That's the main issue that I"ve had with GLP's. THey are supposed to help suppress appetite. I was on Tirz for 5 months and up to 12.5. THe day after the first shot at 2.5 , I woke up and and had no appetite. That lasted for 4 days and then NOTHING for the next 5 months. I have been on Reta since last July and was up to 10mg/week in mid-Dec. I was waiting for more stock and was trying to ration what I had so I stayed at 10mg for 2 months and then all of a sudden, I start to get suppression. When my shipment came in I thought about going up more but stayed at 10 up until now and I'm starting to lose that suppression and will have to increase. At some point I"m afraid that it just won't work and I have alot of weight to lose and haven't made much progress. . Since the weather warmed up I have been walking more but that has a tendency to increase my appetite.