I'm not impressed.

[Olbartmore77]

There are no official dose equivalents for the GLP's.

The answer depends a bit on what side effects you got from tirzepatide either at your current dose or as you increased doses. Obviously the more side effects the lower swapover dose. If you have cardiovascular disease maybe go lower as well due to the heart rate increase being larger on reta. And it depends on general health and other illnesses, especially diabetes.

In terms of straight equivalents it is probably about 8-10mg. Reta has higher glp-1 agonism and less gip agonism so can cause more gi side effects than tirz.

To be safeish I would go with 6-8mg, but there is always a chance of more side effects than expected from different GLP's, so if being a bit pukey for a week might interfere with work or something else go lower rather than higher.

I was very fortunate to have zero side effects throughout the course titration with Reta. I’m sure my luck has to run out and when I start Reta I’ll be sure to keep your advice in mind. Thank you for the reply.

 

[Bakerskibum87]

I think you can do 4.5mg a week on cagri

I do 2.5 Cagri and 6 mg Reta and can’t think about eating

 

[JustMakeItHappen]

Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.

Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.

Week 2- .5 mg with 15mg tirz. Still nothing really of note.

Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.

Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.

Week 5- 1mg with 15 tirz, not even a grumble.

Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?

Do you know of any cheat codes i dont?

What could be unique with me that im not responding as well as so many others?

Similar to you, i became 'used' to Reta.

Given that, ive been on it over 12 months and im still only on 4mg/week

But the last 4 weeks ive actually incorporated 1 mg of Cag and its fantastic.

That mix has me feeling satiety for 6-7 days MOST weeks. (depending on how ocupied i am)

Can we get an update though? I went through and noticed you havent replied to anyone.

Im curious

 

[onewalker]

If I can weigh in, I’ve just incorporated 1 mg/week of Cagrilintide and it’s working really well. Currently on 4 mg/week Retatrutide as well. Great appetite suppression for me and I’ve dropped two pounds the last week.

Also saw one inch less around the waist (maybe more) which seems insane to me for just one week. Fat around the waist/internal organs is also the main thing I’m targeting right now more than general weight loss.

 

[days_before]

I am currently on 1.6 mg of reta every three days. I tried 0.2 mg of cagri and it apsolutely destroyed my apetite. Still managed to eat 200g of protein but it was very difficult. I think il pause the cagri for now and up my reta. Maybe introduce cagri again when my reta dose is higher

 

[RetCurious]

to most people who hear "the science."

So you're polling most people?

 

[tubby]

So you're polling most people?

I wasn't able to get ahold of Most, so I spoke to his sister Some and Some told me that Most felt that way.

 

[deluge]

But my username’s Retazempic. That has to count for something.

It absolutely does!

On the other hand, his avatar is a guy in a lab coat, so I think it balances out.

 

[Bakerskibum87]

I am currently on 1.6 mg of reta every three days. I tried 0.2 mg of cagri and it apsolutely destroyed my apetite. Still managed to eat 200g of protein but it was very difficult. I think il pause the cagri for now and up my reta. Maybe introduce cagri again when my reta dose is higher

With a 6 day half life why in the world would you pin every 3 days?

 

[Retazempic]

With a 6 day half life why in the world would you pin every 3 days?

Might help manage side effects

 

[days_before]

With a 6 day half life why in the world would you pin every 3 days?

Lowers the risks of side effects by a ton. A lot of people do it like that maybe even more than the ppl that do it once per week

 

[trojanpeptide]

I pin 2mg on Mon and Thur. I lose the big peak but it's a smoother ride.