Deep Sleep Peptides

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Speaking of Tesamorelin, my data suggests it could affect my REM duration and overnight HRV negatively. It is something I also heard on Huberman's episode on peptides.
 
MingHenry said:
DSIP, EPI, KPV, Ta-1/Thymulin.

For tough sleep issues, insomnia, circadian rhythm disruption etc, often the short, low mcg protocols won't be of much help. Longer protocols and higher dosing are usually more effective. I have all those sleep issues.

I started with DSIP, settled around 200mcg-300mcg, taken a couple of hours before I want to sleep, has helped me get much deeper sleep, but DSIP won't help get you to sleep faster. I used it nightly for 3 months, and will cycle back onto it when I need it.

A week after I began DSIP, I started EPI, and started there at 300mcg, went as high as 1mg over the course of 3 months, but 300-500mcg was the right dosing for me. With Epi, I tried it first mid-day, some it energizes, some it makes tired. It energized me, so I took it in the AM until I no longer felt it energizing me and moved it to PM, usually an hour or so after DSIP.

When I cycled off DSIP, I kept the Epi and added in KPV - lots of benefits with that pep, as with Epi, and I like that combo a lot.

When I cycled off Epi recently, I kept the KPV and when I finish my current vial, I will be trying Pinealon and either DSIP or another pep I am forgetting.

I also mixed what I call the KPV Glow - I didn't much like KPV in the ghk-cu/bpc-157/tb500(4) in part b/c the KPV and BPC-157 are in ways duplicative, but I do like the new vial I blended of ghk-cu, GHK Basic, KPV. And use that early evening. Helps as well with my sleep.

Over the course of the 3 months, I find I'm actually getting tired earlier, and my sleep anxiety has largely abated, and I'm falling instantly and deeply asleep. Even if I wake during the night, which I usually do, I'm able to fall back to sleep either instantly or within a very short time, when before I'd be up for hours.

Yesterday, to avoid getting sick I decided to start an immunity protocol of TA-1/Thymulin which runs 10-14 days, TA-1 1.5mg and THY 1mg nightly. Pinned separately. I slept very well last night using those and eager to see if it holds true tonight
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The more reading I do, I am finding "longer " protocols are better. A positive impact on sleep may not be noticed for days or even weeks. Peps that help sleep don't work like sedatives so you may not notice any change in sleep the day or night you take them; admittedly this was my expectation! They build up in the system and makes changes over time.

People report taking Dsip on a Monday with improved sleep Wednesday-Friday. (I don't have the source readily available)

I've run Dsip, Pinelaon, Epithalon, ipa/cjc.

Falling asleep and staying asleep has been an issue for me for years and the older I get, the more challenging it becomes; which is unfortunate as "repair" is essential to good physical and mental health.

Initially I quit Dsip expecting quick results, but I'm back on a regular daily schedule.

It energizes me, so I take it in the morning. I have both sub q and IN. It's only been a week; nothing to report.

Epitalon; running the 10 day a month protocol. Didn't notice any effect until day 6. My body became "naturally" tired around 8:30pm - which never happens so some changes are occurring; what I can't say.

I ran Pinealon alone but not very long. It energizes me so I take it early.

It does not "induce" sleep however, I felt more refreshed when I wake. Once I finish my Dsip study, I will go back to running a full Pinealon protocol. Stimulates the pineal gland to make melatonin among other things. I'm encouraged by what I'm finding about Pinealon.

The only combo I've tried that "induces" sleep is ipa/cjc no dac. I'm doing that 5 day on 2 off protocol. It definitely works.

Edit:: final mention :: Selank is great to help induce sleep as well. I use selank and semax "as needed ".
 
Valerie said:
The more reading I do, I am finding "longer " protocols are better. A positive impact on sleep may not be noticed for days or even weeks. Peps that help sleep don't work like sedatives so you may not notice any change in sleep the day or night you take them; admittedly this was my expectation! They build up in the system and makes changes over time.

People report taking Dsip on a Monday with improved sleep Wednesday-Friday. (I don't have the source readily available)

I've run Dsip, Pinelaon, Epithalon, ipa/cjc.

Falling asleep and staying asleep has been an issue for me for years and the older I get, the more challenging it becomes; which is unfortunate as "repair" is essential to good physical and mental health.

Initially I quit Dsip expecting quick results, but I'm back on a regular daily schedule.

It energizes me, so I take it in the morning. I have both sub q and IN. It's only been a week; nothing to report.

Epitalon; running the 10 day a month protocol. Didn't notice any effect until day 6. My body became "naturally" tired around 8:30pm - which never happens so some changes are occurring; what I can't say.

I ran Pinealon alone but not very long. It energizes me so I take it early.

It does not "induce" sleep however, I felt more refreshed when I wake. Once I finish my Dsip study, I will go back to running a full Pinealon protocol. Stimulates the pineal gland to make melatonin among other things. I'm encouraged by what I'm finding about Pinealon.

The only combo I've tried that "induces" sleep is ipa/cjc no dac. I'm doing that 5 day on 2 off protocol. It definitely works.

Edit:: final mention :: Selank is great to help induce sleep as well. I use selank and semax "as needed ".
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This is such a good reply! I will be looking all of those up your experiences are great to read about.
 
squig33 said:
This is such a good reply! I will be looking all of those up your experiences are great to read about.
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Thank you! Feel free to dm me anytime if you have any questions 🙂
 
Found this really helpful! I struggle with falling asleep, and then with 2 kids, deep sleep is harder to achieve.
 
