Regular BAC vs BAC + Acetic Acid? Which is better for what?

[Mustafa]

I saw that QSC has two BAC water options, a regular one at 7.22 PH and another BAC + Acetic Acid option at 3.3 PH. Which is better for what?

I heard that cagri does better when acidic. Does that mean I should reconstitute my sema with BAC and my cagri with BAC + Acetic Acid?

 

[MrsRoper_1977]

It all depends on the peptide you’re reconstituting. Sodium bicarbonate is used for peptides too acidic, such as non-buffered Nad+, while acetic acid is used for peptides that need a lower pH (such as the much debated Cagri).

 

[49metal]

Just so you know: I wanted to target a lower pH for reconstituted cagri, so I used Hospira Bacteriostatic 0.9% Sodium Chloride. Specifically, the monograph of " Hospira Bacteriostatic 0.9% Sodium Chloride " reads "Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. May contain hydrochloric acid for pH adjustment . . . . The pH is 5.0. " When I reconstituted cagri with the latter, I got a solution with a pH of about 5.0 to 5.25. I tested the refrigerated solution's pH over the course for a few weeks and it was consistent. If I were going back to cagri I would try to use acetic acid to lower this to 4.0.

NOTE: I have no expertise in this and this approach may be ill-considered. But your question seemed to implicate my experience, so, FWIW, there you go.

 

[Lullabytreehugger]

You should use the AA (acetic acid) Bac water for cagri. Cagri likes a pH of around 3.5-4 max. But! At such levels the liquid is very acidic and will sting … so I dont know what needs to be done about that part …

Also make sure you filter your cagri to remove any fibrils formation following your reconstitution.

 

[49metal]

You should use the AA (acetic acid) Bac water for cagri. Cagri likes a pH of around 3.5-4 max. But! At such levels the liquid is very acidic and will sting … so I dont know what needs to be done about that part …

I do have AA vials for the purpose of further lowering pH. However, I'll admit to putting Cagri on hold while I process the oligomer FUD.