Anyone else a slow burn with reta?

[meeklady]

Did you dose 4mg to 6mg then 8mg?

Yes.

 

[desinr-gal]

We only have one study really that investigated the titration schedule, and they started one group at 1mg, one at 2mg, and even one at 4mg. Until it's actually released we don't have an official titration schedule. What we know is that the 4mg group lost weight faster, and on day 29 (after four weeks) they bumped up to 6mg/week.

Hunter Williams just did a Utube about latest studies results for Reta, comparing effects at many different doses.

here is the link to the study

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(25)00092-0/abstract

 

[kroert99]

Reta has been very slow for me! I didn't have any weight loss until I got to around 8 mg ( my current dose.) I have lost 17 lbs now. From what I've read, if you've done other weight loss peptides, then it doesn't work until higher doses. Personally I don't have much weight to lose ( max 20 lbs) so I expect that's not helping! Always harder to lose the last bit! I'd say to trust the process, follow the titration schedule and hope it works when you find your sweet spot.

Thank you for this. I started my glp-1 journey in 11/2022 and switched from sema to tirz and trying Reta cause I’ve plateaued for a year! My body seems happy but I’d love to lose at least 5 more pounds. I’m at 6mg Reta from amo and not feeling anything.

 

[dietpepsee]

I didn't have much luck on Mounjaro before - I got up to 7.5mg with only minimal weight loss. I am not a snacker really either, so I don't think I eat a ton. Probably just some metabolic damage from years of being heavy and trying to diet.

Did anyone else have trouble on Mounjaro and eventually have success on reta? I've been getting 10,000 steps a day, going to the gym a few times a week, and trying hard to limit my meals, which isn't that difficult since I finish half my plate and feel like I can't have any more. But I've only last about 3 lbs in my first month, and have started ramping up a bit more aggressively. I had a friend staying with me last month and he was on Mounjaro (his second month) and was down about 15 lbs. We ate pretty much the same meals for a month.

If anyone has been in a similar situation, where low doses didn't do much for them but higher doses did, I'd love to hear it. Thanks.

Reta is my first weight loss drug, started cautiously at 2mg and accelerated my dosage a little bit because I had little in the way of side effects and my weight wasn't budging much. I'm now at 6mg and it's made a huge difference in lowering my hunger level. I feel like I have the appetite of a human being again as opposed to a vacuum cleaner! It's exceeded my most optimistic expectations.

 

[desinr-gal]

I think titrating up quickly is the wrong way to go about it. The titration schedule was developed for a reason and the drug needs time to build up in your system. 3lbs/month is in the range of healthy weight loss. The only reason you're titrating up quicker is because of one thing - impatience. And impatience can be dangerous and unhealthy.

I mean, at the end of the day, you do you, but being at 8mg after a month is insane.

Thank you. I needed to hear this, as I am going very low and slow and getting impatient, so I started Reta in addition to the tirz very low there's no difference yet, but I was tempted to increase.

 

[Borromeo]

I’m SO glad I read this post because I’ve been starting to think I must be doing something wrong! I’ve been on Reta for seven weeks now with absolutely no weight loss or hunger abatement at all. Perhaps it’s because I don’t have a ton to lose (@155 lb hoping to get down to 135) but regardless, it is frustrating. I briefly tried Semaglutide a couple of years ago but I saw no loss at all on that either, so gave up on it after a couple of months. After trying (and failing) to drop the weight on my own for the past two years I finally decided to give Reta a try. My physician recommended a schedule that starts out pretty conservatively so that’s what I’ve been doing - but as mentioned before, at this point, I really haven’t seen any noticeable changes. I, too, walk daily (get approx. 12-13000 steps in) and will be starting a weekly strength training class in September. I hydrate well and eat fairly healthfully - small portions with low carbs, lean proteins, etc. Yet still nothing is budging! I am postmenopausal female, so I know that the weight loss battle is harder at this point in my life but I don’t think it is impossible. The schedule my doctor suggested had me on 0. 5mg/wk x4 then going up from there to 1-2-4-6-8-10-12 mg. Hoping to be conservative with this, so my plan is if I ever hit the “sweet spot”, I would stop titrating up there so as not to have to go all the way up to 12. As you can see below, I have increased the dosage somewhat quicker than recommended, but I’m still in a pretty low range. Should I stick with the 2mg I am currently on for the next two weeks or let my impatience get the best of me and increase it further up to 4mg for my next dose ? That is my current dilemma! I know, slow and steady wins the race. But I also know that I am at a pretty low dose and nothing seems to be happening. Also factor in an upcoming event later this fall that I would like to be at least be 10 pounds thinner for and you can understand my lack of patience! Reading this thread has been very helpful…. Really hoping to possibly glean more advice from those here who have already “been there and done that”.

