从蒂尔兹到雷塔的探测进展并不顺利。

[randompersonrandom]

我从2025年6月底开始服用Tirz，从11月或12月开始同时服用小剂量的Survo，我并不打算在维持治疗期间继续服用Survo，只是想缓解疲劳。我几乎减掉了所有多余的体重，疗程也接近尾声了。我的冰箱里囤了够用十年的最大剂量Tirz，我已经基本克服了囤药的冲动，因为好吧，这些药足以让我感觉不那么焦虑了。我开始慢慢囤积Reta，打算几年内都不用它，因为我喜欢那些已经上市好几年的药物，这样我们才能获得真实的中期疗效数据。但我琢磨着，也许将来某个时候我会想在维持治疗期间换用Reta，因为很多人似乎都很喜欢它。用了三年的量，我想，好吧，等等……我知道我现在还不想长期服用，但我应该先试用几个月，牺牲几瓶药，确保它对我来说哪怕只有一点点效果，因为如果我决定换用它，结果发现它对我的副作用很大，我会很失望的。我打算逐渐减少剂量，换回替拉唑，等这两瓶药用完后，再继续之前的用药方案。

最后一次注射替拉唑是3月16日。开始注射2.2毫克的瑞达。有点焦虑，又注射了1.1毫克，第二天又注射了一次，然后又注射了一次。我控制住了自己，接下来一周注射了4.4毫克，然后又是4.4毫克。我不想在替拉唑的药效还没完全消退的时候剂量增加太多，也不想增加得太快，毕竟随机性太强了，我们可不能在这里胡乱尝试。

今天是我注射的日子，我最多只能注射4.4毫克，也许应该也只能做到这样。如果我这周和下周都保持这个剂量，之后应该就可以逐渐增加剂量了。问题是，过去一周我简直成了个吃货。当然，我的月经快来了，我肯定会更饿，但是天哪，我昨天吃得那么多，真是羞愧难当。这种感觉从去年夏天就一直困扰着我，所以再次经历这种感觉真的挺可怕的。

我没有任何副作用；就感觉而言，我感觉就像是直接注射了复方制剂一样，我知道这对于之前用过替诺福韦的新用户来说很常见。而且我相信我的替诺福韦来源，它经过了充分的测试，我知道它不是假货，很多人一开始都会这样，我也是其中之一，好吧。但我不想再这样对食物上瘾了。这周体重增加的三磅几乎肯定不是脂肪，考虑到我最近摄入的糖和碳水化合物，再加上即将到来的生理期，这肯定不是脂肪。这主要是水分，没关系。但如果我继续这样下去，肯定会变成脂肪。

现在就断言“哦，瑞塔对我没用”，然后换回替扎尼定，停止囤瑞塔，还为时过早。我真的很想认真尝试一下。但我愿意听听大家的建议，下一步该怎么做：是继续服用4.4毫克，还是增加到5.5毫克或6.6毫克，或者尝试其他方法。我感觉自己好像看过无数次类似的经历，答案几乎总是“可能要到8毫克才会感觉到效果”，但我不想再经历几个月无法控制的状态，因为我已经非常习惯于掌控自己的情绪了。

 

[Abrakebabra]

如果你只是因为害怕错过什么才换用瑞达（Reta），那我个人建议你还是继续用替尔兹（Tirz），因为它看起来效果不错，也能满足你的需求。你换药还有其他原因吗？比如想要从胰高血糖素方面获得什么效果？我建议你不要再增加瑞达的剂量了，因为一旦副作用出现，可能会非常严重。

 

[Beardboost]

你的身体需要适应Reta，它不像Triz那样能强烈抑制食欲，起效也更慢。你需要制定一个适合自己的饮食计划，每天喝3-4升水。因为Reta没有立竿见影的效果就第二天再注射是疯狂的，罗马也不是一天建成的。

 

[Calm Logic]

Of course, some people do both tirz and reta, especially when switching over. I am still tirz-based (most of the time) but stack for the shits and the giggles.

