MOTs vs NAD???

[Loveandpeaceandjoy]

Okay so I did a 90 day cycle of NAD and energy was great and lost about 30lbs stacking with Tirz at 10mg weekly (microdosed). Wanted to try MOTs after reading about how great it is and just finished week 2 at 5mg M,W,F. Haven’t lost a pound, but didn’t gain, energy level improving, but it was rough the first week. Trying to decide if I should stay on this train with MOTs or get off. I still need to lose about 90 lbs. YouTuber that stacking MOTs and NAD can cause cellular overload and increase cancer risk. Need some feedback on your experiences or research on both. I don’t want to give up on MOTs too soon. Thanks folks!!!

 

[Calm Logic]

YouTuber that stacking MOTs and NAD can cause cellular overload and increase cancer risk.

Sounds like another paranoid or attention-seeking YouTuber. There may be a grain of truth to it, if one already has cancerous cells or genetic cancer risks:

NAD and Cancer: What We Know and What We Don't

Explore the link between NAD and cancer. What role does nicotinamide adenine dinucleotide play in cancer metabolism and what remains unknown?

www.jinfiniti.com

The statement "stacking MOTs and NAD can cause cellular overload and increase cancer risk" is a complex claim that requires a nuanced evaluation. Here's a breakdown of the current scientific understanding:

NAD+ and Cancer

* NAD+ is crucial for cellular function: Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme involved in many essential cellular processes, including metabolism, DNA repair, and gene expression.

* Cancer cells are "addicted" to NAD+: Tumor cells have high energy demands and rely heavily on NAD+ for their rapid growth and proliferation. Some cancer cells even upregulate the enzymes that produce NAD+ to support their metabolic needs.

* The "NAD paradox": This is where the complexity lies. Because cancer cells depend on NAD+, some cancer therapies are designed to inhibit NAD+ production to starve the tumors and induce cell death. However, NAD+ is also essential for a healthy immune system, which is crucial for fighting off cancer. Some research suggests that maintaining healthy NAD+ levels could actually support the body's natural anti-cancer defenses.

* Caution with supplementation: The relationship between NAD+ supplementation and cancer is not fully understood. Some studies have shown that high levels of NAD+ can make some cancers more potent and resistant to therapy. Therefore, many experts advise caution for individuals with active cancer or a high risk of cancer, as NAD+ supplementation could potentially fuel existing cancer cells.

MOTS-c and Cancer

* MOTS-c is a mitochondrial peptide: MOTS-c is a mitochondrial-derived peptide that plays a role in metabolic regulation and stress response.

* Potential for anti-cancer effects: Some studies suggest that MOTS-c might have a therapeutic role in cancer by interfering with a tumor's energy metabolism.

* Conflicting evidence: Other studies have raised contradictory claims, suggesting that MOTS-c could be linked to the development of certain cancers, such as prostate and breast cancer. Because of this conflicting information, caution is advised, and people with an active cancer diagnosis are often told to avoid MOTS-c unless directed by their doctor.

The "Stacking" and "Cellular Overload" Claim

* Limited research on stacking: There is very little, if any, specific research on the effects of "stacking" or combining MOTS-c and NAD+ supplements. The concept of "cellular overload" from this combination is not a well-established scientific term in this context.

* Potential for metabolic disruption: Both MOTS-c and NAD+ are deeply involved in cellular metabolism. MOTS-c can increase NAD+ levels and activate pathways like AMPK, which are central to metabolic control. It is plausible that introducing high levels of both substances could cause a significant disruption in cellular homeostasis, but the exact consequences are not known.

Conclusion

While there is no definitive scientific consensus on whether "stacking MOTs and NAD" directly causes "cellular overload" and increases cancer risk, the underlying premise is based on valid concerns about both substances.

* NAD+ and MOTS-c are powerful metabolic regulators.

* NAD+ is a double-edged sword when it comes to cancer. It is essential for healthy cells and the immune system, but cancer cells also exploit it for their growth.

* Research on MOTS-c and cancer is still in its early stages and has yielded conflicting results.

Therefore, the claim that stacking these substances can increase cancer risk is a plausible concern, particularly for those with existing cancers or a high genetic risk. The most responsible approach is to consult with a healthcare professional before taking any new supplements, especially those that have a significant impact on cellular metabolism.