Valerie said:
The more reading I do, I am finding "longer " protocols are better. A positive impact on sleep may not be noticed for days or even weeks. Peps that help sleep don't work like sedatives so you may not notice any change in sleep the day or night you take them; admittedly this was my expectation! They build up in the system and makes changes over time.

People report taking Dsip on a Monday with improved sleep Wednesday-Friday. (I don't have the source readily available)

I've run Dsip, Pinelaon, Epithalon, ipa/cjc.

Falling asleep and staying asleep has been an issue for me for years and the older I get, the more challenging it becomes; which is unfortunate as "repair" is essential to good physical and mental health.

Initially I quit Dsip expecting quick results, but I'm back on a regular daily schedule.

It energizes me, so I take it in the morning. I have both sub q and IN. It's only been a week; nothing to report.

Epitalon; running the 10 day a month protocol. Didn't notice any effect until day 6. My body became "naturally" tired around 8:30pm - which never happens so some changes are occurring; what I can't say.

I ran Pinealon alone but not very long. It energizes me so I take it early.

It does not "induce" sleep however, I felt more refreshed when I wake. Once I finish my Dsip study, I will go back to running a full Pinealon protocol. Stimulates the pineal gland to make melatonin among other things. I'm encouraged by what I'm finding about Pinealon.

The only combo I've tried that "induces" sleep is ipa/cjc no dac. I'm doing that 5 day on 2 off protocol. It definitely works.

Edit:: final mention :: Selank is great to help induce sleep as well. I use selank and semax "as needed ".
Click to expand...
Are there any biomarkers you are tracking like IGF-1 or other labs related to these as you test?

I am thinking of running a Tesa/IPA cycle. When did you dose for IPA? Before bed?
 
For me, only Selank, passionflower and Magnolia Bark (Relora) supplements have helped induce sleep. But if taken daily, they don’t seem effective at all.

Other than Magnesium, I believe anything we take for sleep should be cycled.
 
squig33 said:
Are there any biomarkers you are tracking like IGF-1 or other labs related to these as you test?

I am thinking of running a Tesa/IPA cycle. When did you dose for IPA? Before bed?
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I have not tracked bio markers or taken labs.

Ipa cjc is taken 2 hrs after eating before bed and no food 30min afterwards. Drowsy within 10 minutes, no next day hangover.
 
I've tried DSIP twice (as in two vials) since I specifically don't get enough deep sleep and it does very little for me. I recently started taking CJC (no DAC)+ Ipamorelin and I definitely find this helps me sleep better. I'm not sure if I'm actually getting more deep sleep, but I wake up less during the night and find myself being woken up by my alarm in the morning (vs lying awake waiting for my alarm to go off.)
 
I have recently been testing DSIP and have been terribly sleepy the entire next day

Does this improve over time? Im considering abandoning the test
 
TRS123 said:
I have recently been testing DSIP and have been terribly sleepy the entire next day

Does this improve over time? Im considering abandoning the test
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How much has your RS been dosing?
 
TRS123 said:
I have recently been testing DSIP and have been terribly sleepy the entire next day

Does this improve over time? Im considering abandoning the test
Click to expand...
Recently started testing DSIP + Selank intranasal and have had better deep sleep and so far woken refreshed. But you and I are not the same and like I said this is recent so I shouldn't be used as an example yet.
 
RS started at 100mcg up to 150 now. sleep seems deeper but just tired all day and slight headache
 
I have used DSIP, Epitalon, and Sermorelin. None did anything for my sleep. GABA, L-theanine, L-Tryptophan and 5-HTP all work at giving me deeper sleep, according to my Oura ring. The Peps didn't change anything.
 
Peptoidian said:
I've tried DSIP twice (as in two vials) since I specifically don't get enough deep sleep and it does very little for me. I recently started taking CJC (no DAC)+ Ipamorelin and I definitely find this helps me sleep better. I'm not sure if I'm actually getting more deep sleep, but I wake up less during the night and find myself being woken up by my alarm in the morning (vs lying awake waiting for my alarm to go off.)
Click to expand...
Dsip alone I didn't have any change in sleep. I ran Epithalon for 10 days and then added Dsip. Deep sleep and total time asleep increased. Neither induced sleep; they had opposite effect for me. They both had stimulant effects ; short lived; 10-15 minutes. I moved both to earlier in the day; 4pm and 6pm.

Epithalon took at least 7 days to notice any improvement. Effect was getting sleepy on my own - which has always been a challenge. My brain takes time to shut down at night.

Dosing was 200-400mcg for both. I ran them for 30 days.

Sleep quality measured from Apple Watch and sleep app. I take 30 days off and run it again.

I've tried selank sub q early eve to help induce sleep/relaxation. I've found IN more effective for me. Sub q 150-200mcg made me very tired and extremely irritable. 😠Not fun before bed 🫤
 
an Epitalon cycle worked great for me, 20 day cycle. After that CJC/no dac. And magnesium at night.
 
DSIP but has to be IV administered, I did it once, it worked relatively same as first time melatonin oral, then I woke up to reality and I realised it is too much of a gamble with my health to create a habit and went back to sleeping pills. IV injecting a compound from an underground lab with 0 oversight is pushing your luck too far
 
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