From what I have seen/read, the number one mistake when switching over to reta is to stop tirz completely or switch over too fast (with not enough weeks of overlap).

But stopping tirz completely before starting reta does seem safer on paper (with no studies on stacking). And there is still tirz in one's system for a few weeks.

 

[randompersonrandom]

If you have only switched to Reta because of FOMO then personally I'd just stick with Tirz as that seemed to be working and doing what you needed it to. Do you have any other reason for switching? Wanting anything from the Glucagon part etc? I wouldn't go ramping up the Reta anymore as if/when the side effects do come, they are likely to hit you hard.

Well, if it genuinely does work fine and maybe even better when I get to the right dose, then I'll keep what I've got and still buy a kit here and there to store. I worry that grey will go away or become MUCH less easy to come by in the coming years. If it never works for me and tirz is genuinely just better after a reasonable dose on reta, then I'll certainly quit buying a kit here and there because that one's a no for me. It's always been my intention to switch back to tirz for the time being when the experiment is over even if it works well for me.

 

[randompersonrandom]

Your body needs to adjust to Reta, its not a huge appetite suppression compared to Triz, it takes longer, you need to dial in a planned diet that suits you, 3-4L of water per day, Injecting the next day because you don't have instant effects is crazy, Rome was not built in a day

I never expected instant effects, I just got to second-guessing myself on such a low dose when I wasn't starting from nothing (since the tirz/survo or ghetto-reta had been at a moderate dose for quite awhile).

I HAVE a planned diet that suits me, and has for quite some time. Now, all of a sudden, my low-carb high-protein water-heavy diet is...not enough, I want all of the food in a brutal way.

 

[randompersonrandom]

Of course, some people do both tirz and reta, especially when switching over. I am still tirz-based (most of the time) but stack for the shits and the giggles.

From what I have seen/read, the number one mistake when switching over to reta is to stop tirz completely or switch over too fast (with not enough weeks of overlap).

Yep--I was going to do that, and then the peptide bro quack doctor with a baseball hat and a beard got in my head about destroying my pancreas doing that. I thought "welp, if there's even a slight chance that he's right, why risk it? We'll just switch and titrate a little faster so the overlap isn't needed." That...may not be working.

 

[Mara_aa]

I've been on tirz since late June of '25, stacking a small dose of Survo against it since November or December with no intent to continue the survo in maintenance but wanting relief from fatigue. Lost almost all my excess weight and heading toward the end. Got ten years' worth of max dose tirz in my freezer, got mostly over my urge to hoard it because ok, that's enough to feel fairly un-anxious. Started slow-hoarding reta with no intention of actually using it for years, because I like meds that have been out in the general population for several years so we have real-world medium-term data, but figured there may come a time when I might want to switch in maintenance because people seem to love it so much. Got to three years worth, and said ok, hang on..it's fine that I don't want to be on it long term yet, but I should prolly try it for a few months and sacrifice a couple of vials to make sure it's even slightly ok for me, because won't I be disappointed someday if I decide to switch to it and find out it's terrible for me. Intend to titrate back down, switch back to tirz, and keep doing what I was doing when the two vials are up.

Last dose of tirz was 3/16. Started a 2.2 dose of reta. Got anxious, injected another 1.1, then another the next day, then another. Got ahold of myself, did 4.4 mg the following week, then 4.4 again. Didn't want to jump too high while I still had tirz overlap, or too fast because come on random, let's not screw around TOO much here.

Today's my shot day, and I could and maybe should do no more than 4.4 mg. If I do that this week and next week, then I'll probably be ok to titrate up after that. The trouble is, I'm a food monster over the last week. Sure, my period is coming and of course I'm hungrier, but Jesus, I'm ASHAMED of how much I ate yesterday. that feeling has been in my rear view mirror since last summer, so it's pretty scary to have that again.

