 2 months I was at 500 and my online provider declined to bring my prescription up to the 25mg a day as my T was increasing quicker than expected.

I am hoping that my natural production will increase as my weight decreases and I correct my insulin resistance. My A1c has fallen significantly since I started the tirzepitide, however my fasting insulin is still higher than I’d like to see. I’m hoping that the mots-c, Ss-31, and NAD+ protocol is going to help. I am resistant to the Testosterone oil shots, as I am focusing on one aspect of my health at a time.

Insulin resistance and testosterone

1. The Direct Hit to the Testes

Research shows that insulin resistance directly impairs the Leydig cells in the testes. These are the cells responsible for churning out testosterone. When your body is resistant to insulin:

• The Leydig cells become less responsive to Luteinizing Hormone (LH)—the "start engine" signal from your brain.

• Even if your brain is screaming for more testosterone, the testes don't "hear" the signal as clearly, leading to lower output.

2. The "Belly Fat" Factor (Aromatization)

Insulin resistance is almost always tied to increased visceral (belly) fat. This fat isn't just storage; it’s metabolically active and contains an enzyme called aromatase.

• Aromatase takes the testosterone you do have and converts it into estrogen.

• Higher estrogen levels then tell your brain, "We have plenty of hormones," which causes the brain to slow down the signal to produce more testosterone.

3. SHBG Suppression

Insulin levels significantly influence Sex Hormone Binding Globulin (SHBG), a protein that carries testosterone through your blood.

• High insulin levels signal the liver to produce less SHBG.

• While this might sounds like it would leave more "free" testosterone, low SHBG is often a marker of metabolic dysfunction and is consistently linked to lower total testosterone levels over time.

4. Inflammation and the Brain

Chronic insulin resistance creates a low-grade inflammatory state. This inflammation can disrupt the Hypothalamic-Pituitary-Gonadal (HPG) axis. Essentially, the "command center" in your brain becomes less efficient at monitoring and regulating your hormone levels, leading to a drop in production.

The Silver Lining: Reversibility

The good news is that because this relationship is bidirectional, fixing one often helps the other. Improving insulin sensitivity—is one of the most effective "natural" ways to boost testosterone.

I was running 108-10 fasting glucose.... mots c i did 5mg, three times a week, got me down to high 90's.

 

[swimmer]

Just curious if anyone knows or maybe it isn't something that can be known...Couldn't find any definites with my lazy online search.

Does Enclo increase body hair by way of increased test?

I'm 39...and a half....I dont want hair to just appear on my back all of a sudden.

Basically just don't want to get sasquatch hair.

Anyone have experience or input would be appreciated.

I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.

 

[Smiter]

I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.

What about your swimmers?

 

[MTSpace]

Clomid gave me the Clomid Crazies. I am researching Enclomiphene as I am struggling on TRT Test Cyp/Enan with Erythrocytosis. Curious to what you hematocrit is and escpecially if your test levels continue to rise. My hematocrit did not raise nearly as much on Clomid, but I was losing my mind and also concerned about floaters since I was experiencing sides.

 

[Mr. Blonde]

I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.

Nice, thanks.

 

[swimmer]

What about your swimmers?

I don't know if there were more but the drive to let them go definitely increased.

 

[Smiter]

I don't know if there were more but the drive to let them go definitely increased.

Now that's the shit I'm talking about. What were you on about hair, aggression and other unmanly things when you should have led with this? Atleast consider your own name here.

 

[Tbagger]

Yep, the enclo from India was actually clomiphene. Not sure about the Chinese sources. The best bet might actually be some online clinic in the states or something like modern aminos or umbrella labs, etc.

I was taking the mislabeled Indian clomid. Messed my hormones all up. I then switched to actual enclomiphene from MA Research but never could quite get to feeling good. My SHBG shot up and tanked my e2. My total test went up a bit but free test dropped. Everything was just messed up and I couldn't dial it in. Felt worse than I did with my natural low t. Threw in the towel and jumped on trt and am annoyed I spent so much money and energy trying to avoid it. I feel AMAZING and will never go back! One of the best decisions I've made for my health and wellbeing.

 

[swimmer]

Now that's the shit I'm talking about. What were you on about hair, aggression and other unmanly things when you should have led with this? Atleast consider your own name here.

I don't know if this is normal or not but this is what they looked like under the microscope!! You think I should see a doctor?

 

[FartfulCodger]

$80 for Enclomiphene Citrate Solution (12.5mg/mL, 50mL) from Chemyo, which I understand is a reputable vendor. It doesn't taste good, but I've been taking 6.25mg (0.5mL) for 10 days without any problems.

 

[Smiter]

I don't know if this is normal or not but this is what they looked like under the microscope!! You think I should see a doctor?

What? why? You got a Xenomorph chestburster in your nuts... thats badass

 

[Smiter]

for 10 days without any problems.

with any benefits though?

 

[FartfulCodger]

with any benefits though?

Haven't noticed anything yet. I think it's too early. Will do a blood test this summer.

 

[Mr. Blonde]

I was taking the mislabeled Indian clomid. Messed my hormones all up. I then switched to actual enclomiphene from MA Research but never could quite get to feeling good. My SHBG shot up and tanked my e2. My total test went up a bit but free test dropped. Everything was just messed up and I couldn't dial it in. Felt worse than I did with my natural low t. Threw in the towel and jumped on trt and am annoyed I spent so much money and energy trying to avoid it. I feel AMAZING and will never go back! One of the best decisions I've made for my health and wellbeing.

Eventually, I might do trt. I'm only 39 and do a lot of traveling. I'm sure with more time, I could come up with more excuses.

 

[JCO79]

Clomid gave me the Clomid Crazies. I am researching Enclomiphene as I am struggling on TRT Test Cyp/Enan with Erythrocytosis. Curious to what you hematocrit is and escpecially if your test levels continue to rise. My hematocrit did not raise nearly as much on Clomid, but I was losing my mind and also concerned about floaters since I was

Dosing more frequently (eg daily or every other day) can help with this. Some people do subcutaneous rather than IM injections to make the frequent injections less difficult to tolerate. Subq has been shown to be equally efficacious.

 

[MTSpace]

I pin daily sub-q but my hematocrit still rises too fast. Will lower dose even more to see if this lever helps.

 

[JCO79]

I pin daily sub-q but my hematocrit still rises too fast. Will lower dose even more to see if this lever helps.

Hopefully lower dosing will be helpful but if not, regular blood donation could help you and others.

 

[MTSpace]

I just did a blood donation and it crashed my ferritin. Sore large joints, sore quads, out of breath easily, restless sleep, and headaches. But all other blood work is great. Now doing iron infusions to get ferritin back to and am sure that will drive up red blood cell production. Vicious cycle as I seem to be sensitive/hyper towards red blood cell production.

 

[Tbagger]

I just did a blood donation and it crashed my ferritin. Sore large joints, sore quads, out of breath easily, restless sleep, and headaches. But all other blood work is great. Now doing iron infusions to get ferritin back to and am sure that will drive up red blood cell production. Vicious cycle as I seem to be sensitive/hyper towards red blood cell production.

What’s your current dose and test level if you don’t mind sharing? Also, are you tracking your water intake?