Body stopped responding
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Calm Logic
GLP-1 Specialist
IndiaMart.com is the Indian version of Made-In-China.com.
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For anything about India, I read and cherish every post by @AndyPanda
tncc_rn
GLP-1 Enthusiast
survo + tirz is my current stack. I was doing Triz+Cargi and Reta+Cargi 4/days later as suggested by another board member. But I found its easier to do Triz and Survo on a more regular basis.Calm Logic said:
Nmcoyote1
GLP-1 Apprentice
I just had a doctor suggest stacking it with Sema to get the last 30 pounds off. So I did a search for any mentions of Qsymia. I was also considering TesifensineCalm Logic said:
Voidnoodle said:
From the research I’ve read and anecdotal accounts online, it would seem that prior use of a glp-1 appears to require higher levels of the new glp-1 to achieve results when some time has spent off the first medication. Since you had success on Wegovy, I personally would keep titrating up on the tirzepatide. You’ve only been on tirzepatide for 3 weeks…And only recently taken 10mg. You have a lot of room to increase your dosing.
lessthanhalf
GLP-1 Specialist
I do not know if the original poster is still around or has sorted this problem out or not, but anyway.Voidnoodle said:
Restarting or changing GLP medications once you have already lost 100 pounds, is a totally different physiological state to starting them before losing weight. I think it is important to understand this issue otherwise the effects over time do not seem to make sense and it seems like they stop working, or you develop tolerance, which is not what is happening. And I see people getting stuck in this logic trap all the time on this forum.
When you start to lose weight your body is used to a high caloric intake, and has a much higher than normal metabolic rate due to increased weight and increased wastage of excess calories as heat. So that at the start weight loss is rapid, especially if you are severely overweight.
After losing that much weight , your body reacts by conserving energy, dropping resting metabolic rate. Calories consumed by your body per day goes down quite a lot just from losing the weight, but then on top of that you get metabolic adaptation to chronic starvation reducing calories consumed per day by quite a lot more.
When I was losing weight I ate the same number of calories per day at the start and at the end, about 1600 to 1800 kcal/day. At the start I lost exactly 6 kilograms per month from 145 kg to about 90kg , then with no change in diet weight loss gradually slowed down and finally stopped at about 75kg.
Unfortunately that is not the only problem. As you lose weight hunger increases as well . It is this combination of lowered metabolic requirements , so that you have to eat a fair bit less than normal to maintain the lower weight , plus more hunger than normal that makes keeping weight off long term really hard.
So whether you were taking GLP medications to lose the weight or not, you are still in this state after losing weight.
If you stay on the medication or change it to another it will seem like it is not working , as you are no longer losing weight and you are more hungry, but if you are not putting weight back on then it is actually working perfectly . At best Tirzepatide can cause about 25% weight loss on average, so if that 100 pounds was 25% of your start weight then it has worked as well as the average, and 50% of people taking it will lose less than 25%, and 50 % will lose more.
If you are on maximum dose of 15mg a week and gaining weight then there are no good easy answers, other than experimenting with higher doses or combining GLP medications like adding cagrilintide. Or some of the other suggestions in this thread.
I only started GLP medications a year after losing most of my excess weight so I have personal experience of this state, and they help a lot to keep hunger under control and reduce or prevent weight regain better than anything else ever has before. But they are not perfect and for people with more severe obesity they do not entirely solve the problem , but they do help, and 25% less overweight is a lot better than 0% less overweight.
nonyabizznez said:
I have to admit that I’ve spent too much time on Reddit in the compound tirzepatide subreddit and these types of posts would drive me crazy and part the reason I no longer frequent that sub. OP basically on tirzepatide 3 weeks and not at highest dose and no results…. At least OP is on 10mg. The ones that truly drive me bananas is the microdose folks that complain about no results
….Kalliste73
GLP-1 Novice 🚫No Source Discussion🚫
I had the same experience with Reta.Voidnoodle said:
I used it for about a year, starting with 1mg a week.
I reached my "sweat spot" of 5mg a week, where I lost about 22kg in total over this period of time.
But the greatest thing was the body recomposition (training with weights almost every day and trying to eat as well as possible).
I returned to the athlete's physique I had about 7-8 years ago before I got chronically ill and gained weight due to all that this brought to me and my life.
After about a year on Reta from 1 to 5mg a week, I started to "stall" and increased the doses to 7.5mg a week until reaching 10mg a week, but I no longer saw any benefits, only problems related to my delicate physical condition, and I had to stop it.
so I switched to tirze, up to 5mg a week here too for another 6 months or so without any benefit or results, on the contrary, I lost lean mass and put on water/fat.
so I also stopped with the tirze, I started the mazdutide, I have been increasing the dose for about 2 months, week after week starting from 0.25mg to get to 5mg a week and then continue with this dose and see if there will be results.
I'm currently at 3mg and up and haven't seen any drop in body fat, just some mental benefits, it keeps me from overeating or having cravings of any kind, plus it's gotten rid of some addictions (good!)
I'm aware that I'll see a drop in body fat (hopefully) when I stabilize the dose, not right now, so we'll see later if I get the desired results (also because in the meantime I've gone back to the weight I was about 2 years ago - a lot of wasted work and time and money, basically).
oh, just for completeness, before starting the reta, more or less 2.5 years ago, I tried sema but I was inexperienced and I increased the dose too quickly (at the time I was totally virgin from glp-1s) and the sides suffocated me, so even though I had good weight loss results, I also had to stop the sema because the sides were too heavy to manage.
randompersonrandom
GLP-1 Specialist
Grogu said:
If we find out that it's not a physiological thing, I'll bet we're going to find out that "it's less effective the second time you go on it" has to do with "the first time you go on it, you figure it's magic because of all the hype, and as soon as you go on it, you get hit with placebo magic long before you're even at an effective dose, which carries you all the way into where the effective dose happens."
I'm super susceptible to placebo effect, something I do absolutely NOTHING to combat, because bring it on. My very first shot of 2.2 tirz, within three hours I felt very different, and I lost a large amount of my weight before I even hit 5 mg. I'm on 8 mg now, and if I discontinued for months and then came back to 2.2, I wouldn't feel like that was much or likely to be effective because I think of effective as my current dose, 8, so I'm sure it WOULDN'T be the same (for me) the second time.
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