Reta results

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I lost visible muscle and lost strength during exercise but now that that I have been off for a few weeks my strength is starting to creep back in. Are you having the same issue?
 
mlke6 said:
are you having the skin sensitivity issues?
I can take no more than 6mg/week or I get terrible allodynia all over. I now pin 2mg every 3rd day and this gives me decent results. I wouldn’t mind taking more, as I’m only losing about .25lbs/week, but I don’t have much left to lose and I have to keep the allodynia at bay because it’s horrible and keeps me awake all night.
 
chelsea daggerz said:
I can take no more than 6mg/week or I get terrible allodynia all over. I now pin 2mg every 3rd day and this gives me decent results. I wouldn’t mind taking more, as I’m only losing about .25lbs/week, but I don’t have much left to lose and I have to keep the allodynia at bay because it’s horrible and keeps me awake all night.
My friend had the same, only when she started taking it and it went away with in a week. She is now at 5mg a week with no problem
 
I started in October and am down 30 pounds. I try my best to follow the dosing schedule of the clinical trials. Just hit 8mg but that is rough. Sulphur burps and diarrhea bad. This week I'm splitting to 4mg twice a week.
 
Radxpro43 said:
I started in October and am down 30 pounds. I try my best to follow the dosing schedule of the clinical trials. Just hit 8mg but that is rough. Sulphur burps and diarrhea bad. This week I'm splitting to 4mg twice a week.
I’ve never had sulphur burps on Reta, but with Sema they were really bad for me. Just the all around indigestion was bad, I couldn’t take it. I had great weight loss with Tirz, but the anhedonia was bad and I just had no energy, so I lost about 25 pounds with that and stopped taking it. I’ve had great results with Reta and my only issue is the severe skin sensitivity. I had about 40 lbs to lose overall and I’m about 10 away from my goal now. It’s very slow to come off, but I’m also trying to recomp, so trying to get enough protein in to keep the muscle mass and lean out a bit. Slow and steady wins the race. My goal is to get there by the middle of May which I think is realistic for me.
 
chelsea daggerz said:
I’ve never had sulphur burps on Reta, but with Sema they were really bad for me. Just the all around indigestion was bad, I couldn’t take it. I had great weight loss with Tirz, but the anhedonia was bad and I just had no energy, so I lost about 25 pounds with that and stopped taking it. I’ve had great results with Reta and my only issue is the severe skin sensitivity. I had about 40 lbs to lose overall and I’m about 10 away from my goal now. It’s very slow to come off, but I’m also trying to recomp, so trying to get enough protein in to keep the muscle mass and lean out a bit. Slow and steady wins the race. My goal is to get there by the middle of May which I think is realistic

chelsea daggerz said:
I’ve never had sulphur burps on Reta, but with Sema they were really bad for me. Just the all around indigestion was bad, I couldn’t take it. I had great weight loss with Tirz, but the anhedonia was bad and I just had no energy, so I lost about 25 pounds with that and stopped taking it. I’ve had great results with Reta and my only issue is the severe skin sensitivity. I had about 40 lbs to lose overall and I’m about 10 away from my goal now. It’s very slow to come off, but I’m also trying to recomp, so trying to get enough protein in to keep the muscle mass and lean out a bit. Slow and steady wins the race. My goal is to get there by the middle of May which I think is realistic for me.
What mg are you running
 
I’ve officially completed weight loss into recomp, and now going into bulk where I’ll titrate down from 4mg 2x/wk, to 1-1.5mg 2x/wk for maintenance.

Start 9/2/25 initial weight loss that went into recomp/cut

End 1/12/26

255-207lbs. Friday morning.

Tried to hit 2000 cals even though it was hard af just getting my g/lbs of protein. That was the key for me. Being in a huge deficit at least getting as close to that as possible which sucked when I was 250 lbs lol. Also, staying hydrated was huge. As the doses got higher hypo sides would come in. Always had a bag of trail mix with me during the day.

Now for 12 weeks I will go down 3mg 2x/wk for 2 weeks, then 2mg 2x/wk for 2 weeks and end somewhere between 1-1.5mg 2x/wk to try and bulk and build back some muscle. Hopefully my bg markers stay in tact as they’ve been awesome at 8mg/wk lol. Would like to get somewhere in the range if 220-225 before next cut.. beginning of April.

What a journey it’s been. Reta has changed my life and guided me to not only being in tune with my body, but health and dieting right. Now during bulk I’m upping calories from 2000-3000. Tried it out today. Fell short lol. Was full af by early afternoon. Settled for a protein shake early evening and still fell short by 300 cals!

