GLP-1 Receptor Agonist Exposure During Pregnancy:

[RetCurious]

A Systematic Review and Meta-Analysis of Adverse Pregnancy Outcomes

What is the clinical question being addressed?

What are the effects of GLP-1 RA exposure during pregnancy on maternal or fetal outcomes, compared to other antidiabetic therapies?

What is the main finding?

GLP-1 RA exposure was associated with improved maternal and preterm birth outcomes, with no significant increase in congenital malformations or overall adverse fetal outcomes.

https://www.jacc.org/doi/10.1016/j.jacadv.2026.102649

 

[lessthanhalf]

The short answer is stop them a few months before getting pregnant, as with most medications if possible, as their safety is not yet known. This is the start of working out if they are safe or not but likely will not be established for a long time as no ethics committee is going to approve a trial, so it will be the results of many unintentional exposures over years that produces answers. There are no alarming signals so far, and results like this suggest early pregnancy exposure is not likely to be an issue, but definitely something that would require expert advice if you were to get pregnant while taking them, and no one is going to recommend staying on them if pregnant until there is much better data. Given the number of ozempic babies, early pregnancy safety is likely to be worked out much sooner.

 

[Calm Logic]

I was surprised to read that even BAC water is banned from neonatal units.

Regarding pregnancy:

Bacteriostatic Water Injection

Choose Empower Pharmacy for compounded Bacteriostatic Water Injection. The leading accredited 503A and FDA-registered 503B compounding pharmacy.

www.empowerpharmacy.com

In practice, using bacteriostatic water as a diluent for a single-dose medication in a nursing mother is unlikely to pose significant risk, but caution is still advised. If repeated injections (containing bacteriostatic water) are required in a breastfeeding mother, healthcare providers will consider the potential accumulation of benzyl alcohol.

As with pregnancy, an alternative preservative-free diluent may be preferred for nursing mothers if feasible.

Ultimately, decisions on using bacteriostatic water during pregnancy or lactation should involve a risk-benefit assessment by the physician, and therapy should be monitored closely.

 

[CrimsonTaco47]

The short answer is stop them a few months before getting pregnant, as with most medications if possible, as their safety is not yet known. This is the start of working out if they are safe or not but likely will not be established for a long time as no ethics committee is going to approve a trial, so it will be the results of many unintentional exposures over years that produces answers. There are no alarming signals so far, and results like this suggest early pregnancy exposure is not likely to be an issue, but definitely something that would require expert advice if you were to get pregnant while taking them, and no one is going to recommend staying on them if pregnant until there is much better data. Given the number of ozempic babies, early pregnancy safety is likely to be worked out much sooner.

I was actually contacted right after getting pregnant for a study. They were doing on Ozempic during pregnancy. I had previously been on mounjaro for 10 months before pregnancy. Got outfit to get pregnant, assuming it would take some time and got pregnant with it in a few weeks of stopping so they are definitely are studies out there. Considering women with diabetes still have to take their diabetes medication during pregnancy. It’s a pretty logical step that they’re testing for this too. This would have been like August or September 2023 ish when I was contacted

 

[myopicmystic]

I believe EL has a site to report exposures during pregnancy, so I'm sure there will be observational data eventually.