I’m assuming you mean you don’t feel the hunger suppression as much on once a week? And that you feel better suppression spreading it out?
If so, yes, many split-dose for a number of reasons, this is one of them. The only “downside” that we are aware of at this point, is that your peak level will be lower (but more sustained at a moderate level). Personally I don’t consider it a downside, but everyone is different. If it works for you, go for it.
Other arguments might be the hassle of remembering more than 1x/week- but IMO, the benefits far outweigh any known potential downsides.