对于体重在 10-15 磅之间的宝宝，Tirz 值得我考虑吗？

[squig33]

My understanding is that these drugs are created for long term use, and I have read that generally people who need GLP-1 drugs are very likely to need to continue them for long term treatment. This is a very personal decision for everyone. I would not take something like this for short term 10-15lbs but you do you.

From ChatGPT with source links:

Clinical trials investigating tirzepatide, a dual GIP and GLP-1 receptor agonist, have primarily focused on its long-term use for managing type 2 diabetes and obesity. For instance, the SURPASS-4 trial evaluated tirzepatide over a 104-week period, demonstrating sustained reductions in HbA1c and body weight compared to insulin glargine. (Lilly Medical ) Similarly, the SURMOUNT-1 trial assessed tirzepatide's efficacy in weight management over 72 weeks, with findings indicating significant weight loss and a reduced risk of progression to type 2 diabetes. ( Endocrinology Advisor ). Regarding short-term use, data are limited. A follow-up analysis from the SURMOUNT-1 trial noted that 17 weeks after discontinuing tirzepatide, participants experienced modest weight regain and increases in HbA1c levels, suggesting that the benefits of tirzepatide may diminish upon cessation. (Science Daily ) This underscores the potential necessity for ongoing treatment to maintain therapeutic effects.

 

[BrowsingAbout]

Hell yeah, why not? If it makes it easier to achieve your goals, imo I say do it. Fuck anyone else or their opinions. We're only here ~70 years, why struggle harder with anything than you have to? It's such a weird mindset to have. If an easier road is available, i personally think its fucking stupid to not take that. Pride/ego/shame/fear/etc. are the bane of our existence.

I’m with this! DO IT!

 

[BrowsingAbout]

I had 15 stubborn pounds that would not come off - no matter what diet or exercise. I’m also a binge eater and have always had issues with that. My psych suggested a GLP1. I found tirz and lost 20! Happy and healthy!! And SO thankful!

 

[Allfornat]

Why not? I used it to get rid of my 5lb menopausal weight I could not lose working out or eating healthy! It worked!!!!

 

[Dee X]

5'10" at 145 pounds sounds too thin. i'm the same height and at 165 i had people telling me i didn't look good.

it's a very unpopular thing here but, i use fat melting injections to target the areas where the fat might never go away.

i'm guessing your head is going to look too gaunt once you go that low.

I'm at 161 right now, heading down to 150.

What's crazy is that going off of BMI alone, 129 is still within range of healthy. I can't imagine how unhealthy we would look at that weight.

 

[raw_oyster_eater]

I'm at 161 right now, heading down to 150.

What's crazy is that going off of BMI alone, 129 is still within range of healthy. I can't imagine how unhealthy we would look at that weight.

it'd be nice to see some picts of people but there are some who think they have a god given right to steal and alter your photo ( put your head on whatever) if they get mad at you.

 

[Dee X]

it'd be nice to see some picts of people but there are some who think they have a god given right to steal and alter your photo ( put your head on whatever) if they get mad at you.

I'm sorry you had a falling out with your homie.

 

[raw_oyster_eater]

I'm sorry you had a falling out with your homie.

but me and you still love each other so i'm still all good.

 

[AndyPanda]

What were those fat melting injections?

Lemon Bottle

 

[Superfluous]

Lemon Bottle

Where do you get your supply? The wife is interested in this but apparently a lot of fake stuff goes around Europe.

 

[MingHenry]

I gained a lot of weight from antidepressants and college. No longer on antidepressants. Dropped most of it the last 2 years. Went from about 230 peak weight to just recently breaching the 160 mark as a 5’10 dude with some muscle mass.

I know it probably sounds like I am skinny already at that weight, but I would estimate I’m somewhere in the 16% bodyfat range and just look generally unimpressive with a flubby gut and love handles. As I’ve gotten skinnier the weight has gotten more stubborn and I’ve been meticulously calorie tracking and getting 10k steps, but the final 10-15 pounds I’m looking to lose to get shredded has been very difficult.

I eat high protein (150g+ daily), strength train 3-4 times a week, and cardio daily. I don’t doubt I could do it naturally, but I feel like throwing Tirz at it would just make it less of a ‘battle’ as the biggest thing I struggle with is constant hunger, and it just takes a mental and physical toll to try and ignore my body telling me to eat.

Is doing 2.5-5mg for 2ish months to just finish the job and then maintain worth it? I’m no stranger to drugs and biohacking, I’ve messed around with some SARMs and Anavar before. Dealt with the whole mental piece of ordering grey market research chemicals from china and then putting it into my body. More just asking if the peptide itself is practical for this purpose. Anyone else used short term for vanity weight loss/bodybuilding purposes? Should I just suck it up and finish the job naturally?

I think before you start tirz - and I have no issue with how you want to use it, but as people have noted, the weight likely might return if you don't keep using it - maybe look into some other weight loss/metabolism peps - like tesa, tesa/ipa, tesa/ipa/cjc, AOD, also tesofensine, which is a pill. You might get where you want to go without tirz.

 

[超梦]

Thanks everyone for your input, I’ve read and considered everything. Talked with another guy on Reddit who has used glp1 for this exact purpose with great success Ended up ordering a 5mg sema kit and will give it a whirl.

 

[scarywood75]

Hate however you want, but my theory is if you can't lose weight without the med, then you're gonna gain it back once you stop.

