从蒂尔兹到雷塔的探测进展并不顺利。

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randompersonrandom said:
I keep looking at that--if my last dose of 8.8 was 3-16, and I was at steady state, then the amount still in me today should be 0.66 mg. That's close enough to "gone" that I feel like it's safe at this point to say "ok, this is how I feel on this dose of reta."

I'm really glad I never scoffed at anyone who was freaking out about being super hungry on a low dose of reta. It sounded so counterintuitive, and now that I'm feeling it for myself, I'm like "oh, this DOES suck."
Yeah, it only feels counterintuitive until you’re the one actually dealing with it.

I don’t want to believe it’s not working, it just feels more like you’re in this transition phase where appetite control hasn’t really settled in yet, and I wouldn’t rush the dose.

Giving it at least another week, even two, helps your body settle a bit, when you do increase, it’s smoother and you’re less likely to get hit with side effects.
 
joseblo said:
I did a fast transition to Reta from Tirz over ~5 weeks (went from ~7.5mg/week T to ~6mg/week R). I did actually broke it up much like you did the first few shots, but then started separating out the doses to a full week to get the glucagon effect from dose peak.

The only thing I'd warn about is that it gave me the weirdest gastro sides even with LOTS of water/electo/fiber. Alternating golf balls and liquid, along with a complete stoppage for ~3 days which got me really worried and I took lots of laxatives. Gastroparesis will kill you. Then, everything normalized again except for the allodynia, eventually that went away at constant dose (I was on maintenance). Eventually, my aches and pains came back and I just switched back to Tirz+Survo like you were before. I guess I could use Maz instead with higher dose Tirz.

Best luck, but be careful of the gastro effects.
Thank you for this. I'll think on it. That's very close to my dosage-switch that I'm looking at (8 of tirz to whatever-works-reasonably-well of reta), so it's helpful to hear that experience. And I've never had a single digestive side effect from tirz, survo, or reta, but gastroparesis has always sounded VERY scary.
 
I am having the exact opposite situation - I have been a reta user and lost 70lbs and was thinking I'd try tirz our for maintenance because it's cheaper and I was hoping to tone down the weird skin shit and crap sleep - I've been pinning 5mg reta, I pinned 5mg tirz 2 days ago and I am ravenous. I'm thinking it doesn't matter which one your on, your first glp will just hit best.
 
ambot88 said:
I am having the exact opposite situation - I have been a reta user and lost 70lbs and was thinking I'd try tirz our for maintenance because it's cheaper and I was hoping to tone down the weird skin shit and crap sleep - I've been pinning 5mg reta, I pinned 5mg tirz 2 days ago and I am ravenous. I'm thinking it doesn't matter which one your on, your first glp will just hit best.

My current long term maintenance plan is favoring Tirz over Reta to drop the GCGR and give me and the system time to relax after cutting 80-90lb... luckily I still have time (40-50lb) to change my mind. 🤣

Cost is irrelevant to me, my cost difference is maybe a buck a month and I have a decade or more of either on hand.
 
ambot88 said:
I am having the exact opposite situation - I have been a reta user and lost 70lbs and was thinking I'd try tirz our for maintenance because it's cheaper and I was hoping to tone down the weird skin shit and crap sleep - I've been pinning 5mg reta, I pinned 5mg tirz 2 days ago and I am ravenous. I'm thinking it doesn't matter which one your on, your first glp will just hit best.
Another theory is that it's like when people switch anti-depressants. That the last one wasn't working the best for someone's current situation doesn't mean the next one will work better.

Reta has hit me differently at different times, as does tirz. Biologically, we are moving targets.
 
randompersonrandom said:
It was "Dr Trevor Bachmeyer" on Youtube, and I cannot emphasize enough that I would never listen to that dude yell into a microphone for even a quarter of a second. But somebody posted his video "Stop combining retatrutide with Tirzepatide" on a night when I was feeling tired and uncertain in general, and I read the transcript.
Dude's a fraud.

"Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020..."

