Any grey peptides for migraine headache

[lessthanhalf]

I am taking tirzepatide 15 mg and started adding in reta a few weeks ago, was at about 4mg/week. ( I am trying to maintain a 50% weight loss ) Got two migraines in a row both starting at 5 or 6 am last week and then 7 days in a row this week, most starting early am . I have had migraines since forever but never this many in a short time. Eletriptan works well and quickly for me, but is not a great idea to take it every day for a week. Retatrutide is the only recent change I can think of that might have caused this, so I am stopping it for now and will see what happens. And maybe try restarting it slowly once they are gone. Bit of a pity as i have been losing 0.5kg a week the last few weeks, and only 450 grams to go to get to exactly half my start weight. I don't have any of the above mentioned peptides on hand to try, at this stage i would try almost anything to stop this burst of migraines.

 

[RubbaDubba1]

I have not found a peptide for migraines yet. I've tried many including ghkcu, glow, klow, ......The only med (prescription) that works for me without too many side effects is an old one probably no longer available with its original name of fioricet, fiorinal, still available in generic. No magnified migraine symptoms or nausea/vomiting. https://en.wikipedia.org/wiki/Butalbital/acetaminophen . They still manage to charge $$ but worth every penny penny for me.

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

 

[swimmer]

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

Thank you for the info. I have not tried cjc 1295 yet. I cycle Ipamorelin and tessamorelin. That combo definitely did not make migraines worse. The peptides that I have tried that seem to help are: glutathione, gck-cu, KPV. I cycle glutathione at 100mg per day with subq vitamin c. Either oral (1500mg/day) or sub q cut down frequency and intensity by more than 50% TB-500, bpc-157, 5amino1 made migraines worse. Especially 5-amino1.

 

[Labcat]

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

@RubbaDubba1 @swimmer @Jack brown and others, this is a fantastic thread and thank you and all who contributed. I’ve had lifetime migraines and since covid have been having migraines and other headaches more days than not even with neurology supervision of my medications (ajovy, nurtec, fioricet, propranolol), and then my migraines got significantly more intense on tirz (but others things got better so I kept upping my dose lol, thank goodness for aspirin and having saved up some fioricet). I’m coming off tirz now because it makes me too sleepy, physically weak, plus muscle loss, and unable to eat (with mild weight loss), but I’m going to try it again sometime now that I’m aware of peptides. I’ll try your great suggestions first. I just started ss31 a few days ago (and there is a lot of conjecture in the migraine literature that migraine is a mitochondrial disease) and so far it’s promising. If I can’t find this thread to report back, feel free to DM me if you want to know what happens.

I was told that by specialists at stanford a few years ago that they believe constant migraines cause cumulative brain injury. (They didn’t offer treatment and their clinic was too backed up and $$$$). So this is all very hopeful (edited for clarity)

 

[Not_Your_Dad]

Just to be contrarian to all of you fine folks, I had the exact opposite effect from tesamorelin.

I was about 6 weeks in to a cycle, and I woke up one night with a migraine. Not especially unusual for me - maybe I didn't have caffeine late enough, maybe my CPAP was whack, whatever. That was a Wednesday. Happened again on Thursday, but worse. Woke up on Friday around 3:30a with such an intense migraine I was considering going to the Emergency Room.

I then realized that, for the past week, I had little itchy spots on my abdomen. Also not terribly unusual, but then it dawned on me, they were where I had pinned my 2mg tesamorelin dose in the PM. I seemed to be having an escalating histamine response to it. I stopped taking the tesa, and the migraine went away the very next night. I was pinning CJC1295 no-dac and Ipamorelin at the same time (I was really just after the Ipa, but my vendor didn't have a Tesa/Ipa blend in stock at the moment). I've continued the CJC/IPA, but dropped down to just an AM pin. I may return to the evening pin as well just to see.

Anywho, that's my story with Tesamorelin and migraines. I don't know that I'll be returning to my tesa cycle after this experience!

 

[swimmer]

Just to be contrarian to all of you fine folks, I had the exact opposite effect from tesamorelin.

I was about 6 weeks in to a cycle, and I woke up one night with a migraine. Not especially unusual for me - maybe I didn't have caffeine late enough, maybe my CPAP was whack, whatever. That was a Wednesday. Happened again on Thursday, but worse. Woke up on Friday around 3:30a with such an intense migraine I was considering going to the Emergency Room.

I then realized that, for the past week, I had little itchy spots on my abdomen. Also not terribly unusual, but then it dawned on me, they were where I had pinned my 2mg tesamorelin dose in the PM. I seemed to be having an escalating histamine response to it. I stopped taking the tesa, and the migraine went away the very next night. I was pinning CJC1295 no-dac and Ipamorelin at the same time (I was really just after the Ipa, but my vendor didn't have a Tesa/Ipa blend in stock at the moment). I've continued the CJC/IPA, but dropped down to just an AM pin. I may return to the evening pin as well just to see.

