So where do we stand on the possibility of cagri causing Alzheimer's and other negative long term affects? I've only been able to find a post about a post and Google tells me nothing. Any links I can read?
Current thoughts on cagri and Alzheimer's?
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It is being researched to treat Alzheimer’s in addition to diabetes and obesity.Wellwell said:
An amylin analog used as a challenge test for Alzheimer's disease - PMC
Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single ...
pmc.ncbi.nlm.nih.gov
I recently ordered a 10mg kit from SRY, because I am willing to take the risk and have not seen anything other than conjecture on here and another forum that discusses the whole brain/blood barrier drama. That drama was blown out of proportion by non-experts. Nobody has anything solid to support their claims.
Now, none of us that I am aware of have a PhD in Pharmacology or Biochemistry, especially myself. We are all taking risks with a lot of these peptides. Some have not even had in depth studies conducted in humans. I think this is no more dangerous than other substances we are putting into our bodies that actually have evidence of strong negative side effects. For example, the HGH and GHRH peptides that can accelerate tumor growth.
The concern might be around fibrils/oligomers.
If so, we've got a few threads on here but nothing definitive. We were waiting to see what the deal was with the pH on the single chamber cagrisema pen, but I don't think we've had any news there in a while.
If so, we've got a few threads on here but nothing definitive. We were waiting to see what the deal was with the pH on the single chamber cagrisema pen, but I don't think we've had any news there in a while.
AndyPanda said:
I don't think you need a PhD to figure out that Cagrilintide is not the drug they're testing in your citation. Reading comprehension might be helpful, however.
Pramlintide and cagrilintide are different, though they both relate to amylin , a hormone involved in glucose control and appetite regulation
Pramlintide isn't Cagrilintide. Pramlintide is FDA approved. Cagrilintide is not.
The question shouldn't be "does cagri cause Alzheimer's?". The question should be is black market Cagri as safe as the product in FDA trials?
Who's to say black market Cagri has more or less of a propensity to tangle and turn into fibrils and oligomers than the real trial drug?
Wellwell said:
If you really want to read the FUD about oligomers and fibrils... Read this thread.
[archived internal link]
Post in thread 'In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)'
Dec 1, 2024
Fibrils are of secondary importance in this discussion. You could almost leave them out of it.brentm said:
The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.
And yes, they subjected many different amylin analogues to mechanical stress to see which ones...
secretweapon
SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."
pH 7.5 is neutral and around our body's pH.
So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?
I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..
I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.
So take comfort in that.
Fibrils are of secondary importance in this discussion. You could almost leave them out of it.brentm said:
The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.
And yes, they subjected many different amylin analogues to mechanical stress to see which ones...
secretweapon
SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."
pH 7.5 is neutral and around our body's pH.
So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?
I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..
I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.
So take comfort in that.
Click to expand...
It's a shame none of us will get to see our own autopsies. That would be really cool.
Isn't that what they're sold for from the dealership?chmuse said:
(this is not political. i've hated teslas ever since i sat in a model s back in 2013 and thought the interior was shittier than car's half their price)
hexagonal said:
brentm said:
[Imported image pending local asset: attachments-1744209493210-gif.6331]
You, @chmuse, are the palate cleanser in the overly heavy, cloyingly rich, too many courses dinner that sometimes is this forum!chmuse said:
Also, before any of the heavy handed guys points out this is an old thread--I KNOW!!
I was looking up info on cagri.
I was looking up info on cagri.
This is an informational thread, it's worth reviving! It's the stupid drama ones we shouldn't revive, imo.StonePny said:
Side note: never made it over .08 cagri, gave up. Didn't break the stall and didn't seem more effective on appetite than sema alone other than making me ill. I ate about the same amount with sema willpower without needing the added nausea.
I think this sums it up and is where I'm landing. I'm out of MOTS--that I was liking-- coming from 2 sources (one lost in the mail, one floating in pergatory) and i guess I was looking for something else to inject.chmuse said:
As to which course her dosages compare? More like an amuse bouche!StonePny said:
tag @chmuse crypto doser
This didn't age well...chmuse said:
(Your's is the totaled one on the side of the street
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