我到底在干什么？

[FilterOrDeath]

Not surprising that someone with practical lab experience is a proponent . I have all the materials and just did it for the first time last week. Now I would consider myself relatively competent in most things. I can read, digest and apply. Background in electronics now working in water quality. I thought it went okay, only wasted one needle and one barrel by not following procedure. Should be smoother next time.

That being said after my first experience filtering if you were to do some type of meta analysis of everyone out there reconstituting their own peps, I'm pretty confident that we are probably doing more harm than good. Just the sheer amount of additional supplies , each one is another "point of failure". So on the assumption of a suspect vial I'm going to count on my technique and expertise as well as assuming the sterility of each additional component is "good" while assuming my peptide vial is "bad". That seems like a poor assumption. Especially with my technique and expertise which is extremely lacking.

If I had years of sterile lab technique experience and training, filtering would be automatic. For the rest of us I think it is much more nuanced. I will continue to use up all the supplies that I currently have but will I continue after that? Probably not, unless @IshimaruKenta comes down with dysentery again.

Hahahah we are all waiting to see how that Oregon Trail dysentery situation plays out!

Okay adding a real response now that I'm done laughing about dysentery. Maybe I do underestimate how complicated it is for people that haven't worked in those lab environments before, that's hard to determine honestly. I think I assumed with all the people using pens and already doing all those steps I thought it was a pretty common practice. I'm good with being wrong though. And I agree with you that filtering isn't going to be a great option for everyone unfortunately. I think that's part of the reason I'm curious about why people do or don't and I don't judge them either way. I know there could be cost restraints, existing environmental/air quality issues, mobility issues, fear of needles, and more that could make it not viable for everyone. Also, skill and comfort level are important factors. So I am glad to see the little filtering kits are available so people can try it, if they want too, and see if it's a hard pass before buying boxes of 100 of all the things. If someone has the information, pros and cons of both sides, and doesn't want to filter that's good with me.

Question for you if you don't mind answering. If you were going to start using pens and doing all of those steps and using the different needles etc, creating the multiple points of failure, would you go ahead and do the filtering then?

 

[Calm Logic]

If you were going to start using pens and doing all of those steps and using the different needles etc, creating the multiple points of failure, would you go ahead and do the filtering then?

Yes. Good point:

If a stray skin cell or dust mite enters the stream during the transfer, the filter stops it before it sits in a pen at room temperature for weeks.

A 0.22-micron filter becomes a mandatory 'toll booth' to catch the domestic pathogens you’ve inevitably introduced.

 

[yrrdead]

-Snip

Question for you if you don't mind answering. If you were going to start using pens and doing all of those steps and using the different needles etc, creating the multiple points of failure, would you go ahead and do the filtering then?

I had a larger post but I think we are hijacking this thread from whatever the heck it was originally about .

 

[Chili777]

It's a nice write up of the interview, but note that he says there are likely 2 sources for Reta (one of the newer and more complex peptides). His explanation make sense too, that it's all about the cost efficiency of an established manufacturing process. The older, rarer, and just less complex peptides (eg GHK-Cu) likely have many more manufacturers, as do Sema, and likely Tirz. A chemist can call a number of different raws manufacturers in China (who may also lyophilize) to manufacture small volume peptides (

 

[FarmgirlRebel]

Yes we are. Just a simple Google search will give you several companies in CN that manufacture for the two big GLP companies. Many of the CN companies were started with venture capital money from the US big pharma industries . It’s a fact.

This is why we wont go to war or have any "real" trade war with China. The US and a lot of EU countries are over a pharmaceutical barrel. China manufactures between 70-80% of all US pharmaceuticals

 

[ComputerElbow]

其实，我最初是从我的健身教练那里听说瑞塔的。但我只跟我妻子透露了整个GLP-1治疗过程。

我也是从健身房的一个哥们儿那里听说的。我好几个月没见他了，我们一起吃了顿饭，他瘦得跟我以前见过的任何朋友都不一样。他跟我说了他用的是什么，我一时冲动就从他那儿买了几瓶。

我当时抱着“开火、瞄准、准备”的心态……现在算是赶上进度了。

 

[Bcnlvr]

我们医疗部门也是这样。我觉得我们科室超过一半的人都在服用微剂量药物。

 

[Turbo-Farmer]

我在制药行业工作。不是肽类药物，而是抗体，负责灌装和包装。我以前也做过这类药物的大批量生产。我了解实际成本和极高的利润率。

随着我的代谢健康状况开始恶化，我的家庭医生建议我使用替拉帕肽，但我的保险要等到我病情加重才能报销，所以我开始尝试配制药物，这符合健康储蓄账户（HSA）的报销条件，但现在大型制药公司搞的那些恐吓策略也让配制药物岌岌可危。所以最近我开始囤积灰色药物。