Trevor Bachmeyer — Grokipedia

Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020, by the California Board of Chiropractic Exami

grokipedia.com

He reportedly likes to quote non-existent studies.
 
randompersonrandom said:
Yep--I was going to do that, and then the peptide bro quack doctor with a baseball hat and a beard got in my head about destroying my pancreas doing that. I thought "welp, if there's even a slight chance that he's right, why risk it? We'll just switch and titrate a little faster so the overlap isn't needed." That...may not be working.
Just hate watched that video you mentioned and stopped it as soon as he said Tirz is trash and he isn't selling us anything. Don't know how or why anyone watches this dude who got his education through AI like we all are lol
 
RetCurious said:
Dude's a fraud.

"Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020..."

Trevor Bachmeyer — Grokipedia

Trevor Bachmeyer (born circa 1973) is an American former licensed chiropractor (license number DC 29377) whose license was revoked effective July 8, 2020, by the California Board of Chiropractic Exami

grokipedia.com

He reportedly likes to quote non-existent studies.
I'm bookmarking this and putting it in every thread that mentions this goober 🤣
 
randompersonrandom said:
I've been on tirz since late June of '25, stacking a small dose of Survo against it since November or December with no intent to continue the survo in maintenance but wanting relief from fatigue. Lost almost all my excess weight and heading toward the end. Got ten years' worth of max dose tirz in my freezer, got mostly over my urge to hoard it because ok, that's enough to feel fairly un-anxious. Started slow-hoarding reta with no intention of actually using it for years, because I like meds that have been out in the general population for several years so we have real-world medium-term data, but figured there may come a time when I might want to switch in maintenance because people seem to love it so much. Got to three years worth, and said ok, hang on..it's fine that I don't want to be on it long term yet, but I should prolly try it for a few months and sacrifice a couple of vials to make sure it's even slightly ok for me, because won't I be disappointed someday if I decide to switch to it and find out it's terrible for me. Intend to titrate back down, switch back to tirz, and keep doing what I was doing when the two vials are up.

Last dose of tirz was 3/16. Started a 2.2 dose of reta. Got anxious, injected another 1.1, then another the next day, then another. Got ahold of myself, did 4.4 mg the following week, then 4.4 again. Didn't want to jump too high while I still had tirz overlap, or too fast because come on random, let's not screw around TOO much here.

Today's my shot day, and I could and maybe should do no more than 4.4 mg. If I do that this week and next week, then I'll probably be ok to titrate up after that. The trouble is, I'm a food monster over the last week. Sure, my period is coming and of course I'm hungrier, but Jesus, I'm ASHAMED of how much I ate yesterday. that feeling has been in my rear view mirror since last summer, so it's pretty scary to have that again.

I'm having no side-effects; I may as well be injecting straight bac for how the "feelz" are, which I know is such a common feeling with new reta users who have been on tirz. And I trust the source of my reta and it's well tested, I know it's not fake, this is just how it is at first for a lot of people and I'm one of them, ok. But I don't want to feel food obsessed. The three pounds the scale went up this week are almost certainly not fat, not with the amount of sugar and carbs I've been stuffing into my mouth and the upcoming period. It's water and ok. but it WILL be fat if I keep this up.

现在就断言“哦,瑞塔对我没用”,然后换回替扎尼定,停止囤瑞塔,还为时过早。我真的很想认真尝试一下。但我愿意听听大家的建议,下一步该怎么做:是继续服用4.4毫克,还是增加到5.5毫克或6.6毫克,或者尝试其他方法。我感觉自己好像看过无数次类似的经历,答案几乎总是“可能要到8毫克才会感觉到效果”,但我不想再经历几个月无法控制的状态,因为我已经非常习惯于掌控自己的情绪了。
我会继续服用替拉唑,然后逐渐以平衡体重的方式添加瑞达唑仑。每次减少1毫克替拉唑,同时增加1毫克瑞达唑仑。我每隔几天分别注射一次。我的理念是,身体需要时间来适应新的药物。
 
