Thanks for posting the study and the graph.
For those considering eloralintide early while it is still expensive, the top right graph says something about that. Elora at 1nmol/kg did nothing much but at 10nmol/kg caused an additional 5% weight loss , where 10 times that dose caused an additional 10% weight loss. While this is not remotely the same as human evidence, it does suggest that the response is not linear with respect to doses. Assuming the high dose is chosen to cause 10% weight loss on its own, and about the same as the dose of tirz used in the study, then 1/10 of that dose still caused an additional 5% weight loss, which suggests that low dose add on elora might work better than expected if it does something similar in humans. And if it could add another 10% to reta's weight loss at higher doses it would be a huge advance, 40% weight loss would be enough to fix anything but the most severe obesity, and even if worse than that still make a huge difference to health if still a bit overweight at the end.
Feel a bit sorry for the poor rats started on 100nmol/kg of elora with tirz , no food intake for nearly a week in a rat is a pretty long time. I cannot imagine that did not come with some side effects, rats don't vomit so it is harder to tell, but it suggests jumping to a high dose of elora suddenly if already on tirz could be most unpleasant, something like a month of no eating presumably with side effects that fit with that. Which to me sounds like good chance of ending up in hospital on a drip. It does suggest considerable care should be taken with doses in those experimenting with elora early, where starting low and going slow is probably essential.
For those considering eloralintide early while it is still expensive, the top right graph says something about that. Elora at 1nmol/kg did nothing much but at 10nmol/kg caused an additional 5% weight loss , where 10 times that dose caused an additional 10% weight loss. While this is not remotely the same as human evidence, it does suggest that the response is not linear with respect to doses. Assuming the high dose is chosen to cause 10% weight loss on its own, and about the same as the dose of tirz used in the study, then 1/10 of that dose still caused an additional 5% weight loss, which suggests that low dose add on elora might work better than expected if it does something similar in humans. And if it could add another 10% to reta's weight loss at higher doses it would be a huge advance, 40% weight loss would be enough to fix anything but the most severe obesity, and even if worse than that still make a huge difference to health if still a bit overweight at the end.
Feel a bit sorry for the poor rats started on 100nmol/kg of elora with tirz , no food intake for nearly a week in a rat is a pretty long time. I cannot imagine that did not come with some side effects, rats don't vomit so it is harder to tell, but it suggests jumping to a high dose of elora suddenly if already on tirz could be most unpleasant, something like a month of no eating presumably with side effects that fit with that. Which to me sounds like good chance of ending up in hospital on a drip. It does suggest considerable care should be taken with doses in those experimenting with elora early, where starting low and going slow is probably essential.
