Reta (+Cagri) stopped working

[lessthanhalf]

My guess is that eventually once more research is done, higher doses will be considered ok for people with less than average responses and low side effects, not going to help people whose dose is limited by side effects. The only ones done so far are for semaglutide at 7.2mg and at 16 mg , with a bit of extra weight loss and a lot more side effects. The tirzepatide higher dose study is ongoing but there is zero information about it. Much more interesting would be if you take the 10 or 20 percent of people with low weight loss and not much side effects and study what higher doses does in that group, it will probably get done eventually, but not likely anytime soon. I suspect you could get better results but the only info so far is anecdotal online, which is interesting but not really a reliable data source.

 

[tubby]

Lots of good ideas here, but nobody offered the most obvious one:

If tesa is cranking up your GH production, that could cause you to increase your muscle mass. It's entirely possible that you're still losing fat, but the scale itself isn't moving because your lean mass is increasing. Otherwise, I think lessthanhalf hit all the other obvious angles here.

 

[lessthanhalf]

I saw this on a previous post with similar issues where there was a graph of weight over time and weight loss was progressing very steadily then went dead flat after hgh modifying drugs were added. So if there is a record or graph of what weight did over time it might help answer what is going on. If weight loss gradually slowed to zero, probably just less sensitive than average to the weight loss effects of reta/cagri , if there was consistent weight loss that suddenly stopped after tesa was started , that would be a bit of a giveaway as to the cause.

 

[RadicalCrimson]

I am wary about systemic reactions:

Epi Pen resources?

Has anyone managed to buy some Epi Pens as a hedge against potential anaphylaxis? If so, what was your process? Is there a go-to telehealth that can issue a scrip?

glp1forum.com

Now you scared me about all those CJC allergic reactions, even after prolonged use.

If the idea is just to "keep the oven warm" about GH pulsing alongside Ipa on the days alternating with Tesa, Sermorelin seems much safer, doesn't it?

 

[Calm Logic]

Now you scared me about all those CJC allergic reactions, even after prolonged use.

If the idea is just to "keep the oven warm" about GH pulsing alongside Ipa on the days alternating with Tesa, Sermorelin seems much safer, doesn't it?

Sermorelin is certainly safer/milder in general as far as affecting IGF-1.

Just for relative comparison (since individual results vary greatly, especially with males having more response):

Estimated IGF-1 Response Comparison

Baseline IGF-1: 187 ng/mL

Substance Dose Est. % Increase Est. Point Rise Projected IGF-1 Sermorelin 250 mcg 5–10% +10–20 197–207 Sermorelin 500 mcg 10–20% +20–40 207–227 Sermorelin 1000 mcg (1mg) 15–25% +30–50 217–237 Tesamorelin 1 mg 30–50% +60–90 247–277 Tesamorelin 2 mg (FDA dose) 50–100% +100–180 287–367 HGH 1 IU 40–70% +75–130 262–317 HGH 2 IU 80–120% +150–220 337–407 HGH 3 IU 120–180% +220–330 407–517

As far as immune reaction, it seems better than tesa and better than ipa w/ CJC:

In clinical trials for Geref (brand name Sermorelin), about 17% of patients developed anti-GRF antibodies. Most were asymptomatic, but systemic redness and urticaria (hives) were documented. While 17% developed antibodies, the studies noted that these antibodies often disappeared on their own and did not cause "generalized allergic reactions

The number of patients who developed antibodies to Tesamorelin (Egrifta) in clinical trials is surprisingly high—nearly 50% . In trials, 60% of patients who developed antibodies to Tesamorelin also developed antibodies that attacked their body's natural GHRH.

Ipamorelin w/ CJC would probably be in between serm and tesa as far as antibodies, according to Gemini. But no such studies. Anecdotally though, ipa w/ CJC is the most concerning of these.

With "human" in the name, HGH is the least likely to cause a systemic, immune reaction. In one study, only about 2 percent of children develop antibodies.

My single vial of ipa w/ CJC is still unopened. If I do use it, it will be really low doses to start. Maybe even 50 mcg haha. But now I am worried about tesa too, which I haven't started yet.