1 Week - 0.5 mg - July 11

2 Week - 0.5 mg

3 week - 0.5 mg

4 Week - 1 mg

5 Week - 1.5 mg

6 Week - 2 mg

7 Week - 2 mg

 

[peptidepower77]

I’m SO glad I read this post because I’ve been starting to think I must be doing something wrong! I’ve been on Reta for seven weeks now with absolutely no weight loss or hunger abatement at all. Perhaps it’s because I don’t have a ton to lose (@155 lb hoping to get down to 135) but regardless, it is frustrating. I briefly tried Semaglutide a couple of years ago but I saw no loss at all on that either, so gave up on it after a couple of months. After trying (and failing) to drop the weight on my own for the past two years I finally decided to give Reta a try. My physician recommended a schedule that starts out pretty conservatively so that’s what I’ve been doing - but as mentioned before, at this point, I really haven’t seen any noticeable changes. I, too, walk daily (get approx. 12-13000 steps in) and will be starting a weekly strength training class in September. I hydrate well and eat fairly healthfully - small portions with low carbs, lean proteins, etc. Yet still nothing is budging! I am postmenopausal female, so I know that the weight loss battle is harder at this point in my life but I don’t think it is impossible. The schedule my doctor suggested had me on 0. 5mg/wk x4 then going up from there to 1-2-4-6-8-10-12 mg. Hoping to be conservative with this, so my plan is if I ever hit the “sweet spot”, I would stop titrating up there so as not to have to go all the way up to 12. As you can see below, I have increased the dosage somewhat quicker than recommended, but I’m still in a pretty low range. Should I stick with the 2mg I am currently on for the next two weeks or let my impatience get the best of me and increase it further up to 4mg for my next dose ? That is my current dilemma! I know, slow and steady wins the race. But I also know that I am at a pretty low dose and nothing seems to be happening. Also factor in an upcoming event later this fall that I would like to be at least be 10 pounds thinner for and you can understand my lack of patience! Reading this thread has been very helpful…. Really hoping to possibly glean more advice from those here who have already “been there and done that”.

1 Week - 0.5 mg - July 11

2 Week - 0.5 mg

3 week - 0.5 mg

4 Week - 1 mg

5 Week - 1.5 mg

6 Week - 2 mg

7 Week - 2 mg

In the trials one group started at 1mg, one at 2mg, and another at 4mg. Each of them titrated up roughly each month. So at this point, it's your decision, but if you aren't seeing results there's nothing wrong with titration up. If I were in your shoes I'd be moving up to 4mg at least for Weeks 8-11, and then 6mg from 12-15. I started basically at 4mg for the first month (like one of the trail arms did), and went up to 6mg for month two. I don't really feel any sides, so I'm not concerned. But I also don't have any real weight loss either, other than the 2-3 lbs I tend to keep losing and regaining. So I'll likely go up to 8mg at the 3 month mark.

My insulin has gone up and my liver enzymes as well. Nothing scary with either, but neither is normal. When I asked ChatGPT what it likely meant, it said quick mobilization of fat from the liver (which reta can do) can cause blips like that. So even if the weight isn't coming off, my labs show something is happening with the liver fat at least. So I'm hoping once that's cleared/reduced maybe weight loss picks up.

 

[mopo89]

I’m SO glad I read this post because I’ve been starting to think I must be doing something wrong! I’ve been on Reta for seven weeks now with absolutely no weight loss or hunger abatement at all. Perhaps it’s because I don’t have a ton to lose (@155 lb hoping to get down to 135) but regardless, it is frustrating. I briefly tried Semaglutide a couple of years ago but I saw no loss at all on that either, so gave up on it after a couple of months. After trying (and failing) to drop the weight on my own for the past two years I finally decided to give Reta a try. My physician recommended a schedule that starts out pretty conservatively so that’s what I’ve been doing - but as mentioned before, at this point, I really haven’t seen any noticeable changes. I, too, walk daily (get approx. 12-13000 steps in) and will be starting a weekly strength training class in September. I hydrate well and eat fairly healthfully - small portions with low carbs, lean proteins, etc. Yet still nothing is budging! I am postmenopausal female, so I know that the weight loss battle is harder at this point in my life but I don’t think it is impossible. The schedule my doctor suggested had me on 0. 5mg/wk x4 then going up from there to 1-2-4-6-8-10-12 mg. Hoping to be conservative with this, so my plan is if I ever hit the “sweet spot”, I would stop titrating up there so as not to have to go all the way up to 12. As you can see below, I have increased the dosage somewhat quicker than recommended, but I’m still in a pretty low range. Should I stick with the 2mg I am currently on for the next two weeks or let my impatience get the best of me and increase it further up to 4mg for my next dose ? That is my current dilemma! I know, slow and steady wins the race. But I also know that I am at a pretty low dose and nothing seems to be happening. Also factor in an upcoming event later this fall that I would like to be at least be 10 pounds thinner for and you can understand my lack of patience! Reading this thread has been very helpful…. Really hoping to possibly glean more advice from those here who have already “been there and done that”.

