Reta X Cagrilintide

[lessthanhalf]

Been on 8mg reta pw for six months with zero weight loss, and increased hunger/appetite. Just started cagri to help reduce food noise so I can function day to day without daydreaming about food. 250mcg - nothing. 500mcg - still nothing. Wondering if I should just do 1mg.

Just wondering why you have not gone up to 12mg of reta? Side effects? I thought that the small unfortunate percentage of people who lost little weight with GLP's usually got very few side effects, going on the fact that the circuits that cause nausea etc are pretty much the same ones that reduce appetite. So really zero weight loss with 8mg of reta. Ouch. I cannot see any reason not to try 12mg , though if you have had no response so far the odds are not great. Do you have a lot of weight to lose? diabetic? Any chance your batch of reta is no good?

And if cagri is not causing side effects then it has been studied up to 2.4mg so no reason not to keep on increasing , though a lot of people are pretty sensitive to small increases so maybe 0.75 for a couple of weeks first before 1mg. If you still get zero effect from 12mg of reta, tirz might be worth trying, the odds of responding to it after not responding to reta are not great, but it is by far the strongest on GIP, just maybe your system might be more sensitive to that incretin, even if so far it is not responding much to GLP-1 or glucagon or amylin.

 

[RadicalCrimson]

After maxing out Tirz then Reta, I ramped up on Cagri using the study protocol:

4 weeks at 0.25mg

4 weeks at 0.5mg

4 weeks at 1mg

4 weeks at 1.7mg <== I am still here

Maintenance at 2.4mg <== I am not there

It worked fine, no side effects and I reached weight goal now.

 

[lessthanhalf]

After maxing out Tirz then Reta, I ramped up on Cagri using the study protocol:

4 weeks at 0.25mg

4 weeks at 0.5mg

4 weeks at 1mg

4 weeks at 1.7mg

 

[miameow]

Just wondering why you have not gone up to 12mg of reta? Side effects? I thought that the small unfortunate percentage of people who lost little weight with GLP's usually got very few side effects, going on the fact that the circuits that cause nausea etc are pretty much the same ones that reduce appetite. So really zero weight loss with 8mg of reta. Ouch. I cannot see any reason not to try 12mg , though if you have had no response so far the odds are not great. Do you have a lot of weight to lose? diabetic? Any chance your batch of reta is no good?

I've been on each dose for 4 weeks before titrating up by another mg. I jumped from 6mg to 8mg this week because I wanted to see if I was really reta resistant. I experience all the side effects, without the benefits. I am freezing cold in June and have all the pleasure of the GI discomfort. I won't be able to survive beyond 8mg.. there's no way I would even do another week on 8mg.

Yes, really, zero weight loss! I don't really want to go up to 12mg when it doesn't work for me at 8mg. I have maybe about 5-10lbs to lose. Not overweight and not diabetic. Just have some stubborn midlife crisis weight I want to drop.

My reta was tested independently for m/p/e. It is overfilled. I filter. So it's real and it works on everyone else but me. I know it's hard to believe, but it is what it is I guess.

And if cagri is not causing side effects then it has been studied up to 2.4mg so no reason not to keep on increasing , though a lot of people are pretty sensitive to small increases so maybe 0.75 for a couple of weeks first before 1mg. If you still get zero effect from 12mg of reta, tirz might be worth trying, the odds of responding to it after not responding to reta are not great, but it is by far the strongest on GIP, just maybe your system might be more sensitive to that incretin, even if so far it is not responding much to GLP-1 or glucagon or amylin.

I actually pinned another 500mcg of cagri right after I wrote that, totaling 1mg. I felt no difference at all. I was going to try tirz next actually if cagri doesn't work. I'll pin another 1mg of cagri tomorrow and meanwhile source some tirz. I'm also considering survo or maz.

 

[lessthanhalf]

I am not suggesting your problem is not a problem but with not a lot of weight to lose it is annoying rather than devastating, and without severe health consequences. If after looking at the research for 30+ years and they finally made anti obesity drugs that worked but I did not respond I would be pretty upset, but I had a lot of weight to lose.

Most of the less overweight people on this forum have responded quite well to low doses of reta. The only ones I know of that did not respond tended to have more severe obesity often with diabetes. There is known genetic variation in the incretin receptors that can influence response to them, but a bit unlucky not to have a response to 4 different ones, assuming cagri does not start working at higher doses.

 

[RadicalCrimson]

Out of interest how much weight did you lose?

33% of my starting weight. I only added cagri at the last 15 lbs or so, to stop the yo-yoing and resume loss.

 

[lessthanhalf]

It is such a pity the only real studies so far combining GLP like drugs was cagrisema, which was not really that good, mainly because semaglutide is just not as effective as tirz or reta. And cagri on its own was disappointing to the point where they have not tried to get it approved as a drug on its own yet. But there do seem to be quite a few people adding in cagri to tirz or reta and getting additional weight loss, past the 30% mark. Will be interesting to see how well eloralintide works as an add on once it gets a bit cheaper and more available. Reta and eloralintide is possibly the new state of the art at least in theory for huge weight loss, might get very close to surgery without the surgery part.

 

[miameow]

I am not suggesting your problem is not a problem but with not a lot of weight to lose it is annoying rather than devastating, and without severe health consequences. If after looking at the research for 30+ years and they finally made anti obesity drugs that worked but I did not respond I would be pretty upset, but I had a lot of weight to lose.

Most of the less overweight people on this forum have responded quite well to low doses of reta. The only ones I know of that did not respond tended to have more severe obesity often with diabetes. There is known genetic variation in the incretin receptors that can influence response to them, but a bit unlucky not to have a response to 4 different ones, assuming cagri does not start working at higher doses.

Unfortunately, it is quite devastating for me. I started it because my family has a history of developing diabetes at an older age and subsequently dying from complications, despite having a below-average BMI. I am not diabetic yet, but I want to avoid going there, which is why I started reta right after my father's death and stayed on it for six months despite no progress. I am as desperate as, if not more than, anyone that has more weight to lose.

The studies show that compounds do work, but not on everyone. There is no medicine that works on 100% of the population.

 

[zpped]

Unfortunately, it is quite devastating for me. I started it because my family has a history of developing diabetes at an older age and subsequently dying from complications, despite having a below-average BMI. I am not diabetic yet, but I want to avoid going there, which is why I started reta right after my father's death and stayed on it for six months despite no progress. I am as desperate as, if not more than, anyone that has more weight to lose.

The studies show that compounds do work, but not on everyone. There is no medicine that works on 100% of the population.

Have you been tracking your A1C?

 

[lessthanhalf]

I did attempt to say that in a way that was intended to be non offensive and apologies if I got it wrong. Same question I was going to ask about hb1ac . It may still reduce glucose without reducing weight. They are one of the most effective medications for dropping hb1ac, and work well in diabetes even though they are less effective for weight loss in that case.

 

[miameow]

Have you been tracking your A1C?

Yes, I am tracking it due to family history. It is normal; I'm not diabetic or pre-diabetic, according to my doctor.