I'm having no side-effects; I may as well be injecting straight bac for how the "feelz" are, which I know is such a common feeling with new reta users who have been on tirz. And I trust the source of my reta and it's well tested, I know it's not fake, this is just how it is at first for a lot of people and I'm one of them, ok. But I don't want to feel food obsessed. The three pounds the scale went up this week are almost certainly not fat, not with the amount of sugar and carbs I've been stuffing into my mouth and the upcoming period. It's water and ok. but it WILL be fat if I keep this up.

It's too soon to declare "oh, reta is no good for me," switch back to tirz, and stop stocking reta. I really want to give this a fair shot. But I'm open to suggestions on what to do next; stay at 4.4, go up to 5.5 or 6.6, or do something else. I feel like I've read this exact same experience dozens of times and the answer is almost always "you may not feel anything til you get to 8 mg" but I don't want to be hanging out out of control for months more when I'm super used to HAVING that control.

One thing I’d consider, right now you’re not just “testing reta,” you’re also feeling the absence of tirz at the same time. That overlap makes it hard to tell what’s actually happening.

If it were me, I’d focus less on chasing the “right” reta dose this early and more on getting through a clean transition phase first.

Because otherwise it’s easy to blame reta for something that might just be the gap left by tirz,especially with a pre-period week in the mix.

For me, low doses of Reta just make me super hungry. Hopefully it’s only at the beginning.

 

[randompersonrandom]

One thing I’d consider, right now you’re not just “testing reta,” you’re also feeling the absence of tirz at the same time. That overlap makes it hard to tell what’s actually happening.

If it were me, I’d focus less on chasing the “right” reta dose this early and more on getting through a clean transition phase first.

Because otherwise it’s easy to blame reta for something that might just be the gap left by tirz,especially with a pre-period week in the mix.

For me, low doses of Reta just make me super hungry. Hopefully it’s only at the beginning.

I keep looking at that--if my last dose of 8.8 was 3-16, and I was at steady state, then the amount still in me today should be 0.66 mg. That's close enough to "gone" that I feel like it's safe at this point to say "ok, this is how I feel on this dose of reta."

I'm really glad I never scoffed at anyone who was freaking out about being super hungry on a low dose of reta. It sounded so counterintuitive, and now that I'm feeling it for myself, I'm like "oh, this DOES suck."

 

[Calm Logic]

I'm really glad I never scoffed at anyone who was freaking out about being super hungry on a low dose of reta. It sounded so counterintuitive, and now that I'm feeling it for myself, I'm like "oh, this DOES suck."

This is why more vendors need to sell lira. Very few do, though it is available as a generic pen from India. The short half-life makes it easier to give yourself a GLP boost without worrying (as much) about going to the hospital later.

 

[Zydeceltico]

Well, if it genuinely does work fine and maybe even better when I get to the right dose, then I'll keep what I've got and still buy a kit here and there to store. I worry that grey will go away or become MUCH less easy to come by in the coming years........

You could just alter your mindset a little and realize that even if the grey goes away, the masses desire for reta won't and capitalism will never die AND those once-in-awhile purchases of a reta kit here and there that you will never use will then probably skyrocket in resale value.



That way you don't have to completely give up the ever-entertaining hoarding hobby.

Just sayin....... lol

 

[DragonOfTheSea]

Yep--I was going to do that, and then the peptide bro quack doctor with a baseball hat and a beard got in my head about destroying my pancreas doing that.

Did bro hat doc cite anything regarding this pancreas destroying regiment? Anyone else got anything on this because that’s news to me.

 

[woundcarping]

It's too soon to declare "oh, reta is no good for me," switch back to tirz, and stop stocking reta. I really want to give this a fair shot. But I'm open to suggestions on what to do next; stay at 4.4, go up to 5.5 or 6.6, or do something else. I feel like I've read this exact same experience dozens of times and the answer is almost always "you may not feel anything til you get to 8 mg" but I don't want to be hanging out out of control for months more when I'm super used to HAVING that control.

Everyone has their own thoughts, here's my observations/experiences:

What was your Tirz dose?