Anywho, that's my story with Tesamorelin and migraines. I don't know that I'll be returning to my tesa cycle after this experience!

I had to drop to 1mg per day for the Tesa in the ipa/Tesa stack. It increased my heart rate and I retained water like crazy on 2mg.

 

[Labcat]

I’ve recently heard numerous reaction stories with tesa, it sounds like the reaction could have been driving your migraine? If it was histamine, it could have definitely potentiated migraine by causing inflammation and blood vessel dilation.

 

[deleted.user.16]

@RubbaDubba1 @swimmer @Jack brown and others, this is a fantastic thread and thank you and all who contributed. I’ve had lifetime migraines and since covid have been having migraines and other headaches more days than not even with neurology supervision of my medications (ajovy, nurtec, fioricet, propranolol), and then my migraines got significantly more intense on tirz (but others things got better so I kept upping my dose lol, thank goodness for aspirin and having saved up some fioricet). I’m coming off tirz now because it makes me too sleepy, physically weak, plus muscle loss, and unable to eat (with mild weight loss), but I’m going to try it again sometime now that I’m aware of peptides. I’ll try your great suggestions first. I just started ss31 a few days ago (and there is a lot of conjecture in the migraine literature that migraine is a mitochondrial disease) and so far it’s promising. If I can’t find this thread to report back, feel free to DM me if you want to know what happens.

I was told that by specialists at stanford a few years ago that they believe constant migraines cause cumulative brain injury. (They didn’t offer treatment and their clinic was too backed up and $$$$). So this is all very hopeful (edited for clarity)

I do not have DM permissions but plz do let me know what happened! I am also suffering from chronic daily migraines (going on 13 years now) and am looking to all avenues for solutions.

 

[Makoto]

Ghk-Cu helps with migraines? Good to know and thank you all on this thread from mentioning it, i suffer from migraines from time to time (and they hit HARD). Makes me wish that i got Klow instead of bpc+tb (which i'm currently using), since it seems like it would target most of my issues, lol.

 

[deleted.user.16]

Ghk-Cu helps with migraines? Good to know and thank you all on this thread from mentioning it, i suffer from migraines from time to time (and they hit HARD). Makes me wish that i got Klow instead of bpc+tb (which i'm currently using), since it seems like it would target most of my issues, lol.

I looked into KPV for migraines based on that infamous baseball cap dude, but from a brief scraping of the Reddits it seems more people say it causes headaches for them than cures them. Still might give it a go just because I don't have any other options.

 

[mtomm]

I'm looking for this as well and not much has looked promising for migraines. It seems everyone has different experiences.

 

[birdwhacker]

Have you tried drinking a large dose of electrolytes in the morning? Research shows that the vast, vast majority of migraine headaches can be effectively treated with hydration + electrolytes.

I drink a tall glass of very salty water mixed with potassium every morning and it helps me tremendously. Just table salt + nosalt from the store in a rough 1:3 ratio, not as salty as ocean water but salty enough that it doesn't just taste weird but is noticably salty.

Obviously you want to follow up with more water later.

 

[deleted.user.16]

Have you tried drinking a large dose of electrolytes in the morning? Research shows that the vast, vast majority of migraine headaches can be effectively treated with hydration + electrolytes.

I drink a tall glass of very salty water mixed with potassium every morning and it helps me tremendously. Just table salt + nosalt from the store in a rough 1:3 ratio, not as salty as ocean water but salty enough that it doesn't just taste weird but is noticably salty.

Obviously you want to follow up with more water later.

Thanks for the tip. I've seen the research on magnesium and migraines and I already take magnesium in pill form but I can't really tell if it's done anything. Though I often forget to take it so I can't say for sure. I'll try electrolytes with potassium, just gotta remember to do it every morning lol.

Edit: whoops, sorry if you were responding to mtomm

 

[birdwhacker]

Thanks for the tip. I've seen the research on magnesium and migraines and I already take magnesium in pill form but I can't really tell if it's done anything. Though I often forget to take it so I can't say for sure. I'll try electrolytes with potassium, just gotta remember to do it every morning lol.

If you don't have potassium, just use plain salt in water. Most electrolyte drinks don't have enough to do anything besides basic rehydration in my opinion, coconut water based drinks usually have 800+mg of potassium in a serving, but the RDA is 4.5g

Like I said, I don't get migraines, but this little trick has definitely changed my life by increasing ny hydration and curing my heartburn. I started with just salt until I learned about the potassium balance.

Good luck! I have a buddy that suffered migraines, him and his sister, both of them were chronically dehydrated and refused to try this trick. He maintains that opiates were the only thing for it LOL

 

[deleted.user.16]

If you don't have potassium, just use plain salt in water. Most electrolyte drinks don't have enough to do anything besides basic rehydration in my opinion, coconut water based drinks usually have 800+mg of potassium in a serving, but the RDA is 4.5g

Like I said, I don't get migraines, but this little trick has definitely changed my life by increasing ny hydration and curing my heartburn. I started with just salt until I learned about the potassium balance.