1 Week - 0.5 mg - July 11

2 Week - 0.5 mg

3 week - 0.5 mg

4 Week - 1 mg

5 Week - 1.5 mg

6 Week - 2 mg

7 Week - 2 mg

there is no reason to titrate up sooner, imo. titrating up sooner does not necessarily mean the weight will fall off quicker. but what it will mean is you'll get to max dose quicker, and be likely to burn out your receptors quicker. slow and steady wins the race. it's not really expected you'll lose weight at the lower doses (although some do), but the titration schedule is there for a reason (especially if you had a doctor assist you with one).

it could also mean reta isn't for you, but it's still probably a bit early. you've only been on the drug for less than 6 weeks. glp1s are not a miracle cure, and starting to take one with that mindset is going to set you up for disappointment (and i can confidently say this, because i thought starting sema would solve all of my weight problems.... and then i turned out to be a non-responder).

 

[Breezygyal]

Pretty slow burn for me. Lost about 7lbs in 6 weeks, if that continues, will probably = 8 lbs in 2 months. I'm happy with it, though. I started at like BMI 23.5, so I knew it would be slower for me if I want to preserve muscle. I am working out and seeing gains, seeing the roll under my bellybutton disappear, and overall noticing that I look leaner and more fit!

 

[BooneDonk]

I increased to 6mg yesterday from my every three days 3mg.

I think I’ll stay here for now. Trying to figure out if I can make myself eat 3oz of steak and an egg later. I bet I’m down a couple pounds tomorrow morning from Monday, didn’t weigh today. Crazy what the bump will do.

 

[desinr-gal]

I’m SO glad I read this post because I’ve been starting to think I must be doing something wrong! I’ve been on Reta for seven weeks now with absolutely no weight loss or hunger abatement at all. Perhaps it’s because I don’t have a ton to lose (@155 lb hoping to get down to 135) but regardless, it is frustrating. I briefly tried Semaglutide a couple of years ago but I saw no loss at all on that either, so gave up on it after a couple of months. After trying (and failing) to drop the weight on my own for the past two years I finally decided to give Reta a try. My physician recommended a schedule that starts out pretty conservatively so that’s what I’ve been doing - but as mentioned before, at this point, I really haven’t seen any noticeable changes. I, too, walk daily (get approx. 12-13000 steps in) and will be starting a weekly strength training class in September. I hydrate well and eat fairly healthfully - small portions with low carbs, lean proteins, etc. Yet still nothing is budging! I am postmenopausal female, so I know that the weight loss battle is harder at this point in my life but I don’t think it is impossible. The schedule my doctor suggested had me on 0. 5mg/wk x4 then going up from there to 1-2-4-6-8-10-12 mg. Hoping to be conservative with this, so my plan is if I ever hit the “sweet spot”, I would stop titrating up there so as not to have to go all the way up to 12. As you can see below, I have increased the dosage somewhat quicker than recommended, but I’m still in a pretty low range. Should I stick with the 2mg I am currently on for the next two weeks or let my impatience get the best of me and increase it further up to 4mg for my next dose ? That is my current dilemma! I know, slow and steady wins the race. But I also know that I am at a pretty low dose and nothing seems to be happening. Also factor in an upcoming event later this fall that I would like to be at least be 10 pounds thinner for and you can understand my lack of patience! Reading this thread has been very helpful…. Really hoping to possibly glean more advice from those here who have already “been there and done that”.

1 Week - 0.5 mg - July 11

2 Week - 0.5 mg

3 week - 0.5 mg

4 Week - 1 mg

5 Week - 1.5 mg

6 Week - 2 mg

7 Week - 2 mg

I stall when I dont workout. Weight lifting or hiking, etc. all those steps is very impressive! yet the body just seems to adjust, so changing it up and pushing harder seems to wake up the metabolism. There are so many free videos on you tube. You dont need a class, and can wear whatever you want.

Cronometer app (there is a free version) is great for tracking nutrition. I had no idea I wasnt getting enough of certain things until I did that! Good Luck!

 

[Mr. Blonde]

Losing 1-2 pounds per week or 4-8 per month is ideal for it being mainly fat and not muscle provided you are strength training and eating protein.

People that drop crazy amounts too quickly are usually in the beginning where a lot of it is water and inflammation weight or they aren't exercising and are losing an almost equal amount of fat and muscle which is awful.

Sounds like you are doing it right. Just stick with it. You didn't gain the weight overnight and aren't going to lose it overnight. Good luck

 

[keangkong]

Losing 1-2 pounds per week or 4-8 per month is ideal for it being mainly fat and not muscle provided you are strength training and eating protein.

People that drop crazy amounts too quickly are usually in the beginning where a lot of it is water and inflammation weight or they aren't exercising and are losing an almost equal amount of fat and muscle which is awful.

Sounds like you are doing it right. Just stick with it. You didn't gain the weight overnight and aren't going to lose it overnight. Good luck

I managed to lose 15 pounds of muscle while losing 50 pounds. In retrospect, it would have been better to lose more slowly.

I had above average muscle (according to my smart scale) before I began. (No, I never looked buff.) I am happy that I lost the weight. I now have normal muscle mass for my height, gender, and age. However, I want to regain at least 10 pounds of the muscle I lost. I won't look huge. But I'll be stronger than average.