I started Zep 12/12/25, I moved to compounded Tirz and was at 2.5mg 2x weekly until 1/10 when I moved to Reta. I took 7mg of Reta in total across 6 doses my first week. I've had 6 doses of Tirz since I started the bridge, totaling 14mg. I've had a total of 34 doses of Reta totaling 143mg. That averages 11.6mg/week with a chunk of that being getting my blood levels up using numerous small doses so I wouldn't overshoot and run into sides I had to wait out.

I moved to Reta for the GCGR signaling to boost BMR and presumptively spare lean mass better than Tirz.

GCGR signaling is dose dependent. Titrating Reta based on appetite/food noise is incorrect for reta, correct for Sema, Tirz, or Cagri. I titrated based on aversion to sides with the goal to get to or above 8mg/week levels for meaningful GCGR signaling.

I take Tirz PRN mainly to control food noise more so than hunger... my long term issue has been noise/brain side more than hunger/stomach side. I'll still take a bump if I expect the probability for trouble (like the 2.5mg dose in early March since I was traveling to either side of the country and back in 8 days).

Down 33lb since 1/10/25, 272lb to 239lb, practically all fat according to DEXA scans.

Had no meaningfully adverse sides.

Split dose, 2x weekly.

16mg/week with split dosing keeping my peaks only 15% higher than 12mg/once weekly (7mg 2x weekly has the same peaks).

RHR average hit a valley low of 58bpm on Tirz and is currently averaging 69-70bpm. This is inside my comfort level.

I don't expect 16mg to be magical over 12mg, but I do expect it to move my equilibrium point down ~10lb. That doesn't sound like much, but arguably that would be the hardest 10lb to lose. I chose to escalate my dose based on my sides and metrics including labs, fitness tracking, and sleep. I chose to do it now while I'm still resilient to the added stress vs later when systemic stress fatigue could be presenting.

Writing this post, I realized I failed to get labs on Lipase and Amylase to check my pancreas directly. My other labs suggest I'm doing fine, but gallstones/pancreatitis is my most likely hiccup. I'll get those labs drawn in the morning and report back if there's anything noteworthy.

 

[randompersonrandom]

This is why more vendors need to sell lira. Very few do, though it is available as a generic pen from India. The short half-life makes it easier to give yourself a GLP boost without worrying (as much) about going to the hospital later.

God damnit @Calm Logic , the goal here was to make sure I wasn't buying peps that I don't need, not buy MORE peps that I don't need to make the peps I may not need more needable!

BRB, ordering more Survo cause what if I run out

 

[Calm Logic]

Did bro hat doc cite anything regarding this pancreas destroying regiment? Anyone else got anything on this because that’s news to me.

It's more the absence of studies. There are zero studies on stacking any GLPs.

So my board-certified internist assumes that stacking Rx sema with Rx tirz is insane.

 

[randompersonrandom]

You could just alter your mindset a little and realize that even if the grey goes away, the masses desire for reta won't and capitalism will never die AND those once-in-awhile purchases of a reta kit here and there that you will never use will then probably skyrocket in resale value.



That way you don't have to completely give up the ever-entertaining hoarding hobby.

Just sayin....... lol

You know, this is Probably The Way.

 

[Zydeceltico]

You know, this is Probably The Way.

I do.

 

[randompersonrandom]

It's more the absence of studies. There are zero studies on stacking any GLPs.

So my board-certified internist assumes that stacking Rx sema with Rx tirz is insane.

It was "Dr Trevor Bachmeyer" on Youtube, and I cannot emphasize enough that I would never listen to that dude yell into a microphone for even a quarter of a second. But somebody posted his video "Stop combining retatrutide with Tirzepatide" on a night when I was feeling tired and uncertain in general, and I read the transcript.