The only reason I don't go to 15 mg of tirz is I don't like having diarrhea at Sam's Club, haha. So I will be stacking with survo in a few days, after finally buying a vial.

 

[ghreid]

just asked the new chat5 about MOTS cycle. response:

Got it — here’s a day-by-day SS-31 → MOTS-c mitochondrial optimization calendar using the “repair → overlap → adapt” approach.

Again, this is educational only , not medical advice.

​
Phase 1 – Priming (SS-31 only)

Days 1–7

SS-31 : 0.5–1 mg/kg SC injection once daily, morning (~8–10 AM).

Workout : Low–moderate intensity cardio or mobility work. Avoid high-intensity intervals.

Supplements:
CoQ10 (100–200 mg/day)

Magnesium glycinate (300–400 mg)

Creatine monohydrate (3–5 g)

Adequate protein (1.6–2.2 g/kg/day)

Goal: Reduce oxidative damage, restore mitochondrial membrane potential, improve ATP output.

​
Phase 2 – Overlap (SS-31 + MOTS-c)

Days 8–12

SS-31 : Same dose/time as Phase 1.

MOTS-c : 10–15 mg SC injection 2–3×/week , 1–2 hrs before exercise.
Example: Days 8, 10, 12.

Workout : Moderate–high intensity exercise on MOTS-c days (resistance training, interval cardio).

Supplements: Continue Phase 1 stack.

Goal: Let MOTS-c start metabolic reprogramming while SS-31 still protects the “hardware.”

​
Phase 3 – Adaptation (MOTS-c only)

Days 13–42

MOTS-c : 10–15 mg SC injection, 2–3×/week (e.g., Mon, Wed, Fri).

Workout:
MOTS-c days → high-intensity or long endurance sessions.

Non-MOTS-c days → recovery work, stretching, light cardio.

Supplements: Continue Phase 1 stack; consider adding nicotinamide riboside (250–300 mg/day) or NMN to support NAD⁺.

Goal: Drive mitochondrial biogenesis, metabolic flexibility, endurance gains.

​
Example 6-Week Calendar

Day

SS-31

MOTS-c

Exercise Type

1–7

✓ daily

—

Low–moderate cardio

8

✓

✓

Strength + intervals

9

✓

—

Light recovery cardio

10

✓

✓

Strength + endurance

11

✓

—

Recovery work

12

✓

✓

Strength + intervals

13–42

—

✓ (2–3×/week)

High-intensity on injection days, recovery otherwise

​
Tips for best results:

Hydration & electrolytes → Mitochondria are sensitive to ion balance.

Mild calorie surplus during SS-31 phase helps repair; slight deficit during MOTS-c phase can accelerate fat oxidation.

Sleep is non-negotiable — mitochondrial repair happens mostly during deep sleep.

 

[Desieldogg]

I'm currently at 220lbs (100 kgs), so chat5 recommends 50 - 100mg per day of SS-31???

 

[ghreid]

I wouldn't really trust Chat GPT for any dosing recommendations in humans. It recently recommended a patient switch from sodium choride to sodium bromide to decrease salt intake. Patient ended up in hospital with bromide toxicity. I'm doing 4mg (218lbs) SS31 daily run up and adding MOTs-c 5mg 2-3x/wk

 

[Sunflower]

Okay so I did a 90 day cycle of NAD and energy was great and lost about 30lbs stacking with Tirz at 10mg weekly (microdosed). Wanted to try MOTs after reading about how great it is and just finished week 2 at 5mg M,W,F. Haven’t lost a pound, but didn’t gain, energy level improving, but it was rough the first week. Trying to decide if I should stay on this train with MOTs or get off. I still need to lose about 90 lbs. YouTuber that stacking MOTs and NAD can cause cellular overload and increase cancer risk. Need some feedback on your experiences or research on both. I don’t want to give up on MOTs too soon. Thanks folks!!!

MOTSC only made me feel energized on the first dose, but I continued the cycle as recommended. NAD I use occasionally (not an official cycle) but don’t feel any difference.

Anecdotally, some people do better starting with SS31, so that is my next choice for mitochondrial peptide cycling.