所以……我一直在犹豫要不要发这个帖子……

我现在服用的是4.5毫克的瑞他莫昔芬(Reta)、2.5毫克的替拉唑(Tirz)和1毫克的赛美莫昔芬(Sema)。四年前我开始服用奥沙利铂(Oz,即赛

美莫昔芬)。当时我的剂量已经达到2.4毫克(当时是最大剂量),直到后来加了替拉唑。赛美莫昔芬是唯一能帮我消除进食噪音的药物……没有之一。去年因为担心得了乳腺癌,做了手术,我停用了所有药物两个月……结果我饿得要命,体重反弹了7-8磅。这件事让我更加确信,我会一直服用这些药物,直到我再也停不下来为止。

当我重新开始服用GLP-1受体激动剂时……我一开始只服用瑞他莫昔芬,而且剂量很轻。但进食噪音仍然非常大。于是我开始加赛美莫昔芬。然后我发现我的手仍然很痛……但服用替拉唑的时候不会痛……所以我又加回了2.5毫克。现在一切都很好。

我也做 GHK-Cu/KPV 笔。
 
desinr-gal said:
我会继续服用替拉唑,然后逐渐以平衡体重的方式添加瑞达唑仑。每次减少1毫克替拉唑,同时增加1毫克瑞达唑仑。我每隔几天分别注射一次。我的理念是,身体需要时间来适应新的药物。
我就是这么从Reta切换到Tirz的,没有任何问题。只需要缓慢地、轻柔地切换即可。
 
tendency said:
我就是这么从Reta切换到Tirz的,没有任何问题。只需要缓慢地、轻柔地切换即可。
你知道吗,我想我应该摆脱这种胡思乱想,用这个方法完成剩下的“旅程”,然后再用这个方法返回。现在我打出“我让一个名声扫地的YouTube脊椎按摩师影响了我,让我接受了原本还算合理的计划,现在我的情况很糟糕”,我感觉自己真是太傻了。你和 @desinr-gal 说得对,这确实很蠢。
 
randompersonrandom said:
谢谢你的建议。我会考虑的。这跟我正在考虑的剂量调整(从8片Tirz换成效果还不错的Reta)非常接近,所以你的经验很有帮助。我服用Tirz、Survo和Reta从未出现过任何消化系统副作用,但胃轻瘫听起来一直很可怕。
Yeah, only time I've every had real gastro issues was the transition to reta.

I was really glad I was doing every 3 days rather than every day, since I was able to notice something was off before I kept increasing.
 
@randompersonrandom I have no advise on this subject as I've been Reta only for 3 months. My question, why the odd doses? 2.2, 4.4 and 6.6. Just curious.
 
BNLFL said:
@randompersonrandom I have no advise on this subject as I've been Reta only for 3 months. My question, why the odd doses? 2.2, 4.4 and 6.6. Just curious.
I never quit using the concentration I started with on compound, which is 22 mg/ml. That makes 10 units 2.2, 20 units 4.4, and so on up. I could adjust the concentration and the doses, but I never did get around to doing that; and the fact that I concentrate almost every glp1 the same and always have means I've never had to learn any new math for tirz and now reta. I'd have done it with survo too, but my starting and been-awhile dose for that were both so tiny.
 
woundcarping said:
Everyone has their own thoughts, here's my observations/experiences:

What was your Tirz dose?

I started Zep 12/12/25, I moved to compounded Tirz and was at 2.5mg 2x weekly until 1/10 when I moved to Reta. I took 7mg of Reta in total across 6 doses my first week. I've had 6 doses of Tirz since I started the bridge, totaling 14mg. I've had a total of 34 doses of Reta totaling 143mg. That averages 11.6mg/week with a chunk of that being getting my blood levels up using numerous small doses so I wouldn't overshoot and run into sides I had to wait out.

I moved to Reta for the GCGR signaling to boost BMR and presumptively spare lean mass better than Tirz.