Good luck! I have a buddy that suffered migraines, him and his sister, both of them were chronically dehydrated and refused to try this trick. He maintains that opiates were the only thing for it LOL

I already tried opiates and didn't do a damn thing besides make me dizzy and want to throw up. If black market opiates worked I'd be taking them every day.

 

[Labcat]

The ghkCu works for me to prevent migraines and make them less intense. I take it with ghk basic (basic does not do any for the migraines) and kpv (kpv does not help my migraines) to decrease the isr. I had to stop a while because the isrs were getting out of hand and I was running out of places to pin, and I miss it.

 

[RubbaDubba1]

I looked into KPV for migraines based on that infamous baseball cap dude, but from a brief scraping of the Reddits it seems more people say it causes headaches for them than cures them. Still might give it a go just because I don't have any other options.

I'm right in the middle of this, with my shoulder surgery I had 4 weeks ago and physical therapy I'm doing now FFFF! I'm having back & neck spasms, while he's trying stretch my arm out Uggh! Anyways, I'm up to 500mcg each of CJC-1295 no dac/IPamorelin everyother day, when I have PT. It's not perfect, but I feel like it keeps the headaches under control. I'm just making the case for the Secretagogues again, the Ipamorelin is most of it for me.

 

[Labcat]

I already tried opiates and didn't do a damn thing besides make me dizzy and want to throw up. If black market opiates worked I'd be taking them every day.

It’s really annoying that opiates don’t work for migraines.

I’m going to put in a plug for those new migraine meds like amovig, ajovy, and rimegepant for migraines. They are Rx and aren’t perfect with known limitations but they are life changing for many and often doctor’s offices have free samples and mfg coupons. I have seen rimegepant available on those India pharmacy lists

 

[lessthanhalf]

Just a quick plug for more standard therapies for migranes, as there are a lot and a lot of people do not know what options exist.

For acute migranes either elitriptan or ibuprofen are both extremely effective,, unfortunately does not mean they will work for everyone or every time, but success rates are very high, eletriptan has the highest initial success rate and ibuprofen has the highest success rate at no pain 24 hours later. Both are more effective than the newer Calcitonin gene-related peptide drugs though they can be useful if nsaids or tryptans are not working. Opiates can work but are avoided as much as possible due to addiction risks and they can make migranes worse or trigger them.

For frequently recurring migranes, preventive therapy is usual, and is fairly standard general practice medicine or if severe, frequent and disabling neurologists are the go. None of the peptides have any science at all of working in humans for migrane, and there are a lot of fairly effective medical treatments out there, although sometimes it can take a trial of a few different drugs to find what works best. And there are a few unlucky people who do not seem to respond well to multiple trials of medications or even botox.

 

[Labcat]

Just a quick plug for more standard therapies for migranes, as there are a lot and a lot of people do not know what options exist.

For acute migranes either elitriptan or ibuprofen are both extremely effective,, unfortunately does not mean they will work for everyone or every time, but success rates are very high, eletriptan has the highest initial success rate and ibuprofen has the highest success rate at no pain 24 hours later. Both are more effective than the newer Calcitonin gene-related peptide drugs though they can be useful if nsaids or tryptans are not working. Opiates can work but are avoided as much as possible due to addiction risks and they can make migranes worse or trigger them.

For frequently recurring migranes, preventive therapy is usual, and is fairly standard general practice medicine or if severe, frequent and disabling neurologists are the go. None of the peptides have any science at all of working in humans for migrane, and there are a lot of fairly effective medical treatments out there, although sometimes it can take a trial of a few different drugs to find what works best. And there are a few unlucky people who do not seem to respond well to multiple trials of medications or even botox.

Agree that standard therapies can be helpful, though in my experience, medical providers often rely on the basics without moving patients forward and running through the known things that help (avoiding triggers, aspirin, caffeine, nsaids. beta blockers, tryptans). But having said that, many of these standards do not help enough or have contraindications. Aspirin was fairly helpful for me but it turns out that a significant portion of people experience significant bleeding or anemia, and I was one of them. I am in the group that thinks fioricet works, though unfortunately many subscribe now to current thinking that it does not, due to one study. Botox works for some, even not injected into the trigger muscles. So can lidocaine (I see it offered everywhere for research but you all need to remember that lidocaine is a cardiac medication, and people have died in those spas)

Anyhow, my neurologist is of the opinion that the CGRPs can be safer and more effective, especially if one has other medical issues… but insurance still demands that you fail a trial of several other meds before going to the new ones (expensive because of big pharma) He reminded me that you have to fill the meds to document having trialed them but failing a trial includes rains such as not ingesting the medication.

Find a headache expert who is open minded, listens to patients, and has experience using the meds, not just beliefs about the meds. And have them help you through your personal specifics.

Migraines cause brain issues due to lack of oxygen, and current thinking also is that this causes long term permanent consequences other than days of pain, which is bad enough.