Down 40lbs in 2 months

[GuLPing]

-BEGIN RANT-

In your case- that’s very surprising. I should think any PCP would be up to date with at least the up and coming drugs that handle treating the #1 health concern in USA! (Metabolic syndrome) First off, GLP-1 class medications are not just for weight. They treat a HOST of health problems related to hormone imbalances; Second, Retatrutide is head and shoulders above any other GLP-1/GIP med currently approved.

-END RANT-

No GP is ever going to encourage you or condone taking drugs that are still in testing. FYI, 2/3 of drugs fail in phase 2. Everyone, myself included, is taking a health risk by taking a drug that's not approved ANYWHERE. There are 8000 drugs in clinical trials and several times that in pre-development. No, a GP isn't going to keep track of that nor should they.

Retatrutide seems more effective, but it may turn out to be bad to take weight off that quickly. Tirzepatide, which is approved, is VERY effective especially when combined with some activity. A doctor will tell you to lose weight slowly, consume protein and do weight bearing exercises. They would also suggest losing weight slowly (1-2 lbs a week).

The concern that doctors have in this weight loss is loss of muscle mass and irreplaceable bone loss plus there's a potential rebound effect from metabolic adaptation.

 

[deleted.user.18]

No GP is ever going to encourage you or condone taking drugs that are still in testing. FYI, 2/3 of drugs fail in phase 2. Everyone, myself included, is taking a health risk by taking a drug that's not approved ANYWHERE. There are 8000 drugs in clinical trials and several times that in pre-development. No, a GP isn't going to keep track of that nor should they.

Retatrutide seems more effective, but it may turn out to be bad to take weight off that quickly. Tirzepatide, which is approved, is VERY effective especially when combined with some activity. A doctor will tell you to lose weight slowly, consume protein and do weight bearing exercises. They would also suggest losing weight slowly (1-2 lbs a week).

The concern that doctors have in this weight loss is loss of muscle mass and irreplaceable bone loss plus there's a potential rebound effect from metabolic adaptation.

Doctors have a responsibility to stay current with evidence-based practice. Medical knowledge changes fast, and a license alone doesn’t guarantee competence. A doctor can graduate at the bottom of their class, never update their understanding, and still practice and call themselves doctors. That should concern you. Better healthcare depends on holding your doctor accountable for ongoing education and genuine engagement with emerging data.

Weight-management science shows the same pattern across all standard-of-care programs: people lose both fat and lean tissue, including bone mineral content. This has been documented for decades in metabolic ward studies and in modern trials of calorie restriction, meal-replacement programs, bariatric surgery, and lifestyle-based interventions published in journals like The Journal of Clinical Endocrinology & Metabolism, Obesity, and The American Journal of Clinical Nutrition.

GLP-1-based medications have not shown abnormal or pathological lean mass loss. When you adjust for total weight loss, the proportion of lean mass lost matches what you see in conventional dieting. The key problem isn’t the medication; it’s the biology of weight cycling. When people regain weight without structured intervention, the regain tends to come back as mostly fat. When they lose weight, about three-quarters of the reduction comes from fat and the rest from lean tissue. That physiological pattern existed long before GLP-1 drugs.

This is why protein intake and resistance training matter. Studies on weight-loss preservation consistently show that adequate dietary protein and progressive strength training reduce lean-tissue loss and improve functional outcomes. These findings appear across trials in Sports Medicine, Nutrition Reviews, and Obesity Reviews.

If you expect competent guidance through this grey market terrain, you need a clinician who has an open mind that you can be honest with, actually keeps up with the literature and understands how to apply it. That’s not asking too much. It’s the baseline you deserve.

 

[4StrandKnot]

Welcome! It's encouraging to me to hear about how you were able to get off Lisinopril. I have been on it for a couple of years due to my age (50s), obesity, and blood pressure. Plus, hypertension runs in the family. It's had some benefit, it has an anti-inflammatory effect that has been favorable. I'm not stiff in the morning.

But, I would like to get my weight and BP to a point where I don't need it. Even with family history working against me, I'm not giving up on that goal.

 

[GuLPing]

ed practice. Medical knowledge changes fast, and a license alone doesn’t guarantee competence. A doctor can graduate at the bottom of their class, never update their understanding, and still practice and call themselves doctors. That should concern you. Better healthcare depends on holding your doctor accountable for ongoing education and genuine engagement with emergi

That's not remotely true. Doctors do keep up with changes. Doctors can't practice without being licensed and that licensure has very specific education requirements that are ongoing. Why are you speaking about things that you don't have knowledge of?

Mainstream doctors will point you towards drugs that have actually been approved by the FDA. That might bother you, but they're medical professionals doing their job. Given that you don't know how credentialing even works, you might want to avoid talking about the medical profession.

 

[ZippityDooDah]

Why are you speaking about things that you don't have knowledge of?

The attitude is not welcome here. You can disagree without being disagreeable (pretty sure that's one of the first few rules of the forum, maybe even the very first one...).

That's not remotely true.

I respectfully disagree with your premise that anything in deleted.user.18s' quoted text can't be remotely true (see how easy that was?).

Let's consider the issues raised as a True or False quiz/questionnaire (ironically I just replied to an unrelated post regarding boolean searches ), and analyze anything you (or anyone else who would like to participate) determine cannot be remotely true:

1. Doctors have a responsibility to stay current with evidence-based practice.

True or False?

