Is anyone doing a Reta + Tirz?

[lessthanhalf]

Thanks less than half. You hit the nail on the head about specifics. I did find some results on GLP-1's. Shoot, my wife's doctor suspend her Ozempic 2 weeks prior and 2 weeks after her surgery but that was for a gall bladder and she takes it for diabetes. I suffered a compound fracture in my right leg just above the ankle. Tibia shattered and pooped 4 inches out of me leg, fibula snapped and I sheared my tibial nerve. I was 6'7" and 275lbs and lived in the gym 5-6 days a week and swam, stair climbed often. This happened in June 2025 and was non weight bearing for 16 weeks. Im now 340 lbs and had another surgery yesterday to install a larger bolt in my leg and bone graft for a non-union and non-weight bearing again for 8-12 weeks. But, I do have access to scholary articles through a university that you suggested. Im motivated to get in there and find out so I can get in there and get this weight off but not stop the healing process. I appreciate you! Attached photos from first surgery...when I do things, I do them big!

I just had another quick look at some of the studies, and there are a lot and they are still pretty contradictory. There is one study showing higher rates of non union after surgery to fix lower leg fractures in people taking GLP's, a surprisingly good fit for your problem, so I guess that is good enough to justify not taking them around and after the fracture until it has started healing up. But several large studies show significantly reduced rates of complications and later readmissions after elective surgeries like knee replacements, and especially hernia repairs. And there are many studies showing better outcomes in diabetics on GLP's for many different surgeries. And people are less likely to get addicted to painkillers after bariatric surgery and probably every other type of surgery if on GLP's.

It definitely sounds like the sort of thing you would need to listen to the surgeon's opinion on, even if they are not up with the latest research it is generally better not to annoy your surgeon.

The fracture sounds totally gruesome with the bone sticking out 4 inches!. Definitely a thank god for modern medicine problem to have, even if it is taking a while to get sorted out.

 

[woundcarping]

Was on Tirz 15mg, now on reta 1mg every three days. Want to add Tirz back in, because so far, no positive or negative effects on Reta alone, except eating a whole bag of chips in the days between pins.

You went from 15mg of Tirz to ~2mg of Reta…. Have you considered upping your Reta dose? It makes no sense going from a “max” dose to less than a “starting” dose and having any expectations of efficacy.

 

[lessthanhalf]

In response to the above post and attcbf

You should be able to go straight to at least 5 or 6 mg of reta from 15mg of tirz, and that is being very careful. There are no guidelines anywhere for swapping from tirz to reta but 15mg of tirz is probably about equivalent to 8 to 10mg of reta in terms of gastrointestinal side effects, which is the most common issue.

If you have already lost a decent amount of weight you are going to be super hungry after stopping 15mg of tirz and going to a tiny dose of reta.

Assuming you do not have heart disease or diabetes you should be able to just use 6mg of reta and see if you get side effects, you would have to be very unlucky to get worse side effects than you got from 15mg of tirz, but it is not impossible.

If you are patient then doing it very slowly and carefully is the safest way and the way to get least side effects, but if you are worried about binging and putting on 10kg in a few weeks, then go straight to 6mg , if no side effects add an extra 2mg after 2 or 3 days , if still no side effects, do that again and you are up to 10mg in a week with fairly low risk of unexpected and prolonged side effects. You might need to stay on twice a week doses and give your body time once you get to 10mg but if you are ok with that dose you can gradually shift it back to once a week. I am only suggesting this option as you already tolerated 15mg of tirz ok. Doing this if you have never taken GLP's before could be extremely unpleasant. And this assumes you did not have lots of side effects on 15mg of tirz.

The weekly dose is just the sum of the doses over a week, just make sure that adds up to less than 10 or 12mg.

If you want to be more careful just go to 6mg and bump it up to 8mg after 2-4 weeks, and the same after that, till you get to 12mg , it really just depends on side effects, if you have none , then small dose increases are very unlikely to be a problem.

The only side effects that are more likely with reta than tirz are increased heart rate and skin sensory symptoms

 

[woundcarping]

You can also frequently (ie daily) dose smaller increments as you work up so if there’s adverse sides you don’t have to wait as long for the overage to clear. I took 7mg my first week going that route. That was two months ago, taking 8-10mg/week now, split dosing, no adverse sides along the way.

 

[attcbf]

If you have already lost a decent amount of weight you are going to be super hungry after stopping 15mg of tirz and going to a tiny dose of reta.

Thank you lessthanhalf for the very thoughtful response. I lost 80 lbs with Tirz (zepbound) in about a year. Absolutely no side effects on the Tirz. But my insurance decided that I was now good to go, BMI under 30, and denied my doctor's reauthorization request (the evils of insurance companies is for another day). Spouse started micro-dosing Reta, and I thought with the little that we have, I should at least try it until our order comes in. [That was probably TMI, but figure I am a newbie and providing a better intro is not a bad idea.]

I ordered both Reta and Tirz and am not sure if I should do each, every other day, or just stick with a larger dose of Reta. Your post and woundcarping's have given me much to think about.

 

[attcbf]

You went from 15mg of Tirz to ~2mg of Reta…. Have you considered upping your Reta dose? It makes no sense going from a “max” dose to less than a “starting” dose and having any expectations of efficacy.

actually closer to 3mg/wk over a 2 week span (side rant, it would a whole lot easier to calculate dosing if the number of days in a week wasn't a prime number). But I understand your point. And, so far have only seen an increase in carb eating at that dose. Unfortunately, I am waiting for an order to be delivered, so cannot increase at the moment.

 

[JuneBug1956]

How long do you think you'll be off for surgery? I've been searching this topic as there isn't any real solid conversations on it and my surgeon said he would love to prescribe me monjourno but he won't because there isnt data on how this will effect soft tissue/bone growth. Any insight is appreciated!

If you are on Peppy’s or Discord you could ask this question on Roundtable. I think it probably hasn’t been studied very well but the big concern might be loss of appetite, weight loss ( your goal) and poorer nutrition. That can affect bone healing. Possibly if you worked along side a nutritionist might mitigate the nutritional loss. I suspect it hasn’t been robustly studied on healing fractures.