 

[joseblo]

I've been on tirz since late June of '25, stacking a small dose of Survo against it since November or December with no intent to continue the survo in maintenance but wanting relief from fatigue. Lost almost all my excess weight and heading toward the end. Got ten years' worth of max dose tirz in my freezer, got mostly over my urge to hoard it because ok, that's enough to feel fairly un-anxious. Started slow-hoarding reta with no intention of actually using it for years, because I like meds that have been out in the general population for several years so we have real-world medium-term data, but figured there may come a time when I might want to switch in maintenance because people seem to love it so much. Got to three years worth, and said ok, hang on..it's fine that I don't want to be on it long term yet, but I should prolly try it for a few months and sacrifice a couple of vials to make sure it's even slightly ok for me, because won't I be disappointed someday if I decide to switch to it and find out it's terrible for me. Intend to titrate back down, switch back to tirz, and keep doing what I was doing when the two vials are up.

Last dose of tirz was 3/16. Started a 2.2 dose of reta. Got anxious, injected another 1.1, then another the next day, then another. Got ahold of myself, did 4.4 mg the following week, then 4.4 again. Didn't want to jump too high while I still had tirz overlap, or too fast because come on random, let's not screw around TOO much here.

Today's my shot day, and I could and maybe should do no more than 4.4 mg. If I do that this week and next week, then I'll probably be ok to titrate up after that. The trouble is, I'm a food monster over the last week. Sure, my period is coming and of course I'm hungrier, but Jesus, I'm ASHAMED of how much I ate yesterday. that feeling has been in my rear view mirror since last summer, so it's pretty scary to have that again.

I'm having no side-effects; I may as well be injecting straight bac for how the "feelz" are, which I know is such a common feeling with new reta users who have been on tirz. And I trust the source of my reta and it's well tested, I know it's not fake, this is just how it is at first for a lot of people and I'm one of them, ok. But I don't want to feel food obsessed. The three pounds the scale went up this week are almost certainly not fat, not with the amount of sugar and carbs I've been stuffing into my mouth and the upcoming period. It's water and ok. but it WILL be fat if I keep this up.

It's too soon to declare "oh, reta is no good for me," switch back to tirz, and stop stocking reta. I really want to give this a fair shot. But I'm open to suggestions on what to do next; stay at 4.4, go up to 5.5 or 6.6, or do something else. I feel like I've read this exact same experience dozens of times and the answer is almost always "you may not feel anything til you get to 8 mg" but I don't want to be hanging out out of control for months more when I'm super used to HAVING that control.

I did a fast transition to Reta from Tirz over ~5 weeks (went from ~7.5mg/week T to ~6mg/week R). I did actually broke it up much like you did the first few shots, but then started separating out the doses to a full week to get the glucagon effect from dose peak.

The only thing I'd warn about is that it gave me the weirdest gastro sides even with LOTS of water/electo/fiber. Alternating golf balls and liquid, along with a complete stoppage for ~3 days which got me really worried and I took lots of laxatives. Gastroparesis will kill you. Then, everything normalized again except for the allodynia, eventually that went away at constant dose (I was on maintenance). Eventually, my aches and pains came back and I just switched back to Tirz+Survo like you were before. I guess I could use Maz instead with higher dose Tirz.

Best luck, but be careful of the gastro effects.

 

[DragonOfTheSea]

It was "Dr Trevor Bachmeyer" on Youtube, and I cannot emphasize enough that I would never listen to that dude yell into a microphone for even a quarter of a second. But somebody posted his video "Stop combining retatrutide with Tirzepatide" on a night when I was feeling tired and uncertain in general, and I read the transcript.

I had to look it through out of curiosity…

His entire foundation of his argument is that stacking Tirz and Reta creates receptor overstimulation, cause receptor retreat. He also states over and over that the glucagon signalling is in opposition to GLP/gip signalling Except that Reta fundamentally activates all three receptors… why isn’t Reta a self contradicting drug, then? Oh because he says that stacking overstimulates the GLP/gip receptors, right ok.. but what if you aren’t max dosing both? Or either?

I feel his argument is based around dumping max dosages of both.. and if you’re doing that, well then I can see validity for his argument, but a low or moderate stack of both, say both at 50% or lower of current trial “max” dosages, could not possibly be flood-overstimulating the receptors any more than max dosage of either one.