It's because you'll slowly adapt back to how you were before. It may not be instant, but you'll slowly start eating more calories and by the time you realize these 15 pounds are back.

Obviously you could just restart the med worse case no big deal, I'm just giving a heads up to what will most likely happen. My advice would be to stay on a low dose forever, but you can definitely try for yourself.

 

[scarywood75]

And no judgment here btw, I took it personally because yeah I could've put more effort toward weight loss and achieve the same without it, but I want to put my efforts in other things on my life, so I picked the easier route for my weight loss.

We are in a era with infinite tools, if you can achieve your goals with less efforts and focus on other areas of your life with GLP1, by all mean go for it!

 

[scarywood75]

I too didn't have much to lose, about 50lb and I'm almost there, it's a tool and not just for people that NEEDS it, but also for those that WANTS it

 

[scarywood75]

When people judge you for going the easier way, remind them that :

- they take their car to go to the grocery that's 5 mins away.

- they job hopping for a better pay

- they buy your vegetables instead of growing them

- so on.

Trust me they get quiet pretty quick lol

 

[hexagonal]

I gained a lot of weight from antidepressants and college. No longer on antidepressants. Dropped most of it the last 2 years. Went from about 230 peak weight to just recently breaching the 160 mark as a 5’10 dude with some muscle mass.

I know it probably sounds like I am skinny already at that weight, but I would estimate I’m somewhere in the 16% bodyfat range and just look generally unimpressive with a flubby gut and love handles. As I’ve gotten skinnier the weight has gotten more stubborn and I’ve been meticulously calorie tracking and getting 10k steps, but the final 10-15 pounds I’m looking to lose to get shredded has been very difficult.

I eat high protein (150g+ daily), strength train 3-4 times a week, and cardio daily. I don’t doubt I could do it naturally, but I feel like throwing Tirz at it would just make it less of a ‘battle’ as the biggest thing I struggle with is constant hunger, and it just takes a mental and physical toll to try and ignore my body telling me to eat.

Is doing 2.5-5mg for 2ish months to just finish the job and then maintain worth it? I’m no stranger to drugs and biohacking, I’ve messed around with some SARMs and Anavar before. Dealt with the whole mental piece of ordering grey market research chemicals from china and then putting it into my body. More just asking if the peptide itself is practical for this purpose. Anyone else used short term for vanity weight loss/bodybuilding purposes? Should I just suck it up and finish the job naturally?

Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies

Objective To quantify the association of indices of central obesity, including waist circumference, hip circumference, thigh circumference, waist-to-hip ratio, waist-to-height ratio, waist-to-thigh ratio, body adiposity index, and A body shape index, with the risk of all cause mortality in the...

www.bmj.com

Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies - PubMed

PROSPERO (CRD42021240743).

pubmed.ncbi.nlm.nih.gov

From a health perspective, you're already where you need to be if you're indeed at 16% bodyfat - all cause mortality doesn't start increasing until the mid 20%s for men. (There's actually a J shaped curve where continuing to drop bf% increases all cause mortality risk but this is likely confounded by people that have very low bf% due to disease skewing the risk)

 

[zpped]

Hate however you want, but my theory is if you can't lose weight without the med, then you're gonna gain it back once you stop.

It's because you'll slowly adapt back to how you were before. It may not be instant, but you'll slowly start eating more calories and by the time you realize these 15 pounds are back.

Obviously you could just restart the med worse case no big deal, I'm just giving a heads up to what will most likely happen. My advice would be to stay on a low dose forever, but you can definitely try for yourself.

The vast majority of people that lose weight with any method gain it back.

 

[scarywood75]

The vast majority of people that lose weight with any method gain it back.

Yeah spot on

 

[hexagonal]

看完帖子后面的内容：

我觉得你已经下定决心，会按你的想法去做。这没问题。你是成年人，所以有权自己做决定。

但是……估算体脂率并不十分准确。大多数测量方法都不太准确。真正准确的只有医学影像——CT 和 MRI。双能 X 射线吸收法 (DEXA) 扫描的准确度在不同个体之间仍然存在高达 10% 的波动，不过在大样本人群中误差会降低，所以它仍然适用于研究。即便如此，它仍然比估算要准确得多，所以如果你想更清楚地了解自己的体脂率，我强烈建议你去做一次 DEXA 扫描。即使是照片也提供不了太多信息——每个人的脂肪分布都不一样，所以很难从中得出确切的结论。

接下来我要说的可能有点冒险，你们可以随便骂我：我不认为减掉10-15磅就能让你拥有理想的身材，尤其是在你体脂率16%的情况下。很多人在体脂率十几磅的时候就开始增肌，而且体脂率越接近10%，就越有可能影响你的睾酮、皮质醇、能量水平等等，从而对肌肉增长产生负面影响。有些人体脂率低于10%才会出现这些症状，有些人则低于15%才会出现。鉴于你目前的热量缺口很大，很难判断你整体的增肌潜力，所以我建议你尝试体脂重组，甚至从你现在的体脂率开始增肌——你正处于增肌潜力最佳的范围内。虽然这个过程不会像从10%体脂率开始缓慢增肌那样迅速达到理想体型，但如果你发现增肌速度不如预期，这种方法可以排除更多干扰因素。而且，增加几磅肌肉并不会对燃烧卡路里产生翻天覆地的影响，但确实能带来一些提升，或许能让你更容易达到理想的体脂率。