Drugs for reta side effects

[FlowerFairy]

I'm sure you use a toothpaste tube as directed but how can you say something is dangerous if you never had a human actually do it and see for itself.

research is not for everyone but the most brilliant minds ever did self testing

take Alexander Shulgin and Ann Shulgin for example they made the most advanced chemical discoveries of the 20th century.

Except humans HAVE done this before, and gotten sick as heck. This is reckless and not smart.

 

[diogenes]

Have you actually researched the titration schedules out there? This is like the 4th post I’ve seen of reckless and dangerous titrations on Reta….these medications can be extremely dangerous if you blow in there so quick. Everyone is different and requires different doses to feel the desired effects but damn. You’re being reckless bro

I prefer the term "aggressive," but yes I'm aware the phase 2 trials started at much lower doses. I'll give it a rest for a bit and restart more gently.

 

[Calm Logic]

Gabapentin is used for neuropathic pain and seizures; the pathway it works along does not induce sleep.

From a small study:

Gabapentin increases brain concentrations of γ-amino-butyric acid (GABA) and decreases glutamatergic activity...

After at least 4 weeks of abstinence, alcoholic patients with persistent insomnia reported significant sleep improvement during treatment with either gabapentin or trazodone. Although the overall sleep of each medication group improved significantly over time, patients who received gabapentin improved significantly more than did patients who received trazodone. At follow up, gabapentin-treated patients were less likely than trazodone-treated patients to have initial insomnia and to awaken in the morning feeling tired and worn out. Both gabapentin and trazodone were well tolerated as indicated by low dropout rates that did not differ significantly between the two groups. All dropouts occurred after the first dose of medication because of morning drowsiness.

 

[FlowerFairy]

From a small study :

Yes. ALCOHOLICS.

 

[Calm Logic]

Drowsiness is listed as a side effect, so it's not surprising to me that gabapentin can help with sleep, especially since some people discontinue gabapentin due to daytime drowsiness. A meta-analysis.

 

[FlowerFairy]

Drowsiness is listed as a side effect, so it's not surprising to me that gabapentin can help with sleep, especially since some people discontinue gabapentin due to daytime drowsiness. A meta-analysis .

Yes, but a side effect is something that might happen. Additionally you have to consider the end user. This one has already demonstrated that he is lacking in common sense. If he takes one capsule and it doesn’t make him sleepy, by his own logic he should triple the dose. Harm reduction is the goal.

 

[DR.D.]

On Friday morning I injected 6mg of retatrutide subcutaneously in my thigh. This is up from 4mg the previous week, and 2 mg the week before that.

I felt nothing on Friday

My appetite was mildly suppressed on Saturday

It was more suppressed Sunday and Monday (today), so great

Unfortunately it's been very difficult to sleep, and my skin feels sensitive and even painful all over. I've been wondering what drugs I might take to help with this. I have lying around some propranolol, gabapentin, and clonidine, all of which I've been prescribed for other things but do not currently take. Might any of these help?

I take just a 1/4 dose of a cardio selective beta blocker and it seems to help. Same thing if stacking with T3 or T4. Its hard to sleep when your pulse rate is though the roof!

If you like natural, a few Hawthorn Berry capsules can be surprisingly effective as well.

 

[Calm Logic]

I would rely more on marijuana gummies anyway, not to mention the Benadryl.

 

[FlowerFairy]

I would rely more on marijuana gummies anyway, not to mention the Benadryl.

Same. Gabapentin is what I give my 16 yo dog for pain. Benadryl and MJ gummies are more effective for sleep. Mushroom gummies are pretty relaxing too.

 

[PackmanJohnny]

Yes, but a side effect is something that might happen. Additionally you have to consider the end user. This one has already demonstrated that he is lacking in common sense. If he takes one capsule and it doesn’t make him sleepy, by his own logic he should triple the dose. Harm reduction is the goal.

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.

 

[zpped]

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.

I think you're confused about what harm reduction means. The purpose of this forum is harm reduction. We all take risks, but encouraging reckless behavior won't be tolerated. That kind of dose escalation can easily put someone in the hospital or worse.

 

[PackmanJohnny]

I think you're confused about what harm reduction means. The purpose of this forum is harm reduction. We all take risks, but encouraging reckless behavior won't be tolerated. That kind of dose escalation can easily put someone in the hospital or worse.

Yeah I totally could be conflating Harm reduction with Harm avoidance(Risk aversion? I need sleep, finals week).

I've been that kid running 400mgs of DNP because the info sources I had access to were not good, a large percent of people in this space become a lot more careful after they touch the stove once or twice and thats just how they learned. When you know better, you do better.

Hopefully he gleans some info and gets himself educated. I've never really thought about the consequences of OD'ing on GLPs, because that would require some TENACIOUS stupidity, but the deeper I get into this world I do find that bar creeping lower and lower.

 

[peptidepower77]

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.

What's wrong with pinning subq in your thigh? That's a pretty standard place on the Mounjaro docs, for testosterone replacement etc.

 

[PackmanJohnny]

What's wrong with pinning subq in your thigh? That's a pretty standard place on the Mounjaro docs, for testosterone replacement etc.

I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.

 

[peptidepower77]

I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.

I don't see why, my thigh has plenty of skin + fat on it. Regardless, subq is only supposed to break through to just under the final layer of the skin. It's why most subq needles are only 5mm. If you're using a 8-12mm needle that you brought mistakenly I can see it maybe hurting. But for even practical reasons (like being better able to visualize where I'm going to pin it), my thighs are way easier than my stomach for me. Lots of people report less side effects as well (I haven't experienced that), but that could just be placebo so who knows.

 

[Rated_rko]

Melatonin for sleep

Fibre for washroom

And betaine for backed up

 

[zpped]

I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.

Thigh is usually not recommended for IM anymore because ventroglute and lateral delt are so much better. But its fine for subQ, especially if you're not very lean.

 

[diogenes]

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.

Much of it isn't responsive to my actual question, but what is seems pretty good, and I'm grateful for it.

I don't appreciate the contemptuous, peacocking digressions, kind of like Linux USENET in the late '90s ("RTFM!!1"; "n00b!!"). I rarely post on forums, and I'd hoped the culture had matured. Apparently not.

As far as I've read, subq injection into the anterolateral thigh is fine, especially with a fatty thigh, as I have. Nothing I can find in published protocols for GLP-1 drugs mandates a specific injection site. Papers report that some patients prefer the thigh, with no shade cast on this site. From what sources I can find, thigh might yield slightly less/slower availability than abdomen, but the difference is regarded as insignificant.

If there are sources I've missed that indicate otherwise, I'd be curious to learn about them and change my injection site accordingly.

 

[diogenes]

I take just a 1/4 dose of a cardio selective beta blocker and it seems to help. Same thing if stacking with T3 or T4. Its hard to sleep when your pulse rate is though the roof!

If you like natural, a few Hawthorn Berry capsules can be surprisingly effective as well.

Interestingly, my resting heart rate wasn't higher than normal, even when I was most agitated. Still, if I ever experience elevated heart rate, I'll consider atenolol, of which I happen to have some. Thanks!

 

[DR.D.]

Interestingly, my resting heart rate wasn't higher than normal, even when I was most agitated. Still, if I ever experience elevated heart rate, I'll consider atenolol, of which I happen to have some. Thanks!

Yes sir, same one I choose also. 12.5mg is all it takes for me to take the edge off, and I just take it situationally, maybe once or twice a week as needed.