Eloralintide Dosages

[SoCalGirl]

I've read that L*y created Eloralintide as the new Cagri 2.0 - longer half-life, more stable, etc. It looks like you can dose at 1mg for about 9% body weight loss. Here's a summary I pulled from an NIH study:

The mean percent change in bodyweight from baseline after 48 weeks (efficacy estimand) was:

-9% (1 mg, 95% CI -12·6 to -6·3)

-12% (3 mg, -14·9 to -9·8),

-18% (6 mg, -20·7 to -14·5),

-20% (9 mg, -22·7 to -17·5)

I think I like the 1-3 mg range for myself. Definitely thinking about adding this one to the weekly RETA.

Anyone else jumping into the deep end, early?

 

[Super Trips]

im doing 6mg with 6 mg of reta from the rip

 

[Nopenada]

Anyone else jumping into the deep end, early?

I should have a kit by the end of July and thought I was going to give it a go, but I’m in maintenance on a low dose of Tirz after losing what I was looking to lose on Reta and I think I’m going to start lighter and give Cagri a shot instead. I don’t want to lose any more but I have a hard time controlling what I eat if left to my own devices.

I’ve got a lab rat (friend) that I’ve got on 4mg of Reta to compliment his 10mg of prescription Zepbound, but he still seems a bit stalled. Going to up the Reta again, but if that doesn’t work I’ll be pulling out the Elora to see if we can break his stall.

 

[lessthanhalf]

-9% (1 mg, 95% CI -12·6 to -6·3)

-12% (3 mg, -14·9 to -9·8),

-18% (6 mg, -20·7 to -14·5),

-20% (9 mg, -22·7 to -17·5)

Interesting, given 1mg of reta caused about 9% and 4mg caused about 20% weight loss, I wonder whether they will end up selling a combo elora/reta at low doses for less severe obesity, with hopefully very low rates of side effects, but still pretty good weight loss, and the higher dose versions for more severe obesity with maybe amazing degrees of weight loss. If the effects are truly additive you could get near 50%.

 

[SoCalGirl]

Interesting, given 1mg of reta caused about 9% and 4mg caused about 20% weight loss, I wonder whether they will end up selling a combo elora/reta at low doses for less severe obesity, with hopefully very low rates of side effects, but still pretty good weight loss, and the higher dose versions for more severe obesity with maybe amazing degrees of weight loss. If the effects are truly additive you could get near 50%.

YES YES YES - exactly what I was thinking! They are going to COMBO it with RETA, just like all the new CAGRI+GLP gearing up. I got my order in, pretty excited about this one, because I will combine it with RETA.

 

[lessthanhalf]

I had a look at the eloralintide study and it was quite interesting that at 48 weeks there was no signs of a plateau, weight was still dropping for all doses at that stage so max weight loss for elora is going to be higher than the numbers seen so far. Presumably over the next year or 2 there will be longer or follow up studies that I think will show at least another 5% and maybe even another 10% weight loss. And the animal studies comparing cagrilintide to eloralintide showed more fat mass loss and less muscle loss for elora.