每周服用 20 毫克雷他定的经验？

[BNLFL]

I assume there's a ignore feature here?

 

[Derby]

As I approach normal BMI, my loss rate has slowed from .24lb/day to .18lb/day over the past 4 months.

Lots and lots of words in this thread, but here's the main point for the OP: whether you are using a GLP-1RA or not, your weight loss will slow down as you approach ideal body weight. That is normal, not a failure of you or the drug. You should be thrilled losing > 1lb/week this close to goal.

 

[Calm Logic]

@hypnosisguy seems well aware of the research, far more than most, as evidenced by his previous threads so far. Not to mention 20 years of N=1 experience with weight loss:

[archived internal link]

Even at a BMI of only 26, it is still arguably safe to lose 2 pounds a week, if using strategies to maintain muscle, which is why I liked @tubby mentioning tesa and I playfully mentioned testosterone. But the more common/safer strategies are obviously protein, resistance training, and creatine supplementation. And I don't mind being in a stall for skin or muscle to catch up, or that's what I tell myself anyway.

But @hypnosisguy is already aware of muscle loss as a potential issue with any weight loss:

When will we get grey eloralintide

But reta + cagri still better? Prolly gonna be one of those fun constant comparisons that depend which team your on. I have 6 years of T. So for me, it's the T stack FTW

glp1forum.com

What I have learned the most is that focusing on bloodwork and body composition can be a relief if you still don't like what is on the scale. If your doc won't run some labs again anytime soon, people like GoodLabs and Fitomics for lipids, A1C, etc, in addition to IGF-1 and testosterone for shits and giggles, though it seems most docs will order testosterone if you ask.

 

[randompersonrandom]

I assume there's a ignore feature here?

Yes! Click the person's name in any thread and it's right there. It doesn't even stop you from being able to read drama threads, because you'll see other people responding to them, though it'll cut their text unless you click "show ignored content."

 

[BNLFL]

Yes! Click the person's name in any thread and it's right there. It doesn't even stop you from being able to read drama threads, because you'll see other people responding to them, though it'll cut their text unless you click "show ignored content."

Thanks. Yeah, we have it in another forum I'm an admin on. I just never looked here. It wasn't for me, someone else.

 

[hypnosisguy]

I was interested in the 20mg/wk number because I saw that number mentioned in another thread, and I'd like the data on any symptoms/results. The 12mg limit comes out of phase 2 studies showed diminishing returns for the general population at 12mg, but there are likely individual exceptions. Since it sounds like there are people with personal data, I'd like to hear from them.

I do expect that I will go (somewhat) higher than 12mg if my weight loss slows and I find myself responsive to the higher dose.

they have done a great job so far but are still in the mindset of seeing a certain number loss every week rather than a bodyfat percent change

In fact, I measure my bodyfat percentage (by proxy) daily with a waist measurement. My waist shows linear decrease of 0.03 in/day, which is about equivalent to 0.04 %/day, using the Navy equation. I have had dexa scans periodically that confirm the gross accuracy of the method.

However, I have been very muscular at high body weights (I could do pull-ups at a 270lb body weight), and I am skeptical of the simplistic theory that "muscle=good, fat=bad." For a lot of later life health issues, I suspect that your body systems (heart, kidneys, liver, circulatory system, etc.) only have so much carrying capacity for total tissue mass. This is why short people live longer. Lean or fat, it's bad to be big.

 

[tubby]

The 12mg limit comes out of phase 2 studies showed diminishing returns for the general population at 12mg, but there are likely individual exceptions. Since it sounds like there are people with personal data, I'd like to hear from them.

That's an insightful point that you bring up there, but there are a couple wrinkles to the phase 2 trial that I think are worth exploring.

First, the trial wasn't long enough to establish plateau levels for 8 or 12 mg doses. Had the trial went on longer, it's entirely possible the averages for the 8 and 12 groups would have diverged further before plateauing. When you compare the 8mg (ID 2mg) group to the 12mg (ID 2mg group), which is a proper apples to apples comparison, those lines do diverge. It's only when we overlay the 8mg (ID 4mg) group with the 12mg (ID 2mg) group that the lines blur and I wouldn't be surprised if that has more do to more rapid dosing escalation early on than final dosing.



其次，该图表显示的是平均结果，但个体参与者的结果差异很大。有一点尚未研究（我认为非常值得研究），那就是同一患者在不同剂量水平下的反应差异。正如有些人每周服用1毫克就能产生超敏反应（对他们来说，这最终会成为高治疗剂量）一样，一些原本无反应的人也可能突然变成正常反应者（就像服用更高剂量一样）。平均结果确实暗示了这种情况的可能性。



对于某个人来说，如果以体重减轻总量（达到平台期）为纵坐标，以 reta 剂量为横坐标绘制图表，图表很可能看起来像这样，其中 X 轴的刻度因人而异。