 

[RadicalCrimson]

At my age/IGF-1 score/Z score (57/181/0.7), +100 is probably a safe initial ceiling.

After taking >12mg reta + cagri, I've determined that visceral abdominal fat is probably my biggest issue now.

I scored very badly at this measurement test: https://www.lih.lu/en/visceral-fat-calculator/

Hence Tesa to the rescue.

 

[Gohengrin]

Are you fasting around your tesa use? My GH peptide use has motivated intermittent fasting (despite some natural hunger), especially if I split the dose into bedtime and AM.

Yes, dont eat from 7 pm and pin at 10pm.

 

[Gohengrin]

I saw this on a previous post with similar issues where there was a graph of weight over time and weight loss was progressing very steadily then went dead flat after hgh modifying drugs were added. So if there is a record or graph of what weight did over time it might help answer what is going on. If weight loss gradually slowed to zero, probably just less sensitive than average to the weight loss effects of reta/cagri , if there was consistent weight loss that suddenly stopped after tesa was started , that would be a bit of a giveaway as to the cause.

I have a weekly weight progression via shotsy. It stopped about 7 weeks ago, but Tesa was introduced about 5 weeks ago. Since then it goes up half a kilo and goes down half a kilo...natural fluctuaition.

 

[Calm Logic]

At my age/IGF-1 score/Z score (57/181/0.7), +100 is probably a safe initial ceiling.

After taking >12mg reta + cagri, I've determined that visceral abdominal fat is probably my biggest issue now.

I scored very badly at this measurement test: https://www.lih.lu/en/visceral-fat-calculator/

Hence Tesa to the rescue.

That calculator is certainly a wake up call for me too. It seems overly dramatic. But I guess it's the best free way most of us have to estimate, along with those cheap digital smart scales of questionable value.

Of course, lab results are much better for determining actual health effects:

Visceral Fat Status: Objective Metabolic & Physical Hierarchy ​

Rank Metric Clinical Accuracy for Visceral Fat 1 DEXA (VAT Scan) Direct: The ultimate way to see if your weight loss is coming from the "dangerous" internal stores or the "cosmetic" subcutaneous stores.

2 Fasting Insulin Causal: High insulin is the "on switch" for storing visceral fat. 3 ALT (Liver Enzyme) Organ Fat: Elevated ALT is a direct proxy for fat inside the liver. 4 ApoB / VLDL Lipid Export: VLDL is the "overflow" from a fatty liver; ApoB counts the total damage. 5 Blood Pressure Impact: High visceral fat triggers hormones that spike BP. 6 Trig/HDL Ratio Metabolic: Signals if the liver is "overflowing" fat into the blood. 7 Waist-to-Height Geometric: At 5'9", your target waist should be

 

[RadicalCrimson]

That calculator is certainly a wake up call for me too. It seems overly dramatic. But I guess it's the best free way most of us have to estimate, along with those cheap digital smart scales of questionable value

Today my Withings scale put me at a “healthy” lean mass score (78%) FOR THE FIRST TIME EVER, even though the scale hasn’t really moved for a week.

MAGIC!!!

 

[RadicalCrimson]

And water % is also up. I’m with you on the “questionable value”.

I did take my very first dose of Tesa 1mg+Ipa 100mcg last night, but I don’t believe in miracles.

 

[RadicalCrimson]

That calculator is certainly a wake up call for me too. It seems overly dramatic. But I guess it's the best free way most of us have to estimate, along with those cheap digital smart scales of questionable value.

Of course, lab results are much better for determining actual health effects:

7 Waist-to-Height Geometric: At 5'9", your target waist should be <34.5". 8 Thigh Circum. Protective: Larger, muscular thighs act as a "metabolic sink."

These are the same measurements the Luxembourg calculator asks as input.

WTH does the AI mean by “metabolic sink”?

 

[RadicalCrimson]

Looks like I’m going for only Tesa+Ipa, no CJC, no off days, titrating up to 2000/250, until my waist measurement goes down.

I am wearing a CGM now, this is fun.