Black Seed supplement

[CheesyPotato]

Wondering if anyone has experience with the Black seed cumin oil supplement? It's been noted as having potent anti-inflammatory and immune modulating properties. I've been on a quest to find something to control pain/chronic inflammation(not prednisone, was on it way too long) better. Current research is TA-1, ARA, KPV, TB but the effects are slight unfortunately.

 

[Chili777]

I have not tried this, personally, but I know a few researchers who swear by it. They initially purchased it as a supplement for gastro support after starting a GLP because it helps digestion during the early "shutdown" phase, when digestion is slowed and BMs are fewer and far between. They had severe constipation and used Black Cumin as relief and reported good results.The additional antiinflammatory benefits make it even better.

I've found KPV and TA-1 to be beneficial for me, but they take time to work. I cycled TA-1 for 60 days and I'm ending a 90-day cycle of KPV shortly. It has reduced my atopic dermatitis, to the point where I've been able to stretch my biologic dose to every month, instead of every two weeks, and my use of topical preparations to rarely now, but everyone one is different.

 

[Calm Logic]

I used to be curious about black seed oil, but I never tried it. As an anti-inflammatory, it seems better for metabolism than healing, like for lowering LDL.

I am seeing PE 22-88 more often now. It is supposed to boost cognition/mood as well as help with chronic pain. If you know who Turtle Express is on TG, their website (different name) sells the vials individually as well.

Hell, maybe even try PT-141 if you haven't already. I'm not joking, and it can help mood in general. Even in ancient Greek psychology, there is "the therapy of desire" (desire in general, i.e. neurosignaling in the engagement circuits) for dealing with the pains of life (physical and emotional).

As you may know, some people say they got more anti-inflammatory feelz (less pain) on tirz than reta (with reta better on paper for weight loss, lowering LDL, and liver enzymes). So some people will take both or maybe ghetto reta to get some of the best of both worlds. I know you are not on reta yet.

 

[Calm Logic]

I've found KPV and TA-1 to be beneficial for me, but they take time to work. I cycled TA-1 for 60 days and I'm ending a 90-day cycle of KPV shortly. It has reduced my atopic dermatitis, to the point where I've been able to stretch my biologic dose to every month, instead of every two weeks, and my use of topical preparations to rarely now, but everyone one is different.

Care to share you dosing for TA-1 and KPV?

Similar thread on Reddit (I know, I know), with dosing on the low end, and frequency only once a day for the KPV:

Feels like everyone is focused on the usual peptides, but Thymosin Alpha 1 + KPV might be one of the most logical stacks out there.

You’ve got TA1, which is actually used clinically in a lot of countries for immune modulation… and then KPV which seems to target inflammation (especially gut-related).

So instead of just “stimulating” anything, it feels more like: regulate the immune system + reduce unnecessary inflammation.

I’ve been taking them together and the biggest thing I’ve noticed is just feeling more resilient overall — like my body handles stress/sickness better.

Not saying it’s magic, but it’s definitely one of the more “functional” stacks I’ve tried.

I have what my doctor hinted at as fibromyalgia. I also have other autoimmune issues with thyroid disease. I have chronic tightness, muscle knots and pain in my neck, shoulders, and upper back. PT, chiropractic, home exercises and stretching, and massage keeps it from full-blown flare-ups usually, but adding KPV has calmed down the pain and tightness and haven't needed ibuprofen since I started it.

TA1 3 x per week, 1mg per dose

KPV 5 x per week, 0.5mg per dose

I like to take post dinner, but not sure timing is as important as with other compounds.

View: https://www.reddit.com/r/PeptidePathways/comments/1rzzi25/ta1_kpv_might_be_one_of_the_most_underrated_stacks/

 

[Neurogroot]

Wondering if anyone has experience with the Black seed cumin oil supplement? It's been noted as having potent anti-inflammatory and immune modulating properties. I've been on a quest to find something to control pain/chronic inflammation(not prednisone, was on it way too long) better. Current research is TA-1, ARA, KPV, TB but the effects are slight unfortunately.

Black seed oil… is this the same thing as “Bioperine”, added to supplements to increase absorption for medications, or is this something entirely different?

 

[Chili777]

Care to share you dosing for TA-1 and KPV?

Similar thread on Reddit (I know, I know), with dosing frequency only once a day for the KPV:

TA1 + KPV might be one of the most underrated stacks
by
u/Sea-Performer-71 in
PeptidePathways

View: https://www.reddit.com/r/PeptidePathways/comments/1rzzi25/ta1_kpv_might_be_one_of_the_most_underrated_stacks/

Click to expand...

I ran KPV at 500 mcg daily for 3 months and TA-1 at 1.6 mg daily for 60 days. KPV is pretty forgiving with no detectable side effects, and I know of people that have run 2 mg+ daily, but I noticed skin improvements at 500 mcg. With TA-1, the protocols specify 1.6 mg consistently, but what changes is the frequency. 2x daily for acute conditions, 1x daily for immune support and 3x a week for general wellness. I dosed right before bed and that worked for me. There is no action from either that should impact sleep, so timing shouldn't matter, just consistency. The protocols I saw say TA-1 should be taken at the same time every day.

 

[lessthanhalf]

Have not read the research on black seed oil, but I will mention that it is exactly the type of supplement that has a very high chance of being dodgy if bought on amazon, newish fashionable or expensive.

The one compound that is reasonably available with really very good evidence, by any standard and amazing for a supplement where the research is usually very thin to put it nicely, is PEA or palmitoylethanolamine, with a few hundred studies showing it reduces chronic pain and unusually works slowly and increases in effect over 4 to 8 weeks. Not super cheap and I think 90% of the ones on Amazon US are dodgy, one had pills that weighed 300mg despite advertising 1450mg per capsule. Maybe iherb, micronised is preferable. Liposomal would be good but as far as I can tell every single brand advertising this is dodgy. Plain PEA needs 2-4 times the dose of 600mg x 2 micronised version. It did not fix my chronic gut pain from ulcerative colitis/ IBS-d as much as I hoped but helped with chronic pain from a sensory peripheral neuropathy.