2. Medical knowledge changes fast, and a license alone doesn’t guarantee competence.

True or False?

3. A doctor can graduate at the bottom of their class, never update their understanding, and still practice and call themselves doctors.

True or False?

4. Better healthcare depends on holding your doctor accountable for ongoing education and genuine engagement with emerging data.

True or False?

 

[deleted.user.18]

That's not remotely true. Doctors do keep up with changes. Doctors can't practice without being licensed and that licensure has very specific education requirements that are ongoing. Why are you speaking about things that you don't have knowledge of?

Mainstream doctors will point you towards drugs that have actually been approved by the FDA. That might bother you, but they're medical professionals doing their job. Given that you don't know how credentialing even works, you might want to avoid talking about the medical profession.

Have you seen what passes for CME?! Total joke. Married to one, so I know what’s required. There are a lot of bad Drs out there slacking off on keeping up with the science.

 

[RuggerPanda]

Congrats on the weight loss so far! I've purchased 3 time from Jeep and has always been good. I think it's great you told your doctor and they were willing to look into Reta. Too many people feel like they need to hide this from your doctor, my doctor is aware of the peptides that I take. Just don't feel like you have to keep increasing your dosage if your having good results at your current level and good luck on the continued weight loss.

 

[Hichewgoddess]

Have you seen what passes for CME?! Total joke. Married to one, so I know what’s required. There are a lot of bad Drs out there slacking off on keeping up with the science.

As a licensed health care provider that is required to get continuing education, I agree. There’s many “stress relief activities for your office team” and “yoga for providers” classes out there that count towards yearly credits. Not all doctors are taking the cutting edge courses.

 

[deleted.user.18]

As a licensed health care provider that is required to get continuing education, I agree. There’s many “stress relief activities for your office team” and “yoga for providers” classes out there that count towards yearly credits. Not all doctors are taking the cutting edge courses.

…and it is unfair of me to let it go at that. Because there are A LOT of providers who DO keep up at least with their specialty if not broadly. I just know that if my wife chose to she could do retreats to the Caribbean and sleep through the seminars hung over and still get her CME credit… if she didn’t take her practice seriously. Also, I grew up with a family doc who did keep up to a degree, but refused to leave his comfort zone of OG protocols. We owe it to ourselves to find the good ones and support their practice where possible. As with most endeavors in life we don’t get to abdicate responsibility for our health. Advocate, educate, and participate.

 

[Retarage]

yeah, it’s quite unbelievable.

I started with 15mg Reta from a website called muscle shop. My friend has been juicing for a long time and he put me onto the site for Reta. I am now on a 20mg vial from Apex Peptides and I’m awaiting my first grey market shipment from JEEP.

The Journey: I started at about 325. After the first week on Reta (1mg), the only thing I noticed was getting full super fast. It was absurd. 2 rolls at Texas Roadhouse, 2 sweet teas, and I couldn’t even eat my entree a few days after my dose.

I then went up to 2mg a week later. On that same day, I saw my doctor and got my blood work done. My BP was also high which has nothing to do with Reta. I was completely honest with her about the drug I’m on (Reta) and she did a little research and told me it just looks like a GLP-1 to her. Everything came back fine with my blood work except my vitamin D which has always been low and my cholesterol was a little high. Both of these are not due to reta. I was prescribed lisonipril for my blood pressure and given a sheet to log my weight and blood pressure daily for two weeks. This is when I saw the fat just melting off my body.

After the 2mg, I felt nauseous next day. But to me, I liked that feeling. It wasn’t too bad. It was just enough nausea to force myself to eat with I liked. After this, I found myself ordering Wendy’s and throwing away half my burger and just feeling sick of it.

I stayed on 2mg for a few weeks then went up to 4 which I’m on currently. I believe I will be upping to 5 soon. I also feel like that after some time stored, reta becomes less strong. People say 21-28 days refrigerated but to me it’s a lot stronger when I first constitute it.

I am now 284 as of two days ago. I had to stop taking my lisonopril because I was starting to almost faint when I’d stand up. My guess is, dropping 40lbs lowered my blood pressure naturally.

My biology

For starters, I’m 24. I go to the gym often. I’m not 284lbs of fat but I’m also not lean by any means. My job is semi active.

Thanks for this post! Good ideal starting at 1 mg! I’m still researching and waiting to decide to order my fist batch from but think I’ll start with 1mg the first week. Did you send any to be third party tested?

 

[MFGamesta]

Great job! I would only suggest not to rush it. Just because you stall for a few days doesn't mean you need to immediately titrate up. Be patient. Since you have blood sugar issues, you could get a constant glucose monitor (CGM) off amazon for 100 bucks for 2 and they last 2 weeks. It's great for seeing where you're at and you can see what foods spike your glucose. For example when I have my morning cup of coffee with cream and a teaspoon of sugar, my glucose doesn't even go up so I don't worry about that. But one pop-tart sent my blood sugar from 70 to 180 in minutes!

 

[HereKittyKitty]

That's some unbelievable weight loss in 2 months. Your BP is so much better! Glad you found your way here. Lots of great information. I'm learning a lot.

Keep working on hydration. It's critical.

 

[BNLFL]

Glad the BP is better, and awesome on the weight loss. You can grab a inexpensive BP cuff that goes on your wrist from Amazon. I got one a little over 3 years ago when I got out of 3 weeks in the hospital. It always damn close to my cardiologists when I go.