GCGR signaling is dose dependent. Titrating Reta based on appetite/food noise is incorrect for reta, correct for Sema, Tirz, or Cagri. I titrated based on aversion to sides with the goal to get to or above 8mg/week levels for meaningful GCGR signaling.

I take Tirz PRN mainly to control food noise more so than hunger... my long term issue has been noise/brain side more than hunger/stomach side. I'll still take a bump if I expect the probability for trouble (like the 2.5mg dose in early March since I was traveling to either side of the country and back in 8 days).

Down 33lb since 1/10/25, 272lb to 239lb, practically all fat according to DEXA scans.

Had no meaningfully adverse sides.

Split dose, 2x weekly.

16mg/week with split dosing keeping my peaks only 15% higher than 12mg/once weekly (7mg 2x weekly has the same peaks).

RHR average hit a valley low of 58bpm on Tirz and is currently averaging 69-70bpm. This is inside my comfort level.

I don't expect 16mg to be magical over 12mg, but I do expect it to move my equilibrium point down ~10lb. That doesn't sound like much, but arguably that would be the hardest 10lb to lose. I chose to escalate my dose based on my sides and metrics including labs, fitness tracking, and sleep. I chose to do it now while I'm still resilient to the added stress vs later when systemic stress fatigue could be presenting.

Writing this post, I realized I failed to get labs on Lipase and Amylase to check my pancreas directly. My other labs suggest I'm doing fine, but gallstones/pancreatitis is my most likely hiccup. I'll get those labs drawn in the morning and report back if there's anything noteworthy.

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8mg/2x week is currently too much, I backed yesterday’s dose down to 7mg (14mg weekly).

Too much appetite suppression. More than transient lower gi symptoms, but manageable.

Down 4lb since that post from Monday, too much loss to sustain, but a one off isn’t a problem.

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i went from tirz 2.5mg EOD to reta 1mg every day. rebooted the feeling of being full after eating less but i'm always feeling hungry. starting to think i fell for the hype of reta when tirz was doing fine (though i did stall for 2 months and that's what got me to change). started losing weight again on reta so i'll stick it out for a bit. only been a few weeks. good luck to you
 
I am planning to do a little experimenting with reta myself. On 5mg Tirz for food noise at maintenance/lean bulk. The plan is to add a little reta (.5 to 1mg) when its time to do a mini cut. My hope is instead of cutting calories I can just turn things up a little bit and hopefully maintain more muscle during the cut.

Based on everything I've read from people using both, it really seems like Tirz is more of an appetite suppressor and reta is more of a metabolism booster. Both can have both effects (Triz definitely boosted my calorie burn) but better to have the best tool for each job.
 
Just cause new people might run into this thread years from now and be frustrated because they didn't get to see the resolution; I upped to 5.5 mg and added back in 3.3 mg of tirz, and I am now not struggling. I hit 130 yesterday (I'm 5'5"), which is a new low. I'm still aiming for 125, but I'm not trying particularly hard, just trying to mind calories and bicycling to the gym to swim most nights.
 
randompersonrandom said:
Just cause new people might run into this thread years from now and be frustrated because they didn't get to see the resolution; I upped to 5.5 mg and added back in 3.3 mg of tirz, and I am now not struggling. I hit 130 yesterday (I'm 5'5"), which is a new low. I'm still aiming for 125, but I'm not trying particularly hard, just trying to mind calories and bicycling to the gym to swim most nights.
And you've not had any annoying sides from the reta? I sadly had to stop at 2.5mg twice weekly, as even with the 8mg tirz I was still on didn't stop the hunger brought on by dropping the tirz from 11-12mg. Those 7 weeks I was on reta was all crappy sides like upped HR, bad sleep, hunger, lively gut (pepto almost every day) and sometimes I minor headache. Stopped the reta, and within 2 weeks all was well again. I'm at 139 (I'm 5'9") so although the weight is totally within a good range, the fact that I can grab fistfuls of fatty thigh to pin every day speaks to the need for pushing through my now 3 month stall. I wish reta had played nice with me, but I had to swipe left.
 
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