The level of scientific evidence supporting its use for chronic pain is in a different league to any of the peptides, and oddly it has no known side effects.

 

[DunningKruger]

Wondering if anyone has experience with the Black seed cumin oil supplement? It's been noted as having potent anti-inflammatory and immune modulating properties. I've been on a quest to find something to control pain/chronic inflammation(not prednisone, was on it way too long) better. Current research is TA-1, ARA, KPV, TB but the effects are slight unfortunately.

I also haven't read much research on black seed oil aside from the antimicrobial uses. So, I can't help you there.

Are you using ARA and KPV locally? I suffer from neuropathic pain and find that KPV injected locally can vastly reduce pain signalling for approximately 7-8 hours.

 

[CheesyPotato]

Black seed oil… is this the same thing as “Bioperine”, added to supplements to increase absorption for medications, or is this something entirely different?

Not the same, Bioperine is an extract of piperine from black pepper. Black seed oil is from the Nigella seed plant. From everything I've read, it may help with inflammation and wound healing. It contains contains thymoquinone, which is an antioxidant and has anti-inflammatory properties. A few on another forum had suggested trying it because it's helped their inflammation.

 

[CheesyPotato]

I also haven't read much research on black seed oil aside from the antimicrobial uses. So, I can't help you there.

Are you using ARA and KPV locally? I suffer from neuropathic pain and find that KPV injected locally can vastly reduce pain signalling for approximately 7-8 hours.

I was using it systemically, I did finally get some relief, very noticeable when I cycled off, especially in hands and feet. I'm looking forward to going back on. Ran the cycle for 3 months.

 

[CheesyPotato]

Have not read the research on black seed oil, but I will mention that it is exactly the type of supplement that has a very high chance of being dodgy if bought on amazon, newish fashionable or expensive.

The one compound that is reasonably available with really very good evidence, by any standard and amazing for a supplement where the research is usually very thin to put it nicely, is PEA or palmitoylethanolamine, with a few hundred studies showing it reduces chronic pain and unusually works slowly and increases in effect over 4 to 8 weeks. Not super cheap and I think 90% of the ones on Amazon US are dodgy, one had pills that weighed 300mg despite advertising 1450mg per capsule. Maybe iherb, micronised is preferable. Liposomal would be good but as far as I can tell every single brand advertising this is dodgy. Plain PEA needs 2-4 times the dose of 600mg x 2 micronised version. It did not fix my chronic gut pain from ulcerative colitis/ IBS-d as much as I hoped but helped with chronic pain from a sensory peripheral neuropathy.

The level of scientific evidence supporting its use for chronic pain is in a different league to any of the peptides, and oddly it has no known side effects.

Thanks for this information. I've been seeing PEA popping up on supplement sites, and wondered about it, but haven't dug into it. Boswellia Serrata and Astaxthin are a couple of others, bought a bottle of each after a lot of searching trying to find a reputable source that has true lab testing, less to no fillers etc what a chore that was. I sound pretty desperate, actually I am somewhat lol The traditional meds aren't helping, actually made condition worse which is why I'm in this mess. Trying to straighten out an immune system that was suppressed for 10 years isn't going to be an easy task if it's even possible but God willing I'll get there

Ok, my whining session is over lol

Happy Friday y'all!

 

[UpDownLeftRightAS*]

Reminds me of Shilajit. The only way I can take it is via pill, not the spoon/ bottle version....and even then, the flavor kills me (Shilajit & Black Seed). It's supposed to be an amazing component to raising Testosterone levels though....(as I've heard though conjecture). Quality variability is the biggest risk/ concern for Black Seed....cant go cheap.

 

[RubbaDubba1]

Thanks for this information. I've been seeing PEA popping up on supplement sites, and wondered about it, but haven't dug into it. Boswellia Serrata and Astaxthin are a couple of others, bought a bottle of each after a lot of searching trying to find a reputable source that has true lab testing, less to no fillers etc what a chore that was. I sound pretty desperate, actually I am somewhat lol The traditional meds aren't helping, actually made condition worse which is why I'm in this mess. Trying to straighten out an immune system that was suppressed for 10 years isn't going to be an easy task if it's even possible but God willing I'll get there

Ok, my whining session is over lol

Happy Friday y'all!

Love me some https://nootropicsdepot.com/ more specialty and or if I figure it's gonna work it will be from these guys. I'll step down to Sports Research, after researching (haha) for my 2nd choice and get at Costco on sale is pretty good. I'll get a couple more common things from Nutricost.

 

[CheesyPotato]

Love me some https://nootropicsdepot.com/ more specialty and or if I figure it's gonna work it will be from these guys. I'll step down to Sports Research, after researching (haha) for my 2nd choice and get at Costco on sale is pretty good. I'll get a couple more common things from Nutricost.

Thanks I'll give nootropicsdepot a lookover. I've been ordering from Thorne and LifeExtension, once in awhile Bronson labs.

 

[Calm Logic]

Regarding TA1+KPV, per Gemini:

 

[aepower2016]

I used black seed oil about 3-4 years ago. I had diluted version to take "shots" of it when I had a cold. It tasted horribly sort of like gasoline but it did shorten the lifespan of the virus. 2nd go around was to help reverse balding. It seemed like it was working however I couldn't bare the smell and sticky residue it would leave on my hair. Certainly felt like getting legit black seed oil could have many potential benefits!