Notable supplements that worked for me. Psyllium Husk (10g), NAC (1800mg), Magnesium Glycinate (410mg), l-citrulline (6-8g), l-carnitine (3-5g)
 
MrBMG said:
I’ve officially completed weight loss into recomp, and now going into bulk......

Tried to hit 2000 cals even though it was hard af just getting my g/lbs of protein. ........

What a journey it’s been. Reta has changed my life and guided me to not only being in tune with my body, but health and dieting right. Now during bulk I’m upping calories from 2000-3000. Tried it out today. Fell short lol. Was full af by early afternoon. Settled for a protein shake early evening and still fell short by 300 cals!
Yep. 62 y.o., male. 6/2/25, sw, 232. I hit gw of 188 on 10/27. My intent was and continues to be to bulk muscle back up to the 195 - 200 range and .... I have not been able to accomplish that. lol I'm not even using reta. I've been using 7.5 tirz and 1.8 survo since 10/17 and maintaining current weight range of 185-188 is pretty much effortless. However, because I have serious cardio concerns (atherosclerosis and just received a stent) and because I have an ortho/cervical issue at C5-C6 that I am currently trying to resolve, I am leery to titrate down now that I have my lipids/A1c/healthy food intake/weight management/moderate exercise basically on autopilot. I have tried to increase my kcal from 1800-ish to above 2500 and it is really hard to do - especially the 1g protein/1 lb of body weight.

🙂

At least we're able to actually work on these things today. I am super grateful for that instead of being beaten by the seeming alternative.
 
chelsea daggerz said:
I’ve never had sulphur burps on Reta, but with Sema they were really bad for me. Just the all around indigestion was bad, I couldn’t take it. I had great weight loss with Tirz, but the anhedonia was bad and I just had no energy, so I lost about 25 pounds with that and stopped taking it. I’ve had great results with Reta and my only issue is the severe skin sensitivity. I had about 40 lbs to lose overall and I’m about 10 away from my goal now. It’s very slow to come off, but I’m also trying to recomp, so trying to get enough protein in to keep the muscle mass and lean out a bit. Slow and steady wins the race. My goal is to get there by the middle of May which I think is realistic for me.
Do you mind sharing your current dosage? And your dose escalation over time? I'm fighting seriously bad anhedonia on tirz right now and considering trying reta instead
 
om777 said:
Do you mind sharing your current dosage? And your dose escalation over time? I'm fighting seriously bad anhedonia on tirz right now and considering trying reta instead
Right now my Reta dose is 2mg every 3rd day. So for example if I take 2mg on Monday my next 2mg dose will be Thursday, and so on. I cannot take anymore than that at a time or I get systemic allodynia and it’s pretty intense-especially when it’s cold 😵‍💫 I started out at 2mg for about 3-4 weeks then began to titrate up 1mg every 2 weeks or so. That’s when I began to notice the skin sensitivity-at 3mg-but it wasn’t bad enough to continuously bother me. When I began taking more it started to increase and I didn’t really put 2 and 2 together until I got to about 5mg. I kept going tho, because from what I could gather from others experiencing the same issue, it seemed to subside for them within a month or so. That never happened for me. It continued and was interfering with my ADLs and my sleep. That’s when I began 3mg 2x/week. That helped but I was still experiencing sensitivity, so I knocked it back to 2 and that’s when it subsided for the most part. I still get a slight bit of it now and again but it’s mild and doesn’t bother me that much.

I feel for you with Tirz and the anhedonia. The weight loss for me was good, but it made me feel like doing nothing. I would struggle just to get out of bed and getting to the gym took every bit of energy I had in me. I’ve tried to keep my weight loss journey slow and steady. Losing weight too quickly increases muscle loss and also sagging skin. That’s one of the reasons Reta has been better for me. I’m not dropping weight like crazy on it and I have absolutely no issues with decreased energy or anhedonia of any kind. The food noise is not as muted on Reta as it was with Tirz, but that’s not a huge deal for me. It’s been more to do with quantity for me. I can eat a ton of food 🤣 It used to take a lot for me to feel satiated. I have a degree in nutrition and dietetics, so it was never me not understanding portions or calories or even eating healthy. It’s always been just the sheer volume I can consume. Eating whole foods , very little processed, tracking absolutely everything and still was struggling. I had never really had an issue with weight and eating until I became pregnant with my first son, so I do believe that pregnancy changed something in me.

Anyway, I would definitely recommend switching to Reta if you’re able. The issues I had with Tirz, and what sounds like you’re having, was/is no way to live.
 
Gonna give Reta another shot. If it doesn’t work this time I’ll do a 6 week washout and start over I guess. I power titrated up to 4mg and will level off here. 2mg-3mg-4mg in three weeks
 
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